<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26063

Description Isoform 2 of Cyclin-dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Length442
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.09
Grand average of hydropathy-0.707
Instability index53.87
Isoelectric point8.66
Molecular weight56801.55
Publications
PubMed=14574404
PubMed=15489334
PubMed=10470851
PubMed=12168954
PubMed=18691976
PubMed=19369195
PubMed=22814378
PubMed=32330417
PubMed=33134521
PubMed=33495529

Function

Annotated function 
GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
protein serine kinase activity	GO:0106310	IEA:RHEA
protein threonine kinase activity	GO:0106311	IEA:RHEA
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
cellular response to lipopolysaccharide	GO:0071222	IEA:Ensembl
positive regulation of apoptotic process	GO:0043065	IEA:Ensembl
positive regulation of inflammatory response	GO:0050729	IEA:Ensembl
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.50|      39|      41|     319|     357|       1
---------------------------------------------------------------------------
  319-  357 (70.65/37.96)	DPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKRE
  363-  401 (72.85/39.36)	DPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.46|       9|      37|     424|     460|       2
---------------------------------------------------------------------------
  410-  418 (17.89/25.23)	GGAGAGVGG
  443-  451 (18.58/10.86)	GPSGANSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     187|     226|       3
---------------------------------------------------------------------------
  151-  177 (31.61/19.09)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  180-  219 (59.27/52.78)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  220-  241 (28.35/15.00)	IGCIFAELLTSEPI...FHCRQEDI................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.46|      14|      15|     463|     476|       7
---------------------------------------------------------------------------
  463-  476 (26.41/17.53)	SRLNYQSSVQGSSQ
  479-  492 (26.04/17.18)	STLGYSSSSQQSSQ
---------------------------------------------------------------------------











Associated diseases
Disease
Cardiovascular diseases , cancer	PMID:24751643 PMID:24746821 PMID:33257171 PMID:24754906 PMID:29266937 PMID:32463833 PMID:32752128 PMID:28220308 PMID:29780169
breast cancer	PMID:31988137 PMID:24427329 PMID:32078847 PMID:26452386 PMID:31622095 PMID:28147342 PMID:31087707 PMID:33173974
colon cancer	PMID:31988137 PMID:28231524 PMID:21806996 PMID:20514474 PMID:19808961 PMID:26235356 PMID:22104393 PMID:33291686 PMID:29967145
prostate cancer	PMID:27678455 PMID:32078847
melanoma	PMID:22035865 PMID:32078847 PMID:23454913 PMID:26235356
colorectal cancers	PMID:22035865 PMID:30594029 PMID:22945643 PMID:28191946 PMID:27490956 PMID:23454913 PMID:18794900 PMID:21179167 PMID:19790197 PMID:32596239
endometrial cancer	PMID:31520353 PMID:23454913
uterine cancer	PMID:31520353
gastric cancer	PMID:28231524
lung cancer	PMID:32802198
acute myeloid leukemia	PMID:31382571
cancer  cardiovascular diseases  metabolic diseases	PMID:30352217
inflammatory disorders  viral infections  cancer	PMID:28855340
Gastric adenocarcinoma	PMID:21344156
pancreatic cancer	PMID:29856990 PMID:25305448
colon cancer hepatic metastasis	PMID:30185549
cardiovascular diseases	PMID:31255603 PMID:30352217
Congenital heart disease	PMID:30905399 PMID:24751643
inflammation diseases	PMID:33257171
metabolic diseases	PMID:30352217
periodontitis	PMID:32978798



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26063 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
353
502










Molecular Recognition Features






MoRF SequenceStartStop




1) LNYQS
2) NKKPRLG
3) QYHPSHQAHRY
465
437
492
469
443
502