<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26035

Description RNA polymerase I activation mediator protein
SequenceMGNADFFSWTGNHPEDRLSDAVIKNGYFDKAPVTQAETTSAKPAIFPALKHKNGLNLLSSIFVGVLNQRKHNGQVVAPSAFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGKGLLDHCLSKNVPTERAVWLVRCVGANDLRTVKRKGVNDPERPRSRHSSAALHQAHLTPTALALFLPRQLLITHDVLRCRETLLASIPIDNDAVLSAYKALNSRNEILIASNGKSQLANRQILIKQLDTTFQTLYTNELASSCWNVSEDKRMIVRTVLEWSTSFYRPGQARIYVAASLLRAWASTGVDITTAILESIGAAPPQGAIPKRLFYQLISELVRTGQFNVREYIIWLMGRGGMTSSLDTEPDAPCSTRLLIDLPLSALSSSLIATRANLLRRAAFDVAEEARDIDAAWNFIRHALGLSSNAEVSPVQRRPMPLAKICRAVSNSSRALQTEVGARLLRTFQTDEYESSSDIHLSPTAFNHARSILEAAKDFTTMAEMIKLTSRFPDADILASCADTVNVHLATFAAMNVARNLCDLLLERMKIVNDEQGVRVRPLLVALGALTSRLPGLANTSAHLRKELQQIDQSTAIDACSPVSDNMAARLQDAEGELNDEIERLLTGGTSLDRPTMDRLFHTVVTRLEGSWAKDSEKQHAYSALLARLRIFDTQHFDVRMTDWVHHVSIMKTRPTLFDIYPFLISLGCLGLSTIMTTTTVDPSKVVGGQIGCTSTYMQEVLQLVVSPLPPKNALSQEEAYRFYVQQRVAPQQHHRELAVLVRNSLIEYSKLQNSEMSTNAPLAQQDLQDDVLDLLRLLVLNDSPTTVQILGTKLADSPLSEVLASITTRLLAPTRDPSDPMTFETVLELANDFTLPFCQLKLSIGLAASKAGGSSGDEQPPSHVDMLSKALDQAVETKNMMWTSVLPYLSEEITDHLKRQAQTRLFSLVPSLKTMSTARDSSEDTIRLSESLLSVVEAIIRGRPALKATQLNMSMVEKLTELWELLAATEIVGKDLRMAIIEHWLPILLKFITLHTTANEPVLSPTQPASMKPPTTAAANDVRARMLVVLSGIMLELDTSAVRKQALVGNYDRRLSTSPYSSLIIYPKSHACSACAPSSSEGHFKRPLRLTLGYDIFSATPRLGWSNSCSRIDRRQRHRQMDRPDRRSPLACRVLRD
Length1176
PositionKinase
OrganismVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.05
Grand average of hydropathy-0.155
Instability index46.99
Isoelectric point8.92
Molecular weight130373.27
Publications
PubMed=21829347

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     309.00|     111|     389|      99|     272|       1
---------------------------------------------------------------------------
  137-  272 (141.47/180.79)	RAvwLVRCVGANDLRTVKrkgVNDPERPRsrhssaalhQAHLTPTALAlfLPRQLL.ITHDVLRCRE..TLLASIP.....................IDNDAVLS.........AYKALNSRNEILIasNGKSQLaNRqiliKQLDTTFQTLYTnELASScWNVSEDKR
  452-  524 (87.47/32.40)	RA..LQTEVGARLLRTFQ...TDEYESSS.........DIHLSPTAFN..HARSILeAAKDFTTMAEmiKLTSRFP......................DADILAS.........CADTVN.................................................
  559-  657 (80.06/28.56)	....................................................RPLL.VALG........ALTSRLPglantsahlrkelqqidqstaIDACSPVSdnmaarlqdAEGELNDEIERLL..TGGTSL.DR....PTMDRLFHTVVT.RLEGS.WAKDSEKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.86|      56|     458|     369|     424|       3
---------------------------------------------------------------------------
  369-  424 (93.17/51.24)	DAPCSTRLL.IDLPLSALSSSLIATRANLLRRA.......AFD.VAEEARDIDAAWNFIRHALGL
  821-  885 (76.68/40.97)	DSPTTVQILgTKLADSPLSEVLASITTRLLAPTrdpsdpmTFEtVLELANDFTLPFCQLKLSIGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26035 with Med12 domain of Kingdom Fungi
Unable to open file!