<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26004

Description Predicted protein
SequenceMTSRTPMGVQPRPPQRSVSSSSLPVQRPPNQRTLSGQQHQFLPASPVRKDSSFIDLTGDSTDATPNRYNTTPRRGGSRLRLELSHDASAGHIPATESPQSLTPSRLPTNTDPFSTAAVSPAASNSASSTMMPMPTRRPPPTQPRSAPRITTAAPAPAKKDTRPKPYTVEVPPLAPRYLTTNRSDIPGRTPVDPFSKGLNSGYADFFPWNGSHHEDEWSSDAITKGTWDKVNLNVAETSSAKLAIFPALKQKSGFNALSTIFMGVLTQRRHRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRAFKRKGVNGAFVMGGELKWARDWTGLVEQFVDSVVNGFGEMDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGVENSPQSKIPMWILIAQIYWKDLLRSRKYGRRLVFALLSHLHVIHNDPDQDLLVQLSSRLSSLLGSLVRNNPESFIYPSAWPRYRDTLQAALGLDHEENQTAIQTIHSRNSRLLVSSTASPPAGRSQLVKLLDAALKGPVDNLTAKCWAMSENKPLIMKTVVEWATSFHRPGLAKVFVAARLIRQWSQFRVNPTTPILEVLDGVAIHDKTRKQLVYHLVTELVRTGHFSVSQYMQWTIARGGYHDEADIDPVEGPCSSRLLVELPVYALSEKKRGERGNLLRRAGNYSVVDEQQDIANAIKYVKHTLGLPLPPGDPLSEKKPMSLKKLLQRIGSSSNALRSCIGAHLRDYLINQLSAKTHPPLSLAMYTSIRGIMETAEDFTMLSDILGACSKTADADVLASCADTISSNLQIFFALGSADDLFNSLIERLKSINEEQGIVHRPLLAALSSLAQRMTGHEEMASELHRELLQCDRNNAIDACSPVSDIMSTPAQHAESEMAEEIEKLLASGTRLDPPTMNRLFRTIIPRLERGWAKKDETRRVFGMLLARIRGFDAQHFDKLMTDWTSHIRSLQNRPLLSDLFPLLVSSGCLAMPIIMSTASAPSASMQNVTPEMVSTQHGSATYLQELLQLVITSLPTTTGLSPEESYRFRTEQKCAKFEQPKGLLNLVRNALLEYSALRSHCNVVELPLDNTSCQESLLETLRTLVLVDSTAVSNALSIKSLPAEAVGIVRKVTTKLLIPGDPGETQISFDQILQIANELTLPFCQLKLNLDLAMPQPNSNEVSDQSSSRFELFAKSMERAIEAGNIMWTSLLPCLSDDITQHLKSQAQAGFLDLIPSLKFPSSTETGSRQPIHMAENLLGVVEAIISGQAPPKMAQLSLGMVDKLTDLWEIIAAGPQERSNIHADVLEHWLPAILRFITLHSLSSEPPSAPLPTATATRPPMAAVHDIRARIILVLCGLLLELEQLPAATIGSLPQQVFDIAILLVDALPEDLRVNCSKAVLLTPGGLPHPGTSSDPRLYYLFSSPQPAASDNLMLSHREKAASPHSAVARGMGAQYGIGPAVQERLSPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKIQ
Length1531
PositionKinase
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii.
Aromaticity0.06
Grand average of hydropathy-0.226
Instability index47.97
Isoelectric point8.66
Molecular weight168770.39
Publications
PubMed=19714214

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26004
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     334.02|      83|     252|     987|    1072|       1
---------------------------------------------------------------------------
  987- 1072 (130.99/91.21)	LMTDWTSHIRSLQNRPLLSDLFPLLVSSgcLAMPIIMSTASAPSAS...MQN....VTPEMVSTQhGSATYLQELLQLV..ITSLPTTTGLSPEE
 1114- 1179 (88.98/51.66)	LPLDNTSCQESLLE..TLRTL..VLVDS..TAVSNALSIKSLPAEAvgiVRK....VTT.................KLL..IPGDPGETQISFDQ
 1243- 1326 (114.05/68.44)	LSDDITQHLKS.QAQAGFLDLIP...S...LKFPSSTETGSRQPIH...MAEnllgVVEAIISGQ.APPKMAQLSLGMVdkLTDLWEIIAAGPQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.46|      23|      80|      92|     114|       2
---------------------------------------------------------------------------
   54-   73 (24.25/ 8.82)	IDLTGDSTDAT....PNR..YN..TTPR...
   92-  114 (43.86/22.68)	IPATESPQSLT....PSR..LP..TNTDPFS
  119-  145 (33.11/15.08)	SPAASNSASSTmmpmPTR..RP..PPTQPRS
  170-  195 (29.23/12.34)	VPPL.APRYLT....TNRsdIPgrTPVDPFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.32|      43|     249|       7|      51|       3
---------------------------------------------------------------------------
    7-   51 (73.79/41.18)	MGVQPRPPQRS.VSSSSlpVQRPPNQRTLSGQQHQ.FL.....PASPVRKDS
  262-  311 (62.53/29.32)	MGVLTQRRHRGqITAPS..TFKPPPRVTLTDTKREvWLkdlanPAISLRRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.45|      19|     248|     340|     358|       4
---------------------------------------------------------------------------
  340-  358 (32.81/17.41)	LAK.CVGANEIRAFKRKGV...N
  570-  590 (21.12/ 8.95)	.AK.CWAMSENKPLIMKTVvewA
  598-  617 (27.53/13.59)	LAKvFVAARLIRQWSQFRV...N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.01|      32|     249|     408|     439|       5
---------------------------------------------------------------------------
  381-  418 (41.03/27.78)	VDSVVNGFGEMDwKNRVTYAIrLatnlYSEQLLDRDHY
  419-  454 (53.98/39.19)	LDWVVSGVENSP.QSKIPMWI.LiaqiYWKDLLRSRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.75|      42|     250|     621|     703|       6
---------------------------------------------------------------------------
  621-  666 (63.22/74.97)	PILevlDGV.....AIHDKTRKQLVYHLVTELVRTGHFSVSQYMqWTIARG
  752-  798 (65.53/48.83)	KLL...QRIgsssnALRSCIGAHLRDYLINQLSAKTHPPLSLAM.YTSIRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.21|      63|      98|     810|     872|       7
---------------------------------------------------------------------------
  810-  872 (104.46/73.77)	SDILGACSKTAD.ADVLASCADT.ISSNLQIFFALGSADD......LFNSLIERLK...SINEEQGIVHRPLLA
  901-  974 (85.75/59.07)	NNAIDACSPVSDiMSTPAQHAESeMAEEIEKLLASGTRLDpptmnrLFRTIIPRLErgwAKKDETRRVFGMLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.51|      18|      98|    1348|    1379|       8
---------------------------------------------------------------------------
  730-  748 (31.96/ 8.96)	HTLGlPLPPGDPL....SEKKPM
 1349- 1370 (29.56/31.12)	HSLS.SEPPSAPLptatATRPPM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26004 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRTPMGVQPRPPQRSVSSSSLPVQRPPNQRTLSGQQHQFLPASPVRKDSSFIDLTGDSTDATPNRYNTTPRRGGSRLRLELSHDASAGHIPATESPQSLTPSRLPTNTDPFSTAAVSPAASNSASSTMMPMPTRRPPPTQPRSAPRITTAAPAPAKKDTRPKPYTVEVPPLAPRYLTTNRSDIPGRTPVDPF
1
194










Molecular Recognition Features






MoRF SequenceStartStop




1) RLYYLF
1446
1451