<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25912

Description Meiotic mRNA stability protein kinase UME5
SequenceMNYSTSSGGPGGQYRNLNNVPIQQYHPQQQHQQSQQNFQHIMQQHHHHHQQLQQNQGQLPMRSTMPHHQLSRGTSGTSGIMGGVGGGPMPTSSNTSRTNSIPQPALMASNSILTLGPFKHRKDLTRESVLSTYQIMGYIAAGTYGKVYKAKLKNDKPNGNISNNITEDNGNDMLDESIVSPQINLGNGNSNFNNNNNNSNNNHNHNNNNGALPQFYAIKKFKSDNHHHHGNNNGRAGGNNSNNNTVNNLNKNQNQNNQNSIHQDEVLHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMIFEFCEHDLLQIIHYQSHPEFKPIPNSTVKSLIWQILNGVTFLHKNWIFHRDLKPANIMVTSQGVVKIGDLGLARKFKDPLQSLYTGDKVVVTIWYRAPELLLGTRHYTPALDLWAIGCILGEILSLRPMFKGEECKIDLNNKKSVPFQKNQLQKIIEILGTPTTDIWPSLNKYPEYLSFTQNFNQNYMNNLSNWFKMINSGNNNTNNGSSTGNNNSTANCLDLLAGLLKYDPEQRLTADQALLHPYFLELPKVTENAFEGLTYKFPNRKIYTDDNDIVTGGCGGGNANNHHQQQQQQQQQGQQQQGQQSQSGGPIQIQQVQQLQQQIQSQQLQGYKRSGMDDLSGGIRKKRG
Length659
PositionKinase
OrganismCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.07
Grand average of hydropathy-0.827
Instability index45.26
Isoelectric point9.16
Molecular weight74144.79
Publications
PubMed=19465905

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25912
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.34|      16|      16|      35|      50|       1
---------------------------------------------------------------------------
   36-   53 (29.26/12.43)	QNFQHIMQQHHHHHQ.....qlQ
  603-  625 (21.45/ 7.03)	QQQQQGQQQQGQQSQsggpiqiQ
  626-  640 (23.64/ 8.54)	QVQQL.QQQIQSQQL.......Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.97|      25|      47|     163|     209|       2
---------------------------------------------------------------------------
  163-  209 (39.96/38.37)	NNItedngndmldesivspqinlgnGNSNFNNNN.NNSNNNHNHNNNN
  234-  259 (41.01/13.26)	GRA......................GGNNSNNNTvNNLNKNQNQNNQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.10|      16|      16|     478|     493|       3
---------------------------------------------------------------------------
  478-  493 (28.94/13.91)	NKYPEYLSFTQNFNQN
  496-  511 (29.16/14.06)	NNLSNWFKMINSGNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.95|      23|      26|      65|      89|       4
---------------------------------------------------------------------------
   65-   87 (42.66/31.87)	MPHHQLSRGTS.GTSGIMGGVGGG
  119-  142 (33.29/16.01)	KHRKDLTRESVlSTYQIMGYIAAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25912 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNDIVTGGCGGGNANNHHQQQQQQQQQGQQQQGQQSQSGGPIQIQQV
2) MNYSTSSGGPGGQYRNLNNVPIQQYHPQQQHQQSQQNFQHIMQQHHHHHQQLQQNQGQLPMRSTMPHHQLSRGTSGTSGIMGGVGGGPMPTSSNTSRTNSIPQPALMASNSILTLGPFKHR
3) VYKAKLKNDKPNGNISNNITEDNGNDMLDESIVSPQINLGNGNSNFNNNNNNSNNNHNHNNNNGALPQFYAIKKFKSDNHHHHGNNNGRAGGNNSNNNTVNNLNKNQNQNNQNSIHQDE
581
1
147
627
121
265










Molecular Recognition Features






MoRF SequenceStartStop




1) DDLSGGIRKKRG
2) LQGYKRS
3) SGGPIQIQQVQQLQQQI
648
639
618
659
645
634