<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25984

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHATPAPFRAKPPSPSSHAVDSAKLHQLYLQNRPKDQIPHTPTSPPLMSVSAQNYASSFSTTQTSPPKTLQIASLPPSPSSVPMCSQISQQPTVTSTTSLSTPASSAGGLFTSNHMMREAEDTSKNVTTDPRKDGESYVGKGIGLDLMDIDTSDHRRTDHDRQKRGLDQSFGGNTMDLDYKATSSTQEEELSLAALQQDIGTAFHLCKSSYTVSGPNPSLDLVSLYGLGPVASSVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKAEPGTPGGLKYLTLWPEEEWQNQKVYGKDIRVAEPDSSFFKQQLKAMKMEPGSLPNHEFWEDALGHEKSSKALAANDTSLAKAAGTVPGSIRQPMHANGTPTAISTPATENTRPKRAGKKRSYNDSSFVGYGEGFPDDELDLDSGRYSNSEEGARGPGKKKRKKDHISGVSPTLTERAGSYGVGMFGVGAR
Length462
PositionHead
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.06
Grand average of hydropathy-0.745
Instability index46.25
Isoelectric point8.87
Molecular weight49622.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25984
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.88|      23|      32|      15|      46|       1
---------------------------------------------------------------------------
   13-   45 (29.12/39.86)	P..........pSPSSHAVDSaklhqlylQNRpKDQIPHTPTS
   46-   66 (29.23/16.26)	P..........pLMS...VSA........QNY.ASSFSTTQTS
   67-   94 (21.54/ 9.93)	PpktlqiaslppSPSSVPMCS..............QISQQPT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.92|      25|      30|     123|     152|       2
---------------------------------------------------------------------------
  123-  147 (45.50/31.83)	DTSKNVTTDP..RKDG..ESYVGKGIGLD
  152-  180 (38.42/17.24)	DTSDHRRTDHdrQKRGldQSFGGNTMDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.47|      15|      30|     227|     255|       3
---------------------------------------------------------------------------
  227-  245 (22.87/36.49)	YGLGPVAssvaRTDPVTGE
  259-  273 (26.60/ 8.18)	KGLGLAG....RNKPVKAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      14|      30|     184|     197|       4
---------------------------------------------------------------------------
  184-  197 (21.36/10.94)	TSSTQEEELSLAAL
  213-  226 (23.63/12.80)	TVSGPNPSLDLVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.76|      31|      38|     280|     310|       5
---------------------------------------------------------------------------
  280-  310 (56.29/41.05)	LKYLTLWP.....EEEWQNQKVYGKDIR.VAEPDSSF
  315-  351 (43.48/30.02)	LKAMKMEPgslpnHEFWEDALGHEKSSKaLAANDTSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25984 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELDLDSGRYSNSEEGARGPGKKKRKKDHISGVSPTLTE
2) MSHATPAPFRAKPPSPSSHAVDSAKLHQLYLQNRPKDQIPHTPTSPPLMSVSAQNYASSFSTTQTSPPKTLQIASLPPSPSSVPMCSQISQQPTVTSTTSLSTPASSAGGLFTSNHMMREAEDTSKNVTTDPRKDGESYVGKGIGLDLMDIDTSDHRRTDHDRQKRGLDQSFGGNTMDLDYKATSSTQEEELSLA
3) SKALAANDTSLAKAAGTVPGSIRQPMHANGTPTAISTPATENTRPKRAGKKRSYNDSSFVG
410
1
341
447
195
401










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHIS
2) MSHATPAPFRAK
3) SSHAVDSAKLHQLYLQN
430
1
17
439
12
33