<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25941

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGLGAGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLHSHETCFTQTADSLFYMHECLQQARAPMFDVPSAIEVMLTGGYQRLPRCIEEIGSQNKLSPDEEKCALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVFRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDQSRRFALGDDIERRMAASENPFAVLYAILHEFCISLAMDTIIRQANVLRQGRWKDAIRSELISDSATGQTGNTPLMQLVQDGEFDASGFKIPGLKVNYWLDEKSTGTTEPDSSPFIKIEAGLDMQIKCQHSSFILDPFTDKEANLSLDLSCIDVEQLILRAIACNRHTRLLNIQRQLCKNVQISQSPKDVVLTRDVAAAKDPTKNAEKKGFSDCFGNEVLQVRAYGQAYVSLGINIRSGRFLLQSPENILPRAAIMDCEEALNKGSTSATEVFSSLRTRSILHLFAASGSFFGLKVYQQSQGTLKIPKTILHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDANDKTNANGDAKEAIRFNKINIGQMQILKNETNANPFDMKLQALQSLVDPADMMESDLPVQNGIETLPLLPACSPSFSSIVDEVFEYERGSTAAQNHSLSVDIQGINARVVSPMHDGSLSHTQANNIAKIHPSGSLNSYFPSNFRYLQGVNKSLHLVPSSNNNSSQIPAQSSHSGNLGNAMPGHLVGSSTITGGLEKSITAGSDGASRKRSLSDFLPSIPSLRGLQASEPRKRRKKSESVQNILPLQAHSSNLQSRVSLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSNLWLRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELNGGSTTTQWGVGIRIANSSEMDSHISFDSNGVVLTYNTVEADSVQKLVSDLRRLSNARSFARGMRRLIGVKLDDKLDDNQLSMEVKSQSVNKGNSDAADKLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIDKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSSMPKQPNILTQGPLANGSSSSTIHHAPVPQNAAAAQLGSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASGHLNNNAGAPQTAPSANRLSATPGVSMSRPTSGVANHVAASLSRAGNAMLASSALASGISGASVRLTAGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGLSPVNGDIATAQRARIELCLENHSGSAAADNTENSTLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVKLRYSFGDNNHIAFLAMNGSHGGRACWLQFEEWERCKQKVSRAVETVNGSGVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1723
PositionTail
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.07
Grand average of hydropathy-0.173
Instability index48.66
Isoelectric point8.31
Molecular weight188272.78
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25941
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.20|      79|     115|    1126|    1216|       1
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 1126- 1213 (115.66/95.39)	IRLTAGPLLALGGAIRPARMPvTVsSGYSSMPK.QPNILTQgpLANGSSSstihHAPVPQNAAAAQlGSHNLHAAAMLSA..AGR..GGPGLV
 1244- 1327 (130.54/75.20)	MRCFAGDQVWLQPATPPKGGP.SV.GGSLPCPQfRPFIMEH..VAQGLNA....LEPNFMNATQAS.GHLNNNAGAPQTApsANRlsATPGVS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.37|      15|      15|     764|     778|       2
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  744-  772 (18.06/ 8.80)	HLVPSSnnnssqipaqsshsGNLGNAMPG
  773-  790 (19.32/10.07)	HLVGSS...........titGGLEKSITA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     254.82|      99|     115|     202|     308|       3
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  202-  269 (78.28/59.50)	...................................................DGEFKvllTLGYR..G.NVDLW.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................rilHMELLVGEKK.GPIKLDQSR..RFALG.DDIERRMAASE...NPFAVLYAILH
  270-  385 (121.76/84.98)	EF.CISLAmDTIIRQANVLRQGRWKDaIRSELISDSATGQtgntplmqlvqDGEFD...ASGFKipGlKVNYW.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDEKStGTTEPDSSPfiKIEAG.LDMQIKCQHSSfilDPFTDKEANLS
