<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25967

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPFEPDASAASEKSSKAEQKDALNSIVLSAYLHLQSEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLPGCHSSVSEKAQPAVNKLRVASNGLWVAPGNSEEVAAALSQALRNSLERSLKGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVLISARYVRNLCSDDIEKVLTHSPPSIGEGLPVVVAPSGMLGRLVGCCPSDLVRQVYSSKSSAPNLPGFSQPTVCQLRGQSYYVEVALGFPAASADKVSESEHIQIKKELDPVKDAQVGADGQRKVESPDSLPVFERTFIYPPEAILVPMVHQAFVRFSSKRMCLQGSLGSSSWEGWPFWNFSPSSYFQNSSFLGSSCGLGVNSNYLRLRRKKNKCNSMASSISSVSSTSDGSDRAVATEGDLVADADSMPGRQSDMPSNNDNGGSKMVSKRPRSEVREVSSHTGQDVCENIQGVNGQVGRSWGWDDEGIVMDINILLSEFGDFSDFFQEEELDFGEPPGTAESHALVIPASDGGDVTFTDSPSTAMDIPEQRLSPVGFTSLDAFDHQIMVPAQDVVSKVQEPHKDSATPAQSHSLVLSSGRFDYITKAEAKLTFAPEYAAVEISIAEAPTPLFTNPYFPRSKKPGSSSFRVYSYDIAQSSQIESTGDKPDKPSKLTSGIHLHDVGSSNLYTLVQGGKKESDKSLKSTDIQPSKGETSPPISGVTSFSSSLVSQKKSDSTFNAGYFLLSMKTALATEIECIMFQAAMCRIRHTLLSLRSKASAEFNSATSSFMQTNFCNKSDLTPKYDMRKKEIMTVRLSSDVDHEMFDRSLMDNVGVWRPVVTPKGPKSLESLSANTLAGASPSLSIQRQPVVDLLCAMALLVQQSTSFVDMSLDMDDGDGSFFWLSLDEQKRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMISLLQSDIRQALKAAFANMDGPLSVIDWCRGRGNAAESVTADAYSFQYSTGDTLEPSSSLPIGGDSLSPPQPASSNRGISELEYQKGYHRIRPTIAVLPSPSMLVGYQDDWLKASVNSLKTWEKAPFEPYALPKPVTYYALCPDIDMLTSAAADFFMQLGTVYEVCKLGTHSPQNSGGQMELSSGKYLPSGLVLVECPEQLKKVGCGHLSPITSTSDYLQVFSKHWSVKSFVTSISRILKDIKLTSNISTNQKESSSGPCTVIYVVCPFPEPCAILQTLVECSVALGYVISSPERERKSLYSQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTIETVLRIDKPNKELAVLKDIAFTVYNKARRIPRAVSTSDMFQSPTYLGRSQSTMMHVTSPAPTLWKECLVPRMSGPTLSRETDFDASMRSATWDNSWQPARSGGLLDPSKMPDLCAQDDRKYAFEPLFILADPGSADLNALMEPSKSGADAGGSRVYGSMSGSNSDSGVSPLLDVSESDSAASLHCCYGWTEDWRWLVCIWTDARGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNMRPRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPEGIPPSSNGPTLQQQDMALIQDRNMPSSPNPLYSPHSKSSFMKGALGQSGNKKQILVEQTGMDTSRGPLHLVRSISLVAVSQDHSLHLTCQTDLLTRPASGEGNQGSSGLSSYLEGFTPVKSIGSMPASHSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTAIPLAMGYVVSKAVPPVRRDSAQLTKDEQPSVLLVSIIDHYGGSIATVQEKMSRGGGGSNMSKQARNFTQETTTRDCEVEMHNVLEAVATELHSLSWLTVSPVYTERRTALPFHCDMVLRMRRLLHYADKYLSQPAEKGETT
Length1912
PositionKinase
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.08
Grand average of hydropathy-0.261
Instability index56.23
Isoelectric point5.70
Molecular weight208149.86
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25967
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1076.35|     322|     506|     892|    1234|       1
---------------------------------------------------------------------------
  894- 1067 (216.67/116.31)	....................................................................................................................................................................................................TSFVDmsLDMDDGDGSFFWLSLDE......QKRRGF...SCDPSMVHAGCGGLLGTCHSK.........DCAGV.DLVDPLSA.E..VSESSMISLLQSDIRQA..LKAAFANMDGPLSvIDWCRGRGNAAESVTAD.AYSFQYSTGDTLEPS.SSLPIGGDSLSPPQPASSN.RGISELEYQKGYHRIRPTI...AVLP...SPSM
 1070- 1381 (403.12/240.72)	GYQDDwLKASVNSlKTWEKA..PFEPYALPKPVTYYALCPDIDMLTSAAADFFM......QLGTVYEVCKLGTHSPQNS.GGQMELSSGKYLPSGLVLVECPEQLKKVGCGHlspiTSTSDYlqvfskHWSVKSFVTSISRILKDIKLT.SNISTNQ..KESSSGPCTVIYVVCP.........................................................fpePCAILQTLVECSVALGYVISSpererkslySQVAK.ALNSSASAdE..ASASNVVMLSGFSIPK...LVLQIVTIETVLR.ID....KPNKELAVLKDiAFTV.YNKARRIPRA.VST...SDMFQ..SPTYLG.RSQSTMMH...VTSPAPTLwkeCLVPrmsGPTL
 1382- 1740 (456.55/238.45)	SRETD.FDASMRS.ATWDNSwqPARSGGLLDPSKMPDLCAQDDRKYAFEPLFILadpgsaDLNALMEPSKSGADAGGSRvYGSMSGSNSDSGVSPLLDVSESDSAASLHCCY....GWTEDW......RWLVCIWTDARGELLDSLIFPfGGISSRQdtKVLQSLFIQILQQGCQimssspeasnmrprdviitriGGFLE..LEIQEWQKAIYSFGGNEvkkwpvQLRRSI......PEGIPPSSNG..PTLQQQ.........DMALIqDRNMPSSP.NplYSPHSKSSFMKGALGQSgnKKQILVEQTG....MDTSRGPLHLVRSISLV.AVSQDHSLHLTCQTDlLTRPASGEGNQGSSGLSSYlEGFTPVK.SIGSMPASHSY...LLVP...SPSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.31|      28|     315|      94|     121|       2
---------------------------------------------------------------------------
   86-  114 (42.35/24.66)	WLFLPGChSSVSEKAQPAVNKLRVASNGL
  115-  143 (39.96/22.82)	WVAPGNSeEVAAALSQALRNSLERSLKGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.76|      27|     313|     210|     241|       3
---------------------------------------------------------------------------
  211-  237 (50.38/33.88)	PSIGEGLPVVVAPSGMLGRLVGCCPSD
  718-  744 (46.38/17.43)	PSKGETSPPISGVTSFSSSLVSQKKSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.24|      22|      22|     341|     362|       4
---------------------------------------------------------------------------
  341-  362 (42.45/24.58)	FVRFSSKRMCLQGS.LGSSSWEG
  365-  387 (39.79/22.49)	FWNFSPSSYFQNSSfLGSSCGLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25967 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DRAVATEGDLVADADSMPGRQSDMPSNNDNGGSKMVSKRPRSEVREVSSHTGQDVCENIQ
2) IPEGIPPSSNGPTLQQQDMALIQDRNMPSSPNPLYSPHSKSSFMKGA
3) QEEELDFGEPPGTAESHALVIPASDGGDVTFTDSPSTAMDIPEQR
420
1599
515
479
1645
559










Molecular Recognition Features






MoRF SequenceStartStop




NANANA