<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26000

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNDLPDEIVHITQGYISLSTFLTRLAQSTHNNLEDQITKMAKMPLPVAAMNGNSSIPNNDIDDASNENIIKKKSILDFAYKEHQRWVKALVITEWSRKAEMVSKLIDLRAHIMKQQVLTDTAFDTMVNVKRDLTFARMPSPDLKTALQVLSTGKAAWMPDLQYIEPPPLTLQEQSQWMSDVNTLLSLRLNLEDFDKIPYHFRNYDIKSGRVTFKVPGEFEVDLTIADEDFEKQFWFIDLRFTFKPSAAAIPESLKDYLERHVNGVLSTEGLLGCYQFLHEMVLTHKLNELRRQANQLSKGSWTGTLKVEPLNRALAIQYWTSRAPPTSPKSWVLVAVNSGRKANGEANAKSSSFLQAKWYRDNKEVKDVEVPFDANILSAEALLKTVIGLHIDFLLSSIHDKLMATPRFRNREAAMVLRSCQEDPAASSLSMQVGYKDSISLLIEPTTGVFAVKPHSKFIYQHELQLNNGKSPADDGVVCLENVRCAIMEEELNRRGSTMGWSVQKSPLNNEELRSATKNREWTKTIWLQRAGWRPTWFIMVVLSLSGDEWWLLEVDRNTPGPVVKLTAKLPFNKGYPSLHNTFWNNMTVFATGMIAQAIDMRELHKQQIKFKPNETKSWSLPRQVRLPSIEIALSGIFPSMVFDSSEKESSKASSNRDLEQLGLASITQPATGLKLSTIEPWANDIVSISFKGAQLPEAEPAASEGANPQDVKSDTPLVCISDAIIKVRRPAKFTSIKGALVGQDVSYNLLKGEFRLRMRHSLGQSILESLKSRVKAVDRFVSFVESMDKAKGSIQSETVSLQEVVFSYRDQSNDSPNDTTATGRRWRVALNLSKDVIDIKMEKGNPHLRVVDLMQNLVNSDGGIEALMAWLPTSLPALEAIQKTEELWADIKARNQGQFQFSMNSLEWMTLDYFISGPGQMQRRVAFEGRIKSRRGEPWWHIWRVPVANDTSVPNDDLTAALKHVWEGKGDDWTGLVTSAVGGPSRGVVGILKAIDDAIRPMIGQGNSEVVVLE
Length1016
PositionTail
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium solani species complex> Fusarium vanettenii.
Aromaticity0.08
Grand average of hydropathy-0.324
Instability index43.46
Isoelectric point7.04
Molecular weight114310.36
Publications
PubMed=19714214

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     273.73|     100|     205|     584|     687|       1
---------------------------------------------------------------------------
  584-  642 (80.82/49.08)	...............................................................................................................................................FWNNMTVFATGMI.AQAIDMREL...HKQQIKFKPNET....KSWSLPRQVRLPSIEIALSGIFPSM
  643-  687 (31.29/26.26)	VFDSSEkesSKASSNRDLEQL.GLASITQPATGLKLSTIEPWAnDI....................................................................................................................................................................
  785-  850 (57.05/31.89)	..............................................vsisfkgaqlpeaepaaseganpqdvksdtplvcisdaiikvrrpakftsikgalvgqdvsynllkgefrlrmrhslgqsileslksrvkavdrfvsFVESMDK.AKGSIqSETVSLQEVvfsYRDQSNDSPNDTtatgRRWRVALNLSKDVIDIKMEKGNPHL
  852-  948 (104.57/67.42)	VVDLMQ...NLVNSDGGIEALmAWLPTSLPALEAIQKTEELWA.DI..................................................................................karnqgqfqfsmnslEWMTLDYFISG...PGQMQRRVA...FEGRIKSRRGEP..wwHIWRVP...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     394.90|     100|     205|     241|     340|       2
---------------------------------------------------------------------------
  241-  340 (167.28/115.49)	FT..FKPSAAAIPESLKDYLERHVNGVLSTEGLLGCYQFLH.EMVLT..H.KLNELRRQANQLSKGSWTGTLKV...EPL.....NRALAIQ..YWTSRAPPTSPKSW.VLVAVN.SG
  351-  448 (92.28/59.97)	SSsfLQAKWYRDNKEVKDVEVPFDANILSAEALLKTVIGLHiDFLLSsiHdKLMATPRFRNR....EAAMVLRScqeDPA.....ASSLSMQvgYKDSISLLIEPTT...........
  451-  548 (135.34/91.85)	FA..VKPHSKFI...YQHELQLN.NGKSPADDGVVCLENVR.CAIME..E.ELN...RRGSTMGWSVQKSPLNN...EELrsatkNREWTKT..IWLQRA.GWRP.TWfIMVVLSlSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.80|      14|     421|     549|     563|       3
---------------------------------------------------------------------------
  549-  563 (25.74/18.87)	DEWWLLeVDRNTPGP
  973-  986 (26.06/14.10)	DDWTGL.VTSAVGGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26000 with Med14 domain of Kingdom Fungi
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