<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26057

Description Cyclin-C
SequenceMAGNFWQSSHSQQWILDKPDLLRERQHDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSAIKTKFSYAYAQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLRTDVCLLYPPYQIAIACLQIACVILQKDATKQWFAELNVDLDKVQEIVRAIVNLYELWKDWKEKDEIQMLLSKIPKPKPPPQR
Length267
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.11
Grand average of hydropathy-0.088
Instability index49.31
Isoelectric point5.99
Molecular weight31292.06
Publications
PubMed=1836192
PubMed=1833067
PubMed=10731132
PubMed=12537572
PubMed=8730095
PubMed=17290221

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation. 
ECO:0000269	PubMed:17290221
ECO:0000269	PubMed:1833067
ECO:0000269	PubMed:1836192
ECO:0000269	PubMed:8730095
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IBA:GO_Central
GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IDA:FlyBase
transcription coregulator activity	GO:0003712	IMP:UniProtKB
GO - Biological Process
F:transcription coregulator activity	GO:0003712	IMUniProtKB
chaeta development	GO:0022416	IMFlyBase
imaginal disc-derived leg segmentation	GO:0036011	IMFlyBase
positive regulation of autophagy	GO:0010508	IGI:FlyBase
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IMUniProtKB
sex comb development	GO:0045498	IMFlyBase
snRNA 3'-end processing	GO:0034472	IDA:FlyBase

Interaction

Binary Interactions
[P25008<-->P23572: Cdk1]	NbExp=4	EBI-195485,EBI-108689
[P25008<-->P48609: Cdk5]	NbExp=4	EBI-195485,EBI-94216
[P25008<-->Q9VT57: Cdk8]	NbExp=2	EBI-195485,EBI-163640
[P25008<-->Q9VW47: kto]	NbExp=2	EBI-195485,EBI-139710
[P25008<-->Q7KTX8: skd]	NbExp=2	EBI-195485,EBI-110730

Repeat regions

Repeats

>MDP26057
No repeats found


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP26057 with CycC domain of Kingdom Metazoa



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) IQMLLSKIPK
251
260