<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26035
Description |
RNA polymerase I activation mediator protein |
Sequence | MGNADFFSWTGNHPEDRLSDAVIKNGYFDKAPVTQAETTSAKPAIFPALKHKNGLNLLSSIFVGVLNQRKHNGQVVAPSAFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGKGLLDHCLSKNVPTERAVWLVRCVGANDLRTVKRKGVNDPERPRSRHSSAALHQAHLTPTALALFLPRQLLITHDVLRCRETLLASIPIDNDAVLSAYKALNSRNEILIASNGKSQLANRQILIKQLDTTFQTLYTNELASSCWNVSEDKRMIVRTVLEWSTSFYRPGQARIYVAASLLRAWASTGVDITTAILESIGAAPPQGAIPKRLFYQLISELVRTGQFNVREYIIWLMGRGGMTSSLDTEPDAPCSTRLLIDLPLSALSSSLIATRANLLRRAAFDVAEEARDIDAAWNFIRHALGLSSNAEVSPVQRRPMPLAKICRAVSNSSRALQTEVGARLLRTFQTDEYESSSDIHLSPTAFNHARSILEAAKDFTTMAEMIKLTSRFPDADILASCADTVNVHLATFAAMNVARNLCDLLLERMKIVNDEQGVRVRPLLVALGALTSRLPGLANTSAHLRKELQQIDQSTAIDACSPVSDNMAARLQDAEGELNDEIERLLTGGTSLDRPTMDRLFHTVVTRLEGSWAKDSEKQHAYSALLARLRIFDTQHFDVRMTDWVHHVSIMKTRPTLFDIYPFLISLGCLGLSTIMTTTTVDPSKVVGGQIGCTSTYMQEVLQLVVSPLPPKNALSQEEAYRFYVQQRVAPQQHHRELAVLVRNSLIEYSKLQNSEMSTNAPLAQQDLQDDVLDLLRLLVLNDSPTTVQILGTKLADSPLSEVLASITTRLLAPTRDPSDPMTFETVLELANDFTLPFCQLKLSIGLAASKAGGSSGDEQPPSHVDMLSKALDQAVETKNMMWTSVLPYLSEEITDHLKRQAQTRLFSLVPSLKTMSTARDSSEDTIRLSESLLSVVEAIIRGRPALKATQLNMSMVEKLTELWELLAATEIVGKDLRMAIIEHWLPILLKFITLHTTANEPVLSPTQPASMKPPTTAAANDVRARMLVVLSGIMLELDTSAVRKQALVGNYDRRLSTSPYSSLIIYPKSHACSACAPSSSEGHFKRPLRLTLGYDIFSATPRLGWSNSCSRIDRRQRHRQMDRPDRRSPLACRVLRD |
Length | 1176 |
Position | Kinase |
Organism | Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.155 |
Instability index | 46.99 |
Isoelectric point | 8.92 |
Molecular weight | 130373.27 |
Publications | PubMed=21829347
|
Function
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.
ECO:0000256 ARBA:ARBA00002895
ECO:0000256 ARBA:ARBA00003744
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 309.00| 111| 389| 99| 272| 1
---------------------------------------------------------------------------
137- 272 (141.47/180.79) RAvwLVRCVGANDLRTVKrkgVNDPERPRsrhssaalhQAHLTPTALAlfLPRQLL.ITHDVLRCRE..TLLASIP.....................IDNDAVLS.........AYKALNSRNEILIasNGKSQLaNRqiliKQLDTTFQTLYTnELASScWNVSEDKR
452- 524 (87.47/32.40) RA..LQTEVGARLLRTFQ...TDEYESSS.........DIHLSPTAFN..HARSILeAAKDFTTMAEmiKLTSRFP......................DADILAS.........CADTVN.................................................
559- 657 (80.06/28.56) ....................................................RPLL.VALG........ALTSRLPglantsahlrkelqqidqstaIDACSPVSdnmaarlqdAEGELNDEIERLL..TGGTSL.DR....PTMDRLFHTVVT.RLEGS.WAKDSEKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 169.86| 56| 458| 369| 424| 3
---------------------------------------------------------------------------
369- 424 (93.17/51.24) DAPCSTRLL.IDLPLSALSSSLIATRANLLRRA.......AFD.VAEEARDIDAAWNFIRHALGL
821- 885 (76.68/40.97) DSPTTVQILgTKLADSPLSEVLASITTRLLAPTrdpsdpmTFEtVLELANDFTLPFCQLKLSIGL
---------------------------------------------------------------------------
|