<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26017
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDRISSAPFRTGPPSPSPSSPAPFTSLKENTYSTIPPEQIPQTPTSPPLMSVSATNDASNLANLQASSQATSQTASLSSPPSTAPMTTQNSQQPTAGATNSFPTPASSVGPDHMNKSFGTDFSETGASNTTGASAVPTQQSEHRRTDHNRDSKSARARQAVKDSQQLGESGHAPHGSAMDLDTERPAQTNANWLSLDSLQKDFSSAFHLCKSSHIATGPDPSVDLISLYGLGPVAKSVARNDPVTGEKINRLRKSYEGKLKGLGLAGRNKAVKHDPATPGGLRQMTMWPEEEWQNQKVFGKEIKVADMDSALYNLQMKAMKMEPGTVPNNDYWEDVLGHDKPTKNANAGEGAKKTHPSASAPRAVSQPNGTPVPAEPERSRPSRGRKRHYDDNSFVGYGEGYADDDDDAAIYSNGEGGGKKKRKKDHVPRIPAPSDRGGSYGVGMFGIGAR |
Length | 452 |
Position | Head |
Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus>
Aspergillus subgen. Nidulantes.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.882 |
Instability index | 50.03 |
Isoelectric point | 8.67 |
Molecular weight | 48118.41 |
Publications | PubMed=16372000
PubMed=19146970
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 125.93| 38| 41| 20| 57| 1
---------------------------------------------------------------------------
20- 57 (66.39/30.24) SSPAPFTSLKENTYSTI....PPEQIPQTPTSPPLMSVSATN
60- 101 (59.53/26.36) SNLANLQASSQATSQTAslssPPSTAPMTTQNSQQPTAGATN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 217.15| 71| 92| 168| 259| 2
---------------------------------------------------------------------------
113- 187 (115.22/74.11) DHMNKSFGTDFSETGASN.TTGAS.AV.........PTQQSeHRRTDHNRDSKSARARQAVKDsqqLGESGHAPHGSAMDLDTERP
198- 280 (101.93/72.57) DSLQKDFSSAFHLCKSSHiATGPDpSVdlislyglgPVAKS.VARNDPVTGEKINRLRKSYEG..kLKGLGLAGRNKAVKHDPATP
---------------------------------------------------------------------------
|