<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25926

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEKEVVNKHLLDITRTSDLISWSRNGSIAYIPPTSTSNTNLLLTYIENVNGVTWQLAKPLPINIKIDNSNNFLPQLSLVSWSTLSTDLAICDIYGNFYILLAGVRLLESKDVMSPSFELTSFNHMEMIYRDIINNDINSPVNPGASVIAYKWLNIEKPQIWNKPATRVNLDYPNSDGNSFMYAYGVNQYQPHGVCHPIATKQAILVLRKNGQLMLYYQGEHKVEYHKISHNLTEEFQIVDKAGIGFTNDKQVIITTWDSVTNNISTYSVEINWGFLTESAKRQKVDAHYHTPKESQKPPKLTVKKIHQMKPQEFYHEGEEQYGQSFNVTELSSIDIISANPDSNSKLSILITYDSSVIYRYSLDHAVVSDVFTGLGLQKNVQWQGRESRTITLRDRLIRSGEIESVTAGFLDYTFSILYKDGTIEVIDTRTLKIQNKITEDTKPSQISSIFDIGFEVPKLDHTKPLIMAVSPNSAAVVYTEVFADSPNLKLKPFERTRNLGNEQGELYTTAVGFAYCHALALYSSTGSDDLIILIQSEAERLRKLIGDNDNKDLELEIRKFIGIVITECHKAINFQIDGYSKDGIEKLLSSNNASLHKLLSLHFILGEVQQNHQASDINMIILHLRSTSLGIMFSLSNIYRQISKKKPSEDSLQDSINRGECIISLLGSFKWLIDLLAYLNQELLQLTYMKNSNLSNSKLTLKNSLAIPIIMGKVPRLFLVYAITSMGRTHEILKKLHKDLTDSNKLFTPMKESLNRYFSIYNTAPITVNLFENFLRECDALCTKELSAKFKNKEHALRCEQKLVCQGELPDEFIEVAQILLDRFTLTSSREIKVAELISYPTEWLDIGVMRNRLRVDPRQIINETPGKIIPRWSLDSEHIDALRKTFIYDEGEDLKGLRQCTRCRAISSVTDISIFDAPLHVGLWTMLFQRNCNCGNPWITNL
Length944
PositionTail
OrganismCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.241
Instability index39.34
Isoelectric point6.42
Molecular weight107434.66
Publications
PubMed=19465905

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25926
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.93|      55|     152|     702|     783|       1
---------------------------------------------------------------------------
  596-  659 (82.11/40.29)	LHKLLSLHFILGEVQQnhqasdinmIILHLRSTSLGIMFS.LSNIYRQISKKKPSEDSLQDSINR
  702-  757 (86.82/95.16)	LKNSLAIPIIMGKVPR.........LFLVYAITSMGRTHEiLKKLHKDLTDSNKLFTPMKESLNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.68|      21|     152|     760|     783|       2
---------------------------------------------------------------------------
  760-  783 (32.41/26.09)	SIYNtAPITVNLFEN.FLRECDalC
  915-  936 (40.26/21.88)	SIFD.APLHVGLWTMlFQRNCN..C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.43|      30|     208|     121|     151|       3
---------------------------------------------------------------------------
  121-  151 (53.55/40.34)	SFNHMEMIYRDII..NNDINSP....VNPGASVIaYK
  325-  360 (43.87/27.73)	SFNVTELSSIDIIsaNPDSNSKlsilITYDSSVI.YR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.58|      74|     106|     362|     443|       4
---------------------------------------------------------------------------
  362-  443 (106.72/82.38)	SLDHAVV..SDVFTGlglQKNVQWQGREsRTITLRDrliRSGEIESVTAGFlDYTFSI.LY....KDGTIEVIDTRTLKIQNKITE.DTK
  471-  552 (106.85/61.59)	SPNSAAVvyTEVFAD...SPNLKLKPFE.RTRNLGN...EQGELYTTAVGF.AYCHALaLYsstgSDDLIILIQSEAERLRKLIGDnDNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     311.05|      98|     573|     220|     323|       5
---------------------------------------------------------------------------
  220-  323 (157.14/136.91)	EH..KVEYHKISH.NLTEEFqiVDKAGIGFtnDKQVIITTWDSVTNNISTYSVEinWGFLTESAKRQKVDAHY...HTPKESQKPPKLTVKKIHQMKPQEFYHEGEEQYG
  795-  898 (153.90/114.35)	EHalRCEQKLVCQgELPDEF..IEVAQILL..DRFTLTSSREIKVAELISYPTE..WLDIGVMRNRLRVDPRQiinETPGKIIPRWSLDSEHIDALRKTFIYDEGEDLKG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25926 with Med16 domain of Kingdom Fungi
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