<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25942

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEKDDVRVDLDKLPIKRLEAIDEIGNEHYPPDTSNEEQRLAAIRRIDFSWVIEKDAKKAKKAAEADTTQQVWPWQGLMESLQQAHHELSVVIDLIGTVEANDAVAVASTTKPKSQPNEILVDMAVSAATKLQRLRHLSRYFKQSARTMEQQFQKETRFYSSLIRLQQNWKVKRQRAVGSPGSEGFMFDLVDSSQLDTTTMPRLSPLSLIPIDQDSSGTLSVQIPQKSFRSLTLQFRGDIANNAERSAIKKKEGTLTNTTTEAEKDVLENGDVNKSIKHAHSILRDIHKSIFEEQVFDMVIRETFVQSQGINVTGMCEDFLQLAIGQECSLCLSLELSRQNSISETVGQEDHMDTDYTENLAVATVNGKESSNKDVRGFPNPKCLEIYLLHMFHENILRKLREKSRHMVRYQSSAQAAPDDCGLLSHFCMTVSHRIFSNKVHLELESVVSRVPYLHLCSLPTWHSRTSSWSLCLKVPQPILATDRVRKPSDHHKLKYKSRSQFSTKVILKDGQISLMGEGSPSIAGSLTGKPSDGRLINSYNCDLEDLPMMLLQQVASQVIHWLHDEAMVLGMNVTRDFLCLYFDLDQGETLGLVAHVDPDDTYGCISWYLTVDHPMEEGKMSADSPELEKRRFLGYLSLEVLYSTLMDLIKLCSTGVQH
Length659
PositionHead
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.06
Grand average of hydropathy-0.397
Instability index43.96
Isoelectric point5.93
Molecular weight74539.99
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
production of miRNAs involved in gene silencing by miRNA	GO:0035196	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.34|      18|      21|     191|     208|       1
---------------------------------------------------------------------------
  191-  208 (31.47/18.83)	DSSQLDTTTMPRLSPLSL
  214-  231 (30.87/18.34)	DSSGTLSVQIPQKSFRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.37|      53|     248|     298|     357|       3
---------------------------------------------------------------------------
  298-  357 (79.22/76.09)	MVIREtfVQSQGINVTGMCEDFLQLAIGQECsLCLSLELSRqnsiSETVGQEDHMDTDYT
  550-  602 (95.14/67.03)	MLLQQ..VASQVIHWLHDEAMVLGMNVTRDF.LCLYFDLDQ....GETLGLVAHVDPDDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.72|      34|     266|      95|     146|       4
---------------------------------------------------------------------------
  112-  146 (53.87/57.17)	PKSQPNEI.LVDM.AVSAATKL.QRLRHLSRYfKQSAR
  379-  415 (48.85/20.74)	PNPKCLEIyLLHMfHENILRKLrEKSRHMVRY.QSSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.19|      24|      25|     232|     255|       7
---------------------------------------------------------------------------
  232-  255 (38.11/30.56)	TLQFRGDIANNAE.RSAIKKKEGTL
  259-  283 (34.08/26.49)	TTEAEKDVLENGDvNKSIKHAHSIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25942 with Med17 domain of Kingdom Viridiplantae
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