<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26091
Description |
Mediator of RNA polymerase II transcription subunit 4 (Fragment) |
Sequence | MAASLSGEKEKERSGGGSGAAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLPPDEENQVLELLIHRDGGFQERMKLARNRGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 270 |
Position | Middle |
Organism | Ailuropoda melanoleuca (Giant panda) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.729 |
Instability index | 49.59 |
Isoelectric point | 5.22 |
Molecular weight | 29785.04 |
Publications | PubMed=20010809
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP26091
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.50| 24| 29| 25| 53| 1
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29- 53 (33.50/30.38) RLLSALEDLEVLSrELI.......EMLAISRN
55- 85 (34.00/16.02) KLLPPDEENQVLE.LLIhrdggfqERMKLARN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.92| 22| 23| 94| 115| 2
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94- 115 (33.52/24.54) QVLEKEVEKRDSDIQQLQKQLK
119- 140 (32.40/23.50) QILATAVYQAKEKLKSIEKARK
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