  387-  424 (29.22/10.65)	DLsCIDVE.QLILRAIACNRHTRLLN.IQRQLCKNVQISQ..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1565- 1604 (25.57/ 7.57)	.........................................................................spkdvvltrdvaaakdptknaekkgfsdcfgnevlqvraygqayvslginirsgrfllqspenilpraaimdceealnkgstsatevfsslrtrsilhlfaasgsffglkvyqqsqgtlkipktilhgsdlmvmgfphcanayyllmqldkdfrpvfhlletqcdandktnangdakeairfnkinigqmqilknetnanpfdmklqalqslvdpadmmesdlpvqngietlpllpacspsfssivdevfeyergstaaqnhslsvdiqginarvvspmhdgslshtqanniakihpsgslnsyfpsnfrylqgvnkslhlvpssnnnssqipaqsshsgnlgnampghlvgsstitggleksitagsdgasrkrslsdflpsipslrglqaseprkrrkksesvqnilplqahssnlqsrvsltygdvlaernncvpatiyasvllhvirhcslcikhaqltaqmdslaipyveevglrtpssnlwlrlpfaqddswkhiclrlgkagsmswdvrindphfrelwelnggstttqwgvgirianssemdshisfdsngvvltyntveadsvqklvsdlrrlsnarsfargmrrligvklddklddnqlsmevksqsvnkgnsdaadklseqmrktfrieavglmslwfsygtmpmvhivveweidkggctmhvspdqlwphtkfledfvnggevasfldcirltagpllalggairparmpvtvssgyssmpkqpniltqgplangsssstihhapvpqnaaaaqlgshnlhaaamlsaagrggpglvpssllpfdvsvvlrgpywiriiyrkkfsvdmrcfagdqvwlqpatppkggpsvggslpcpqfrpfimehvaqglnalepnfmnatqasghlnnnagapqtapsanrlsatpgvsmsrptsgvanhvaaslsragnamlassalasgisgasvrltagaglpvhmkgelntafiglgddggygggwvplaalkkvlrgilkylgvlwlfaqlpellkeilgsilkdnegallnldqeqpalrfyvggyvfavsvhrvqlllqvlsvkrfhhqqqqqqaqsnaqeelaaaeineicdyfsrrvasepydasrvasfitlltlpisvlreflklitwkkglspvngdiataqraRIELCLENHS.GSAAADNTE..NSTLAkSNIHHDRAHSS...VEFA.......
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.86|      45|      59|     450|     495|       4
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  450-  495 (72.76/55.66)	FSDCFGNEVLQVRAYGQAYVSLGINIRSgRFLLQSPENILPRAAIM
  512-  556 (75.10/52.20)	FSSLRTRSILHLFAASGSFFGLKVYQQS.QGTLKIPKTILHGSDLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.68|      47|     778|      78|     126|       6
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   78-  126 (85.62/59.84)	VLAKWCQQVPLVHYCQQLGSTLHSHETC.....FTQTADSLF..YMHEClqQARAP
  853-  906 (72.06/44.27)	VLAERNNCVPATIYASVLLHVIRHCSLCikhaqLTAQMDSLAipYVEEV..GLRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.56|      36|      60|     637|     676|       7
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  637-  676 (53.95/44.60)	VDPadMMESDLPVQNGIETLPLLPacSPSFSSIVDEVFEY
  700-  735 (65.62/40.12)	VSP..MHDGSLSHTQANNIAKIHP..SGSLNSYFPSNFRY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.08|      25|      28|     991|    1015|       8
---------------------------------------------------------------------------
  978- 1007 (20.03/ 9.15)	...SFdSNGvvltyntVE.ADSVQKLVSDLRRLS
 1008- 1034 (29.68/17.34)	NARSF.ARG.mrrligVK.LD..DKL..DDNQLS
 1038- 1059 (24.36/12.82)	KSQSV.NKG.........nSDAADKLSEQMRK..
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.81|      15|      22|    1398|    1413|       9
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 1398- 1413 (22.99/21.09)	W....VPlAALKKVLRGILK
 1419- 1437 (21.82/13.75)	WlfaqLP.ELLKEILGSILK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.60|      10|     115|     811|     848|      11
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  797-  806 (18.89/13.42)	RKR.....SLSDFLP
  820-  834 (12.70/22.92)	RKRrkkseSVQNILP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25941 with Med14 domain of Kingdom Viridiplantae
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