<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26045

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSEKSDHSELGSPVWGATIEPVWLGERSRQPREKIDDAVWGSQELNELLKRDSHVSVPLDENLKHPDELEVIHKYYLTGMGYGPGTMFPSPLNHRPLNGTHSLGNICDEAKCVSEEIFREWKILRGRIHDKEHNAVLTNALAHLFEHSPLGARHLFFDKCWKKTQQYFLKCDPESTTPLPLARLARQDVANMIAEAKGVAIVGGYPYTEAGIELCAAIRGMRFKMRETNTIESLRYLNSMRLVYELFFDLLAPLLCQKNLNDPGMLAAFLVSRADDHPAAFARADFRQMYVGLANRWFSPFACFLGTEMSLDEPDLTTNSSGAEKEDWKLEATQLKEHTETYGRLFDFSAQYWRSNGHAEWAPIGAKYTRLKMTPVTGGNDTKRQEFLETAGEVERRLTKKLCNARSREAASKIESDKAGRTYSFLDGFAQSPGQLSWITEDLAQYRELQMRERCTGTDKPWADLGLHLGDPRGISSEQARYQPYTKPHRGSDSTGAKPLVIPSLEAQRLESIAMFQELMKNSSALKIMFKTELEHHHGWIRDKKDQILENLDKASNMPQAVVTEVTLDIIERVFRRRILDVELFHFVHEHYNRFTESPASLSASDWLFLQVHAREFASHYWHDLSRRGIWHAHPRWRQCFRRSTKFRSIANGLPQYLLPVGMETQDQQKWFVLNDDSANADEELKQLFSLTGHLMHRFVTQKEAASFVGLGNLLDTLTPLLPRLRQHEFISDYVFKTIENLNICVQMVKQLDLHRDGERELRPYLDSGPGQSSEPPRSALLKSLSTVIGEVFPRASHYTRHQALKSLSPLLHGKSPSDRDASRTIRGIWYAFVARIAGYDTKREDAVSLDDAPHTKLDPKNSQESLVGPGLMEHWGIIIQDRTDQLETLSSSPSSHKSTPPKPQTPPPRVELRTTTSPAHHPPGWVPGQNTNPRPRLPQEAAAPVIAEPPPVPAEPLPPLAPDTWRIFDNIFGGYENYSMSQLVQAFKAIGWRVEQSENGLNFLWSPECRLPAPVNSMAMQIHPYKHKKPTAKVQSEAWKSGNRNRFEERGVSQQSLQTHYNGCPGWHRPKYDLEPATQGIHRCEGTAECNNMEQPGYILPPLLTPEEQHKWIEELNTLLSLRLNLDDYDKIPQQFKNYTIKSGRVTFTVEGEF
Length1155
PositionTail
OrganismVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.09
Grand average of hydropathy-0.601
Instability index49.69
Isoelectric point6.61
Molecular weight131683.46
Publications
PubMed=21829347

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26045
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     347.25|      85|      88|     706|     791|       1
---------------------------------------------------------------------------
  635-  722 (118.53/64.58)	PRWRQC.FRRST.KFRSIANG..LPQYLLPVGMETQDQQKW.FVLNDDSANADEE.....LKQLFSLTGHlmhrfvtqkeaASFVGLGNLLDTLTPLL
  723-  812 (130.99/75.70)	PRLRQHEFISDY.VFKTIENLNICVQMVKQLDLHRDGERELRPYLDSGPGQSSEPPRSAlLKSLSTVIGE.......vfprASHYTRHQALKSLSPLL
  813-  880 (97.72/51.99)	....HGKSPSDRdASRTIR..GIWYAFVARIAGY.DTKREDAVSLDDAPHTKLDPKNSQ......................ESLVGPG.LMEHWGIII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.99|      10|      20|     104|     113|       3
---------------------------------------------------------------------------
  104-  113 (20.11/11.88)	GNICD.EAKCV
  126-  136 (14.89/ 7.09)	GRIHDkEHNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.17|      11|      23|     886|     897|       5
---------------------------------------------------------------------------
  886-  897 (15.42/13.77)	QLETlSSSPSSH
  912-  922 (20.75/13.15)	ELRT.TTSPAHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      21|      23|     405|     427|       6
---------------------------------------------------------------------------
  405-  427 (29.69/28.00)	ARSREAASKIESDKAgrTYSFLD
  430-  450 (37.81/27.27)	AQSPGQLSWITEDLA..QYRELQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.71|      43|     140|     924|     966|       7
---------------------------------------------------------------------------
  924-  966 (84.95/46.23)	PGW.VPGQNTNPRPRLPQEAAAPVIAEPPPVPAEPLPP.LAPD...TW
 1066- 1113 (70.76/37.16)	PGWhRPKYDLEPATQGIHRCEGTAECNNMEQPGYILPPlLTPEeqhKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.82|      12|      21|     212|     223|      16
---------------------------------------------------------------------------
  212-  223 (21.57/18.23)	IELCAAIRGMRF
  231-  242 (20.24/16.55)	IESLRYLNSMRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26045 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RTDQLETLSSSPSSHKSTPPKPQTPPPRVELRTTTSPAHHPPGWVPGQNTNPRPRLPQEAAAPVIAEPPPVPAEPLPPL
883
961










Molecular Recognition Features






MoRF SequenceStartStop




NANANA