<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26065

Description Cyclin-dependent kinase 8
SequenceMDYEFKMKTQQERAKVEDLFEYEGCKVGRGTYGHVYKAHRKESNDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKATKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIRKMPEHHTLTKDFKRSNYANCSLVKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGESKRQQQQQQQQQANQQAQQNQQQQANHQNQQQNQQQQANQQNQQSQQQQQQQQMQQQQQAQAGGMDHSAAKRVRMSGPNGQPGNGMNQQDYQVQQAQQAAAAAAAAQQQQQQQQQQQMMFNNQQQGGFQQRY
Length501
PositionKinase
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.08
Grand average of hydropathy-0.930
Instability index52.69
Isoelectric point8.65
Molecular weight58256.03
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). 
ECO:0000250	UniProtKB:Q9VT57
GO - Cellular Component
nucleus	GO:0005634	ISS:UniProtKB
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:UniProtKB-EC
protein serine kinase activity	GO:0106310	IEA:RHEA
protein threonine kinase activity	GO:0106311	IEA:RHEA
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:UniProtKB-EC
GO - Biological Process
G1/S transition of mitotic cell cycle	GO:0000082	ISS:UniProtKB
protein phosphorylation	GO:0006468	ISS:UniProtKB

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26065
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.39|      27|     102|     373|     399|       1
---------------------------------------------------------------------------
  373-  393 (37.99/ 9.51)	.......QQQQQQQQQA.NQQAQQNQQQQ
  394-  418 (50.65/14.66)	ANHQNQ...QQNQQQQA.NQQNQQSQQQQ
  452-  477 (31.61/ 6.92)	GNGMNQqDYQVQQAQQA.AAAAAAAQQ..
  478-  500 (32.14/ 7.13)	.....Q.QQQQQQQQMMfNNQQQGGFQQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.94|      16|      26|     239|     263|       3
---------------------------------------------------------------------------
  239-  256 (22.79/30.19)	EDIKtSNPYHHdQLDRIF
  268-  283 (31.16/11.44)	EDIR.KMPEHH.TLTKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.00|      12|      18|     333|     344|       5
---------------------------------------------------------------------------
  333-  344 (23.63/15.93)	PYFSEDPMPTAD
  352-  363 (22.37/14.71)	PYPKREFLTDED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26065 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGESKRQQQQQQQQQANQQAQQNQQQQANHQNQQQNQQQQANQQNQQSQQQQQQQQMQQQQQAQAGGMDHSAAKRVRMSGPNGQPGNGMNQQDYQVQQAQQAAAAAAAAQQQQQQQQQQQMMFNNQQQGGFQQRY
320
501










Molecular Recognition Features






MoRF SequenceStartStop




1) GMDHSAAKRVRMSG
433
446