<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26013

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDTFIDRRFERLEKALANLIDSVTKYHPSTVHAQELEAADNELSKGLEEVQTHQNNYLRIQQLRESSAALDAQIRDTISSLATTRKDIVTTHATTFSAEPNYPIAYEELLNYARRISKTTMPPAGTINPVSPSPPEGQTPAGQTPGPDSQNASVMTPSAPPTSQVQSPAVMNGTPQVSQEPATQQTTTSANTNLPEGWTQFLNPLSGQLFFPWPQEDKIRAGSLASNQVLMEQGIEPKGYDPVEEEARKQREEEERKQKEEEARLAQEERERKIREDRERQRIERERQREKEQEAWRRASLVGGPSGAPGETKSTAGPPQQKAQFQFTNLDDLDDDDDDD
Length340
PositionMiddle
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii.
Aromaticity0.05
Grand average of hydropathy-1.056
Instability index56.66
Isoelectric point4.79
Molecular weight38121.29
Publications
PubMed=19714214

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26013
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.24|      19|      23|     244|     264|       1
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  244-  262 (32.19/15.58)	EEEARKQREEEERKQKEEE
  268-  286 (33.05/11.27)	EERERKIREDRERQRIERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.23|      16|      23|     132|     151|       2
---------------------------------------------------------------------------
  132-  151 (28.17/19.68)	PSPPegqtPAGQTPGPDSQN
  157-  172 (29.07/11.91)	PSAP....PTSQVQSPAVMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.16|      21|      89|      91|     111|       3
---------------------------------------------------------------------------
   91-  111 (38.66/27.87)	THATTFSAEPNYPIAYEELLN
  183-  203 (39.50/28.66)	TQQTTTSANTNLPEGWTQFLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.94|      24|      26|      13|      36|       4
---------------------------------------------------------------------------
   13-   36 (37.54/26.54)	EKALANLIDSVTKYHPSTVHAQEL
   40-   63 (38.40/27.30)	DNELSKGLEEVQTHQNNYLRIQQL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26013 with Med4 domain of Kingdom Fungi
Unable to open file!