<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25955

Description RBR-type E3 ubiquitin transferase
SequenceMASGGGGGVGVCNKRYRRSDGDDDDGETSGRNKRCGVGPSSGPNDDGESGDFFDGWHAADDDGAGGGEDYMYGYDEDEDEADQSAEGDAADASASDDTEQRYVVLTESDVRARQEADTAKVAEVLSIPSGFAAVLLRHFKWRVGRVQEEWFTDERRVRAAVGLPAPEHGDELVPCTRSARAEVCGICFDPYPAGRTRSAGCGHYYCDGCWAGYVAAAVGDGPRCLSMRCPDPSCSAPVVRELVDKVLAAGAKERARYARFWLRSYVEESGGRIKWCGGAGCNRSVEVLGDAADAAAATDVFCDSGCRHGFCWACGEEAHRPVSCGTVRAWLAKNASDSETANWVVAHTKRCPKCRRPIEKNHGCNHMTCGAPCRHQFCWLCFDPWDNHRGCTRYDYRQRQQVEAAAADEEEARRRHAKESLERYLYHYERWAGNGKSLHKALADADELERSELERMARMVDVPAMELGFVTEAYRQIADGRRVLRWAHAYAYFLFLDPERDGAKRDLFDDLQSQANRWLECLHSCAELERKELFGGGANGDGEPSTVVAVEAFRAYKEKVANLTGVTRKFMGNLVKAFKTNLPEVVVTPAAFDFDHIVNGPTMGSQTAGVGGIISTATVTLEQPAMEPMVSGSAGFWHSALQQPSSSSLISQEANIANDSVQEHRPIRSPVQHPVRPGRHGGLLSNPSQFQPIHSTFFGEATTSMGPPNIGAITPLQFNMSNMISSGATSTPLVTFSMSAPGQPIGNQDMVQSTALGSFGSNTSTAWDNSDIAESSSQPNSMAMNRQAGINPLSSAMNAPIGMHHNAQQPPPKYVKIWEGTLSGQRQGRPVFISRLEGWSGIVSKTVAADWPETMQIVRLIAQEHMNNKQYVGKADFLIFRTLNQHGFLGQLQERKLCAVIQLPSQTLLLSMSDKAGRMIGMLFPENMVIFKPEVVTQPSLVRQEKLQQPQELLHHQQIQLQQQQKQQMQQMLHQRQHMRASTQNLPMQQQKLHQQQLQHQEQLHLQQQLIQHMQQQQPQYHQHLQQQIQHQQQLIQQIQQLRHQQQHMHQMQPQQQPLPQMVDTELGNDDDAREDWVTEPGQHA
Length1085
PositionUnknown
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.07
Grand average of hydropathy-0.606
Instability index56.31
Isoelectric point5.91
Molecular weight120462.34
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. 
ECO:0000256	ARBA:ARBA00003976
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
ubiquitin ligase complex	GO:0000151	IBA:GO_Central
GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-KW
ubiquitin conjugating enzyme binding	GO:0031624	IBA:GO_Central
ubiquitin protein ligase activity	GO:0061630	IBA:GO_Central
GO - Biological Process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	IBA:GO_Central
protein polyubiquitination	GO:0000209	IBA:GO_Central
ubiquitin-dependent protein catabolic process	GO:0006511	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25955
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     178.57|      29|      29|     995|    1023|       1
---------------------------------------------------------------------------
  939-  965 (42.86/18.89)	PSLVR...QEKLQQpQELLHHQQ..IQ.LQQQQ
  966-  990 (33.37/13.28)	...KQ..qMQQMLH.QRQ.HMRAS.TQNLPMQQ
  991- 1018 (42.77/18.84)	....QklhQQQLQH.QEQLHLQQQLIQHMQQQQ
 1019- 1041 (34.16/13.75)	PQYHQ.hlQQQIQH.Q......QQLIQQIQQ..
 1042- 1056 (25.42/ 8.58)	...........LRH.QQQ.HMHQ.....MQPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.54|      29|      34|      23|      51|       2
---------------------------------------------------------------------------
   27-   63 (47.66/24.13)	ETSGRNKRCGVGPSSGPNDDGES..GDffdgwhaaD...DDG
   64-   88 (34.23/15.21)	AGGGEDYMYGYDEDEDEADQSAE..GD...............
  268-  305 (31.65/13.50)	ESGGRIKWCG...GAGCN.RSVEvlGDaadaaaatDvfcDSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.56|      14|      21|     718|     736|       3
---------------------------------------------------------------------------
  714-  730 (22.24/20.78)	TPL.qfnMS.........NMISSGA.......TS
  731-  764 ( 7.32/ 7.18)	TPLvtfsMSapgqpignqDMVQSTAlgsfgsnTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.67|      14|      24|     187|     209|       4
---------------------------------------------------------------------------
  187-  204 (29.10/23.83)	CFDPYPAGRtrsaGCGHY
  381-  394 (32.57/ 8.61)	CFDPWDNHR....GCTRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.71|      17|      24|     601|     617|       5
---------------------------------------------------------------------------
  611-  633 (20.69/11.35)	GGIISTA..tvtleqPAMEP...MVSGS
  634-  656 (16.59/ 7.34)	AGFWHSA.....lqqPSSSSlisQEANI
  681-  705 (18.43/ 9.14)	GGLLSNPsqfqpihsTFFGE...ATTSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.90|      19|      24|     316|     334|       6
---------------------------------------------------------------------------
  316-  334 (35.44/24.04)	EEAHRPVS....CGTVRAWLAKN
  339-  361 (31.46/20.41)	ETANWVVAhtkrCPKCRRPIEKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.51|      18|      19|     775|     792|       7
---------------------------------------------------------------------------
  775-  792 (32.27/17.16)	SSSQPNSMAMNRQAGINP
  794-  811 (34.24/18.63)	SSAMNAPIGMHHNAQQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      13|      23|     206|     218|      13
---------------------------------------------------------------------------
  206-  218 (27.23/16.57)	C.D.GCWAGYVAAAV
  229-  243 (16.21/ 6.73)	CpDpSCSAPVVRELV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25955 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGGEDYMYGYDEDEDEADQSAEGDAADASASDDTEQRYVVLTESD
2) GVGVCNKRYRRSDGDDDDGETSGRNKRCGVGPSSGPNDDGESGDFFDGWHAAD
3) QKQQMQQMLHQRQHMRASTQNLPMQQQKLHQQQLQ
4) QQIQQLRHQQQHMHQMQPQQQPLPQMVDTELGNDDDAREDWVTEPGQHA
5) SLISQEANIANDSVQEHRPIRSPVQHPVRPGRHGGLLSNPSQFQP
6) STPLVTFSMSAPGQPIGNQDMVQSTALGSFGSNTSTAWDNSDIAESSSQPNSMAMNRQAG
64
8
965
1037
648
730
109
60
999
1085
692
789










Molecular Recognition Features






MoRF SequenceStartStop




1) MASGGGGGVGVCNKRYRRSDGDDDDGETSGRNKRCGVGPSSGPNDDGESGDFFDGWHAADDDGAGGGEDYMYGYDED
1
77