Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTFIDRRFERLEKALANLIDSVTKYHPSTVHAQELEAADNELSKGLEEVQTHQNNYLRIQQLRESSAALDAQIRDTISSLATTRKDIVTTHATTFSAEPNYPIAYEELLNYARRISKTTMPPAGTINPVSPSPPEGQTPAGQTPGPDSQNASVMTPSAPPTSQVQSPAVMNGTPQVSQEPATQQTTTSANTNLPEGWTQFLNPLSGQLFFPWPQEDKIRAGSLASNQVLMEQGIEPKGYDPVEEEARKQREEEERKQKEEEARLAQEERERKIREDRERQRIERERQREKEQEAWRRASLVGGPSGAPGETKSTAGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 340 |
Position | Middle |
Organism | Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.056 |
Instability index | 56.66 |
Isoelectric point | 4.79 |
Molecular weight | 38121.29 |
Publications | PubMed=19714214 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26013 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.24| 19| 23| 244| 264| 1 --------------------------------------------------------------------------- 244- 262 (32.19/15.58) EEEARKQREEEERKQKEEE 268- 286 (33.05/11.27) EERERKIREDRERQRIERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.23| 16| 23| 132| 151| 2 --------------------------------------------------------------------------- 132- 151 (28.17/19.68) PSPPegqtPAGQTPGPDSQN 157- 172 (29.07/11.91) PSAP....PTSQVQSPAVMN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 78.16| 21| 89| 91| 111| 3 --------------------------------------------------------------------------- 91- 111 (38.66/27.87) THATTFSAEPNYPIAYEELLN 183- 203 (39.50/28.66) TQQTTTSANTNLPEGWTQFLN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 75.94| 24| 26| 13| 36| 4 --------------------------------------------------------------------------- 13- 36 (37.54/26.54) EKALANLIDSVTKYHPSTVHAQEL 40- 63 (38.40/27.30) DNELSKGLEEVQTHQNNYLRIQQL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QEAWRRASLVGG 2) TKSTAGPPQQKAQFQFTNLDDLDDD | 293 312 | 304 336 |
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