<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26001

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVEEGTLEPMALQKSRIPGNTTQNPAANPPSANPTTDSSQRNSMLSPTQAMGGNLQEGDAQLSAQPTETKAAQPVPKTIYENFIVAILFSVSFAFCSRSMAVPLNYRTVLIPPPLGDASEQERGSLPSDPVIGTFKTYLTTTGSLIISLYFSYCRSIASVEDAVSTDPISPSSPILAAPYGVLATKQSSSNGDHGSVADHSLSQTPNTQAVAVRTVVDAQDSIWKHSCLRALQHCGLNPSNFKAGSWINLLISKPPSPDAENDPKRTRATVPWPGALCFRKRPLEVSTTCRIGDTMLSGHEECHDPLGNARGWFNSTSEREEKVSKRKAERVLAIPREVNSGETQPQRVNGQSPLTLRRPSTAAAGVMYPTPPDAIQQHLGVTPSIDGTISSPGNPPPTAAAVDIDTAMPTVTPMADPDNDGWDGHHESKRDRSDSNLLGESENILSDMGEDVFGDHNITEDDFDFFDQPDGNDLDITMGDLQPNPIPPPPQTLPPVVVKQPEPPKPIEDHTGPKSKPGVDDSVFAKPELKHARSSLNDDHRAKPERPNSTKRGSSPFDPATVFKRVRASLSSPVQDSRNPSPIARRKSSIFEKVEFDPKLPLINKKYEQGGAFDFSRDQEAERLKRDSNTLSDAEYLERHGKLKPSLRKLSLPASTFIKGFTGMDVSNNTSPTRINGNMSGSEDSDLESDQEDSSSMSGGPTSPVKSSVKRAVVDDDVLSQATSTKEAELSEEPTEEQLAIELPRLSKPESPELLLSRFFSEPEPLNVDIGLSNQDFVEIAQIITEQAATGRLEIGIDRKPDATTGLTTIRGQEVNVARTSLQLLHSVVPSSLGSASPVRLKGLLDIPDLPLVGQPNRLQPRPAPGRDPNSEQMRPNNLYQIPVPHLEVRRSETKLSVLPSSVSFWESLGLAPSWGTKDIASLCIFPGWKGMPDHVGTFLDRLKSVYESLKLGTFNKLALSGEMKDGVLPYEVDRISTSPDATITGHGSALVESMEVLRGSLSEWKSKQKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLATRRETPQNELVLQLVSSDLISSTTSLVIPSPSEMIKLCMETYDRCTLFLDPEFGGPTPAPAIMLEQPLPRIIDFKLGSTPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQQQATASYSVTRTRTPDRSTAQQKAAILVEIWATTLAMMSIWKVHWRVVVTKSGPMDQREVEWWQTASKLDDKASFTMVLMTVDTNPSLQLIPPTVKIPHTATSAFYSTPVSTPQASIVSPEQTTTPATPMRDNNPPGATPGAESAGEIDGDSFLIDATDQTWGAVVGHRLGNSTTLLEVRPALVSGYLIKRTGTRIEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1426
PositionKinase
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii.
Aromaticity0.06
Grand average of hydropathy-0.434
Instability index50.48
Isoelectric point5.28
Molecular weight155458.15
Publications
PubMed=19714214

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26001
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     894.19|     240|     247|     632|     878|       1
---------------------------------------------------------------------------
  424-  628 (220.03/112.67)	..........................................................D...GHHESKRDRSDSNLLGESENILSD..MGEDVFGDHNITE....DDFDFFDQPDG..NDLDITMGD..L.................QPNP....IPPPPQ...TLPPVVVKQPEPPK.PIEDHTGPKSKPGVddSVFAKPELKHARSSLNDDHRAKPE.....RPNSTkrgsspfdpatvfkrvraslsspvqdsrnpspiarrkSSIFEKVEFD.PKLPLINKKYEQGGAFD.......F.......SRDQEAERLKRD
  632-  878 (370.23/215.00)	LSDAEYleRHGKLKPSLRKLS.LPAS.TFIKGFtGMDVSNNTSPTR...INGNMSGSED...SDLESDQEDSSSMSGGPTSPVKSS..VKRAVVDDDVLSQATSTKEAELSEEPTE..EQLAIELPR..LS..KPESPELLLSRFFSEPEPlnVDIGLSNQDFVEIAQIITEQAATGRlEIGIDRKPDATTGL..TTIRGQEVNVARTSLQLLHSVVPS.....SLGSA.....................................SPVRLKGLLDiPDLPLVGQPNRLQPRPA.......P.......GRDPNSEQMRPN
  880- 1134 (303.93/159.58)	LYQIPV..PHLEVRRSETKLSvLPSSvSFWESL.GLAPSWGTKDIAslcIFPGWKGMPDhvgTFLDRLKSVYESLKLGTFNKLALSgeMKDGVLPYEVDRISTSP.DATITGHGSAlvESM..EVLRgsLSewKSKQKNLVIYFVYSPDNP..ASIIEACTAFYRCFDEYSDLLATRR......ETPQNELVL..QLVSSDLIS.STTSL.....VIPSpsemiKLCME.....................................TYDRCTLFLD.PEF...GGPT...PAPAimleqplPriidfklGSTPSQSLMHEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.23|      10|      22|     315|     324|       2
---------------------------------------------------------------------------
  315-  324 (15.73/ 9.81)	NSTSEREEKV
  340-  349 (17.51/11.99)	NSGETQPQRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.57|      25|    1021|     252|     276|       3
---------------------------------------------------------------------------
  252-  276 (46.65/22.57)	ISKPP....SPDAENDPKRTRATV..PWPGA
  353-  372 (26.59/ 9.11)	.........SPLTLRRPSTAAAGV..MYPTP
 1252- 1269 (22.28/ 6.22)	..........PPTVKIPHTATSA...FYSTP
 1270- 1298 (31.05/12.10)	VSTPQasivSPEQTTTPA.TPMRDnnP.PGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.49|      36|     756|     379|     419|       5
---------------------------------------------------------------------------
  379-  419 (62.58/44.80)	HLGVTPSIDG...TISSPGNPPPTAAavdidTAMPTVTPMADPD
 1138- 1176 (60.90/33.57)	HVGYAESLDGrwiTAAWTDNRGQQQA.....TASYSVTRTRTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.20|      14|     428|     122|     136|       6
---------------------------------------------------------------------------
  122-  136 (22.61/17.62)	ERGSLPSDPVIgTFK
  552-  565 (27.58/16.12)	KRGSSPFDPAT.VFK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26001 with Med13 domain of Kingdom Fungi
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