<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25974

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEESFPLPLRPLIEKSATEPDSLPIRIAQINGQRGSFRNVTETSLQEEIHAERARNAAGVEGEEEEEEAVESQEAKSADRLEQLFKSRAEIVDFVTQAHAEANYALDLVSLLVSRYTPRQAEMSMSPYLKQRAPLGSLGIDIIKTPEQTEAVQKEIADLSRGWKMENFDSAANKLLQSASRLEEEVTAETKYWAGVLNIKEKGWKVCRLPRERQTLGVQYGFLEATPTFRDRGLAALRRGNRGDLILDRGLQARKPRSLRVRVQHAGRIVGASKIVPLELAPGNDAIENHIRLTRDALYEEELFHELNREAPPLYCTCIESKENLIQLQLTLSTNSNRYDKQGHAEDALAETVAQSLRILLSHAHRQKYRCRTQMPPPVTSKRRANPEYSLLRPIVCYLQHKSALEWLKLSLSNITRTLQLAGLNCKYNISPLVSVKFPLVDASNPSPWELDTPPFVERLVNSFLTPFESIVTGTFLSPASSFKILIVTNISPSAFGTEFEIGSNISSSPRTKSSSSRFGLRDDLQQLLLHLFTTDLVYLIPNLARDAGTEPSSLRPNTSLLKQEQGQEQEQPEQSGFNTPTPRHTSHLTSWIPTSPENGELTVFSPSQRRHKKLTIDLHPDKLTVRCQWLRSEIDVDGNMDWEMSTGEGDVIYWWGDGGGNEGMTLQSIVGLMSQEAVKAEL
Length683
PositionHead
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.06
Grand average of hydropathy-0.480
Instability index58.60
Isoelectric point5.84
Molecular weight76724.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25974
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.65|      12|      15|     231|     242|       1
---------------------------------------------------------------------------
  231-  242 (22.17/13.55)	DRGLAALR.RGNR
  248-  260 (17.48/ 9.20)	DRGLQARKpRSLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.76|      14|      15|     429|     442|       2
---------------------------------------------------------------------------
  429-  442 (24.21/13.63)	NISPLVSVKFPLVD
  445-  458 (28.56/17.32)	NPSPWELDTPPFVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.33|      14|      16|      33|      48|       3
---------------------------------------------------------------------------
   33-   48 (18.55/16.40)	QRGsfRNVTETSLQEE
   52-   65 (22.78/12.58)	ERA..RNAAGVEGEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.60|      20|     183|     386|     414|       5
---------------------------------------------------------------------------
  313-  333 (31.89/11.81)	PLYCtCIESKENLIQLQLTLS
  394-  413 (36.71/17.23)	PIVC.YLQHKSALEWLKLSLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25974 with Med17 domain of Kingdom Fungi
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