<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25971

Description Serine/threonine protein kinase
SequenceMVSTGTMTTPSPRLRPLDSPPFSQRSKSRLPNSLEKRHSAQQFESENEKTPSGRDVYISRGAFFKRESKQNASFEDLPRSPVSSRPSLEGSRPSALDTSDPTARSKSANSKSRPASSFIGSRSERFRDFDSPRDSLDSSFPRGGYDGSDVLHHPRLETDRDHERANISSDIDFLRAKEVEESNRKREKRVSSGSKHMKRSSLTSISLSGTKNLLAGRFGDAFRRFENNAAQERTSRSPSPDNVNARLTPITGSEVTEMSDDGCEVNDGDISPEMRRELERRRLSLEERRVANAAAEYRQRLAERGEDGARGGGRIEGVRAASIQSKVQSLLKENDRHPTVKTASGYGRYTDTEAALQAKQFEQPSIPPRAVPFNVPRKPVSIQQQATEQAPRPQPKDPRSAGPLTMPIRSQQPTPSEQFVSRASTTAADQKPPAPPKPQNLRTGNRTENVVKEHNPPIEMAKKTSQNDDWEANFSKRYPSLSGLELVETEIDIPTPRVHAMRTKEACRPLMNVAFAPKDTSSSVASGFVPKALVSGGYTGTYQGNNLKFLLIVLGPETTLAVYPANVEASTNDLKDVIQHLFEIQSAVHGYLGSETQQELVRKIEKDKGKDALHTLHHRSTFENPRYINSSDNTRKSLTLSLSTLSEHSRPDPSASPSQTSLRINDPDPPLQSVQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKVQAFASFRDILAREMASAMPECKGEVERVLRVTGGSASS
Length750
PositionMiddle
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.05
Grand average of hydropathy-0.872
Instability index57.60
Isoelectric point9.27
Molecular weight83077.33
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25971
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     296.78|      82|      82|      25|     106|       1
---------------------------------------------------------------------------
   25-   77 (68.46/23.06)	.......................................................RSKSRLPNSLEKRHSAQQFE.SENEKTPSG.RDVYISR.GAFFKR.ESKQNASFEDL
   78-  140 (92.13/33.18)	PR.....SPVS.......SRPSLEGSR..PSALD..TSD.P.TA..RS...........................kSANSKSRPA.SSFIGSR.SERFRDfDSPRDSLDSSF
  141-  234 (90.55/32.50)	PRggydgSDVL.......HHPRLETDRdhERANI..SSDiD.FL..RAKeveesnRKREKRVSSGSKHMKRSSLT.S...ISLSGtKNLLAGRfGDAFRR..FENNAAQERT
  376-  433 (45.64/13.31)	PR.....KPVSiqqqateQAP.....R..PQPKDprSAG.PlTMpiRSQ...........QPTPSEQFVSRASTT.AADQKPP.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.04|      45|     219|     434|     488|       2
---------------------------------------------------------------------------
  434-  488 (67.38/51.51)	APPKPQNLRtgnrtenvVKEHNPPIEMAKKTSQNDDWEAnfSKRYPSLSGLELVE
  655-  699 (78.66/39.99)	ASPSQTSLR........INDPDPPLQSVQLPPEIIDYVD..AARNPDIYTREFVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.47|      40|     259|     323|     364|       3
---------------------------------------------------------------------------
  323-  364 (63.00/53.49)	IQSKVQSLLKENDRHPTV.KTASGYGRytDTEAALQAKQ.FEQP
  584-  625 (60.48/43.62)	IQSAVHGYLGSETQQELVrKIEKDKGK..DALHTLHHRStFENP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25971 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSPRDSLDSSFPRGGYDGSDVLHHPRLETDRDHERANISSDIDFLRAKEVEESNRKREKRVSSGSKHMKRSSLTSIS
2) LTLSLSTLSEHSRPDPSASPSQTSLRINDPDPPLQSVQLPPEI
3) MVSTGTMTTPSPRLRPLDSPPFSQRSKSRLPNSLEKRHSAQQFESENEKTPSGRDVYISRGA
4) RFENNAAQERTSRSPSPDNVNARLTPITGSEVTEMSDDGCEVNDGDISPEMRRELERRRLSLEERRVANAAAEYRQRLAERGEDGARGGGRIEGVRAASIQSKVQSLLKENDRHPTVKTASGYGRYTDTEAALQAKQFEQPSIPPRAVPFNVPRKPVSIQQQATEQAPRPQPKDPRSAGPLTMPIRSQQPTPSEQFVSRASTTAADQKPPAPPKPQNLRTGNRTENVVKEHNPPIEMAKKTSQNDDWEANFS
5) SKQNASFEDLPRSPVSSRPSLEGSRPSALDTSDPTARSKSANSKSRPASSFIGSRSE
130
638
1
224
68
206
680
62
475
124










Molecular Recognition Features






MoRF SequenceStartStop




1) GRDVYISRGAFFKRES
53
68