<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25980
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MDGTSANGPGREIERQHVDDTLSTTASLAPYNNGNHSNGPSHAKDAACPSNPKFDDFLPPELVHITQGFFPLGHLINRATQQCWNDLTDLITELANPQSTATHAAAGPVTTTNGKYTLSPSSAENAQKKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLATGRVAAIQERSFVPPKPLTPKEMLKTLKKINKTIRTRLVLHDQIPRAFTNYVVHDGRVTFKVPAEFEVDLSIAQESHSSQFFFVDIRFLFSPSPPKPAGRLLDELDNRVNAILMHSGLTGCYNLLHNLILSNKITILFHQAVELAREHWLDTLRVEVLHRTLVVQYWINRPGPKSWIEIGVKGGRRKEQTHDGSITESPFLGLRWMRDNKEVESKDIKLDPELLSMETILRSVTALHISFWLQSTYTKLSQGRLYASGALSVGLQTSINEPGNCFLDVQLTKGRSLRVMIEPVSGAIIFRPTPLLLNRYDIDRSFERPIIDDILFRISRLRSTAVIEEVESLATALGWETVNSRDIKNEDLRRIFPSNILRSVLFFRKSWECNYGIAYTCSMDGDNWWVVELRAPSRDKGPFSPQSARMVTGRFGGLPERLNYASFSQLDYALSGMLAIHVNACYLSELHGIHYFPSVRNLSLGPHLQVPSIFIRFRSGSLPSALRISPSITADKNPTVRDTVRLSFRGIHPSSQCAILLAHGNLSREIKDLALLAVHLDPTITFQPNGRGFAMRFLTPVGKPMIIQLLARLQQLEHVISTLDTLKQKSLKLLSVSLSKIKFSYAADEGARAIINFNYHEQSIESDIDSVTLLSKQAPLMLLRMSIDFHQQNPHRRVKESLTSTLNGLRPGARAGAGLEAVLKLLVITRPILQALERISTGSRSNLPGNSGVQITTRSSKIFHLRYPSLRYRFCIHAGLRRDRVVWVLRDMTTMSDKTGREAVELKLKEQIFGASGDGWQGLGNGAIADCEKIGNLVSALHGVLTDYISSETGGGLGMNPLGKRNGGTGTDLDPGSGGSSGGSDDVGL |
Length | 1066 |
Position | Tail |
Organism | Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.190 |
Instability index | 44.85 |
Isoelectric point | 9.36 |
Molecular weight | 118440.43 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25980
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 189.12| 53| 155| 175| 229| 1
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83- 127 (68.30/51.09) CWND..LT.......DLI.TELANPQ.STATHA.AAGPVTTTNgKYTLSPSSAENAQ
132- 169 (39.01/25.05) .....ILEFAQAKRaDFIKILVLSQWSRRAADV...SRLIDIQ...AFI........
175- 229 (81.81/73.32) CYNGaILSIGEMKR.DLIRAQTANPDLAMALEVlATGRVAAIQ.ERSFVPPKPLTPK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 117.49| 37| 47| 779| 815| 4
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779- 815 (59.46/43.22) GKPMIIQLLARLQQLEHVISTLDTL.KQKSLKLLSVSL
827- 864 (58.03/42.00) GARAIINFNYHEQSIESDIDSVTLLsKQAPLMLLRMSI
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