<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26041

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNPMETTTHDGDQVMNHDAISAGDIPMNGPMQVDGLDVDDLFGDGVNLTLPNVRGPSRQLAQRVDEMRTRGCAQGIAWSKSGTIAYISPDGRSVQVRYLRADPKTGGWGLSEPTTVDAITASPSTPIVHLAWAATSSNELAVIDAAGRVAILAFSVSLNRPFLTRKWDADHVDDLHAIAGCFWLPLASQHKNYHVFHGPAVKDATAYRYESSFIHAFGPWHPNPAKSALLCVTTSGMLRLFWSQSNNKLEETTLELDSFSSSDDLITHASLHSDKNHMYVALATASRQLRLVRPLNPTMTAKHLAISSWMPNGQSGNPIDASMTQISHIELLPSQLDNTGHNWVPMNVLVVRSYLPTADSPFQEMQSVIDRWEVGHEPSPALHPAFEQMGSRRNSSAGGNDKDPNRLKRLDPVFINKVIVGMQTIHFGKAVCVAFSDGSVEYRDRFTMQETYNELSLDRVMTLNQVGFTFAEGTPCLQVAFSPTNCSVAQIQEDGQVKWNGLHYPLGDIGNSNQDVRCSHRGSHSSRISCNVLPAFTRDWVNELVRMLKVPVDYSEEAHHEALVRNSSLQLCFSILNHLGFNGEFNPRSSSGKFAFLSLNIRNVVILITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDDPKFTELLQPRNYSEISNYLRSRADPSLQLLLCSATRGFLSAVCRRLTHLDQISHRAIEFYDRRAAMQNATDPSGQSKVATIALNKSYQRMQHIISNSHIKVQDFDHLLTTLTSDIRSTYQTAFAGLAAQAQQKNESNGTANTQQGQKQIDAQIRGAQIISELNLLLAAQPPAPFLTVLKKLFGQDLRAFRAQTDPSKLFFADLGLLEVDDVPRVLGARRAAARYVDVFRRVEMTNKAGPKEETPEEQLQQRGGRGGPLQWRRCVRCAAVMEDVFGSRPGFTFVLTQQRKCSCGGYWALLPKASIA
Length968
PositionTail
OrganismVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.08
Grand average of hydropathy-0.274
Instability index40.42
Isoelectric point6.53
Molecular weight107203.17
Publications
PubMed=21829347

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26041
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.91|      17|      53|      81|      97|       1
---------------------------------------------------------------------------
   81-   97 (32.05/18.11)	IAW..SKSGTIAYISPDGR
  135-  153 (24.86/12.62)	LAWaaTSSNELAVIDAAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.40|      33|     132|      24|      56|       2
---------------------------------------------------------------------------
   24-   56 (60.38/36.80)	AISAGDIPMNGPM...QVDGLDVDDLFGDGVNLTLP
  155-  190 (58.02/35.07)	AILAFSVSLNRPFltrKWDADHVDDLHAIAGCFWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     345.46|     109|     114|     466|     577|       3
---------------------------------------------------------------------------
  465-  576 (177.90/122.97)	VMT.LNQVGF..TFAEGTPCLQVAFSPTNCS....VAQIQEDGQVKWNGLHYPLGDIGNSNQDVRCSHRGSHSSRISCNVLPAFTRDwvNELVRMLKvPVDYSEEAHHEALVRNSSLQL
  577-  692 (167.56/105.26)	CFSiLNHLGFngEFNPRSSSGKFAFLSLNIRnvviLITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDD..PKFTELLQ.PRNYSEISNYLRSRADPSLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.82|      40|     325|     388|     430|       5
---------------------------------------------------------------------------
  388-  430 (62.83/49.58)	HPAFEqMGSRRnsSAGGNDKDPNRLKRLDPVFINKVIVGMQTI
  717-  756 (70.99/44.86)	HRAIE.FYDRR..AAMQNATDPSGQSKVATIALNKSYQRMQHI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26041 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPLMLDNPMETTTHDGDQVMNHDAISAGDIPMNGPMQVD
1
39










Molecular Recognition Features






MoRF SequenceStartStop




NANANA