<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26007

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFHPQTPQSPSQFSSGTSEPALGVATSMTATATATTLPTPAHSVSGSASHHDVVMADDSPHKRKRSVDDSGDREQKKVHVEESKLGIEDLHLDVGKKYLLCQTPHLESLPRISEDLYDMFNLTGLAAEVAREKPNGEKNALRSSYTGHIKRLGIAGHFKVQKVENRGENDPQEESDFAQILHLGDEDWSNSFVRGREISLGLSQSSLSSLGRAVTMAKGSIKKDVWDTSVLGLQSSNGELKQPSSARPTAPNTPLNVPGAVGRLKAQGASANDPNRPRRNIKKRTYGDSSFEGYGEGYPDDDNAMEGGYSTGEGEGSQKRRKKNPGNASPYPSAMRQQSYGPGMVGA
Length348
PositionHead
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii.
Aromaticity0.05
Grand average of hydropathy-0.823
Instability index50.71
Isoelectric point6.85
Molecular weight37458.92
Publications
PubMed=19714214

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.42|      28|      28|     127|     154|       1
---------------------------------------------------------------------------
  127-  154 (46.58/30.85)	AA..EVAREKPNGEKNALRSSYTGHIKRLG
  156-  185 (42.84/27.80)	AGhfKVQKVENRGENDPQEESDFAQILHLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.73|      15|      22|     239|     258|       2
---------------------------------------------------------------------------
  239-  255 (24.47/25.03)	GELK.QPSSArpTAPNTP
  263-  278 (25.26/ 9.36)	GRLKaQGASA..NDPNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.03|      14|      21|     281|     294|       3
---------------------------------------------------------------------------
  281-  294 (24.65/13.11)	NIKKRTYGDSSFEG
  304-  317 (25.38/13.69)	NAMEGGYSTGEGEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26007 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLQSSNGELKQPSSARPTAPNTPLNVPGAVGRLKAQGASANDPNRPRRNIKKRTYGDSSFEGYGEGYPDDDNAMEGGYSTGEGEGSQKRRKKNPGNASPYPSAMRQQSYGPGMVGA
2) MSFHPQTPQSPSQFSSGTSEPALGVATSMTATATATTLPTPAHSVSGSASHHDVVMADDSPHKRKRSVDDSGDREQKKVHVEESKLG
233
1
348
87










Molecular Recognition Features






MoRF SequenceStartStop




1) AQILHL
2) SFEGYGEGYP
3) SQKRRKKNPGNASPYPSAMRQQSYG
179
291
318
184
300
342