<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26044

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDQSEIDFWVGLAQTEQQASVSLTLITVDTSPSLQLVPPAVKVPPTASTSFYTTPVSTPQPSTVSPDQIGTPSTPMKDGSQANASTPTGTPGGADVTEPAEGDAILVDVTDQTWGAVLSHRLGNSTAPGELSTSLISGYLVKRGGTKVEDPPVVMEVNIVHTDGNPRALEALLREMLNYFRGLGTLARARGIVDRETDVRPWHIAAAEKGVRALYLLM
Length218
PositionKinase
OrganismVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.05
Grand average of hydropathy-0.144
Instability index33.98
Isoelectric point4.72
Molecular weight23047.68
Publications
PubMed=21829347

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26044
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.48|      40|      50|      56|      99|       1
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   28-   55 (31.07/ 8.12)	VDT.SPSlQLVPPAVKVPPT....ASTSFYTTP..............
   57-   98 (58.78/30.56)	.STPQPS.TVSPDQIGTPSTPmkdGSQANASTPTG...TPGGADVTE
  109-  150 (54.63/20.36)	VTDQTWG.AVLSHRLGNSTAP....GELSTSLISGylvKRGGTKVED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26044 with Med13 domain of Kingdom Fungi
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