<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26098

Description Cyclin dependent kinase 8
SequenceMGDNFQNKTMAAVMMDYDFKIKTQNERSKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKSVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIRKMPEHATLVKDFKRSNYQNCSLSKYMDRHKIKPDSKAFSLLQRLLLMDPNKRITSEQAMQDPYFAEDPLPTQDVFAGCTIPYPKREFLTDDDQEDKSDSKARQNQQQQQPNTQQNQVQQNSHDHGANNAKRMRMTGPNQGNNTGGGQQEFHQQQQMMFGSQQQGGSSQQQGNYQQRF
Length462
PositionKinase
OrganismBombyx mori (Silk moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Bombycoidea> Bombycidae> Bombycinae> Bombyx.
Aromaticity0.09
Grand average of hydropathy-0.745
Instability index42.87
Isoelectric point8.77
Molecular weight53470.14
Publications
PubMed=19121390

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26098
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.29|      25|      39|     115|     152|       1
---------------------------------------------------------------------------
  116-  143 (41.75/39.24)	HDLWhiiKFHRAAKANKKSVM..VP.KGMVK
  157-  184 (38.55/11.30)	HSNW...VLHRDLKPANILVMgeGPeRGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.63|      44|      45|     369|     412|       2
---------------------------------------------------------------------------
  312-  351 (47.55/25.72)	.......DRHKIKPDSKAFSLLQRlllMD..........PNKRITSEQAMQDPYFAE
  369-  412 (76.88/46.11)	KREFLTDDDQEDKSDSKARQNQQQ...QQ..........PNTQQNQVQQNSHDHGAN
  415-  460 (47.19/25.47)	KRMRMTGPNQGNNTGGGQQEFHQQ...QQmmfgsqqqggSSQQQGNYQQ........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26098 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTDDDQEDKSDSKARQNQQQQQPNTQQNQVQQNSHDHGANNAKRMRMTGPNQGNNTGGGQQEFHQQQQMMFGSQQQGGSSQQQGNYQQRF
365
462










Molecular Recognition Features






MoRF SequenceStartStop




1) GGGQQEFHQQQQMMFGSQQQG
2) KRMRMTGP
3) SSQQQGNYQQRF
429
415
451
449
422
462