Description | Mediator of RNA polymerase II transcription subunit 21-like Protein |
Sequence | MADRLTQLQDCINQQAEHFCNSIGILQQFAPPSKFPNFDRSGSQTPQQQNQEDYVQLFTTLIARCAKDIDTLIESLPSEENSTELQLQSLRILESDNQESAERLEAIVRKGQDLLEQIQAALSDIAQSQLDMQHLTKAGSKDS |
Length | 143 |
Position | Middle |
Organism | Tribolium castaneum (Red flour beetle) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.617 |
Instability index | 63.11 |
Isoelectric point | 4.42 |
Molecular weight | 16078.64 |
Publications | PubMed=18362917 PubMed=19820115 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP26086 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) AERLEAIVR 2) NSTELQLQSLRILESDN 3) QNQEDYVQLFTTLIARCAKDIDTLIESLP | 101 81 49 | 109 97 77 |
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