<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25982

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVLDGFFHIFWRIYSRVAPKSRGSQFDLLESSGLRNSNEVRSALLALRNDGCYVSQLANRSELWIFSPNPNFEALVQDSGNGKSDEDLIVAGKATFLNVASGVNTAAEVKHCLLSDPDSSIFESAATQNKLTTNCSEYAQLKSLTTYSAFYEGFISAISKALTLHFTKQQKVIPLGTRTLYSSLEENGYQSGDDDLPFSRKSTSFLSILDINVTSKGRLAISLCTLPQPGLEQLLRDSESEIIDARLSDDVWIAPSGTLCRLTSTGEYQSTQSNIVSPGHIATTPHEVEPLASKMKADKREWKRCVAEWLRIFGLQLNDPEAELWVEVEVNALDRQLYILFSKSNWNHQKSSPFIRILWPLKLCFTRSRSKMTGPANPTEFFSGQAESPLQLAERWVKEPCPIRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARVINLPEAQLASAVYPTPPGGGLAQGMGAGIVSEGLGTSAIDTLNYPPTQSEQIYNETVGPAAYFRGTSELLPTGLDPTTSELGIGSGLYDTAADEDFFGDMDVANFDTKGITEADFNFFDEPEFTGLTGDLDMQTSEPEAVQHDTEANFTAPDSADTAMSITEPSPSNYDQNHLTRSEHDTIKQPAFSSLITTGDEDHICKETTELSQIISTDDSQKKRPISPPLSPVQIKKILSPDVSTNLRLTPFKSDISRLRIAPNQYSPVIFQPRLCSSDQKYKIDGKFWFTPGKRYITSNLGGSPSGIPTIGFPEKGRKVRPKPLPILTSLHPLISDNTLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRNRDYEVEGNSTPSPLDILTQTSDLDKGPLSEHQFALLGAFLSEGVDWPLTGYFSRKQNDIFPVFLRREDLLQTAQLVVDQITQSSFCHIRDDLHKPEWADWDDILSRSLFDNIDGLGHLSKLDLRTYVTLEDGSNPRKDGPSIRPNLTGSICKICPPHIKVHRGNSYLEILPSAIGFWETFGLEPLQGEKDIIPFCIYPPNVIEAAEAFIERLGLVYSSGNFGSHSRSNKANGLVPWSLNAASDQNYASLMHALNVSCENLGSSLSNLSVTDKNVVIYIINPFIYDAAIVDICSAFLRLFHKYVGDIDRQHTRHLSELVLQIIPLEFIASADSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCSPPLVLADPAPKVVPFRLAAESVAPLEEAKSLHVAYSQSVDQRWVTAAWTDNSGRHQSALSYCLRERDSSVSRPISEIRTQIWATSKDIMDMSLSHWRLIVVKDEPVDLEEVEMWTSLLDQYNRTKAIKVELGIISVNTKPGLSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTYTDQHTPPQHAQQPSPDSDQDTILIDKSDETWGVTLSHRLNNSYYLTKHQPALASGYLFRRSGVSDTDGQAIMAVNIIYTNSRRPIDHILKDILRMYRELITLARVRGIVHAQGNSPLPWHIMTAIKGQEMLCYTL
Length1527
PositionKinase
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.08
Grand average of hydropathy-0.375
Instability index51.53
Isoelectric point5.23
Molecular weight168929.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     297.49|      91|     288|     557|     694|       1
---------------------------------------------------------------------------
  580-  681 (142.96/130.45)	FTGLTGDLDMQTSE..PEAVQHDTEANFTApdSADtamSITEPSPSNYdqnhltRSEHDTIKQPAFSSLITTGDEDHICKETTEL........SQIISTDDSQKKRPISPPL
 1130- 1199 (98.82/43.12)	FHKYVGDIDRQHTRhlSELVLQIIPLEFIA..SAD...SLVVPTQTDY.....................................lrlalevySRCPPKDRSSDWLGCSPPL
 1225- 1271 (55.72/15.34)	......................................................KSLHVAYSQSVDQRWVTAAWTDNSGRHQSAL........SYCLRERDSSVSRPIS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.83|      21|      66|     765|     785|       2
---------------------------------------------------------------------------
  765-  785 (39.33/21.40)	PEKGRKVR......PKPLPILTSLHPL
  828-  854 (32.49/16.42)	PKRNRDYEvegnstPSPLDILTQTSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.07|      25|     288|     121|     153|       3
---------------------------------------------------------------------------
  121-  153 (35.26/33.75)	KHCLLSDPDssifESAATQNKlttnCSEYAQLK
  420-  444 (46.81/24.49)	KHKTSDDPS....ELEKQQQK....CSEPSPLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      14|      15|     971|     984|       4
---------------------------------------------------------------------------
  971-  984 (25.35/15.28)	PSIRPNLTGSICKI
  987- 1000 (25.45/15.37)	PHIKVHRGNSYLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.33|      14|      16|    1044|    1059|       8
---------------------------------------------------------------------------
 1044- 1059 (21.40/18.99)	GLVYSSGNfgSHSRSN
 1063- 1076 (26.92/15.62)	GLVPWSLN..AASDQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25982 with Med13 domain of Kingdom Fungi
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