<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25985

Description RNA polymerase II transcription mediator complex subunit
SequenceMAAQPEVPLEEITWRSPQHVQMMGGYLHSNNILFYFAESPFFDKTSNNASLAVQASYNENFRHFLETREAFEGRLKGMQGLEFMVVHDPLQEAAAAGGIQQQRVQQEPSNVWVIRKQMRKKRAGLGSGPAGSDDEIQVLATYFVVGDSVYMAPSVLKIVGSRILSTVTSLTKALSAASPLPIFSPSYGHTYMPPVPKALESSRPGVQQSDQQSVADTPMPDALLQSKDASALSSTAEQPSASTSVSPLTSSSTTMQDSRSLIEAFNLLSRYGDEYMDDAPLLGEPGSFIIGKTSTEPLVVGMRQPVNSEASKAPTPAPSTGVGGSMSKPGTPAATGTTTALSAIKTDPATIGVGKTGKGGEKSPTTPGGMKERTKRRKSKILSTAVVSSATGPGAGVS
Length398
PositionHead
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.06
Grand average of hydropathy-0.308
Instability index58.83
Isoelectric point7.85
Molecular weight41972.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364143

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25985
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     254.88|      63|      65|     197|     260|       1
---------------------------------------------------------------------------
  116-  190 (77.51/28.38)	KQMR.KKRAGLGSGPAGSddeiqvlatyfvVGDSvYM...APSVLKIVGSR.ILSTVTSLTKAL.SAASPLPIFSPSYGHT.
  197-  259 (99.76/38.81)	KALE.SSRPGVQQSDQQS............VADT.PM...PDALLQSKDAS.ALSSTAEQPSAS.TSVSPLTSSSTTMQDSR
  263-  326 (77.60/29.14)	EAFNlLSRYGDEYMD.................DA.PLlgePGSFIIGKTSTePLVVGMRQPVNSeASKAPTPAPSTGVGGSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.60|      24|      33|     329|     359|       2
---------------------------------------------------------------------------
  329-  353 (37.49/25.35)	PGTPAATGT..........TTALSAIKTDPATiGV
  364-  397 (35.11/10.30)	PTTPGGMKErtkrrkskilSTAVVSSATGPGA.GV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25985 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KTSTEPLVVGMRQPVNSEASKAPTPAPSTGVGGSMSKPGTPAATGTTTALSAIKTDPATIGVGKTGKGGEKSPTTPGGMKERTKRRKSKILSTAVVSSATGPGAGVS
2) PPVPKALESSRPGVQQSDQQSVADTPMPDALLQSKDASALSSTAEQPSASTSVSPLTSSSTTMQD
292
193
398
257










Molecular Recognition Features






MoRF SequenceStartStop




1) PTTPGGMKERTKRRKSKILSTAVVSSAT
364
391