<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25911

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAEANAASISTHYYKLAHLGSINYTIYESAANNDQALLELELTIRHQFPEILITYYNKNLYYFTFGHNVESIIDLVKEFPQLSIKQSDTATSEQFANPLKVPNEYLTYAGLSFLKAIKKMILYNLSLQGLVKLFGNYCVISNKDQSYSILCLDPVLFQNGDLLLSCLEKPSVRLFDSSLAYPQDCSIETNYVIYLVPSGIRCHLFDATNLRNNLVEKPQVENEKLLELLRLTTGIDCSKSSLWVKLIPNLKHLNHQTSFIGKFIHSVDNKKFILWPWELCLLQFGKFENLKQEIISDTPDINNPLNLIADFLDFQITHNTHLQQQKMLAQAQQEQQQQQQEQQQQQVPQNNQSQSMTHPPLSVGSVHSNSGIGSVTEIPKDIDSIGLSATTPMDAEMFTLQNTEEFFKTDQANLNPGDDTNITEQKIEKSEDDDMEIDELFGGDDSDEERNEEKEDSKENSVKVDADDLDDLFADEKSESNVAVEEPQSEEVVKDQLPNIPSEEVENNKENLKPKEVKPSYIDILRDQMTIKKMDGSPDYKDPGAPLPIVPTPLVSSTITQSASATNPPTVGPFEGAYDNVSNSSAGVYGQSAPASQMPQQKSVFSPILFNPIIKSDIDTKYGKGGKFYVDKDSSKDIDFETKKRTLRATSVSGMEPSFNTEDKKKLQQQMEVIESSTTSSGSENGQDNEHEDEGDDEDEDDDDDDEDEEESDVDEEPDIGDLTPLKLNTYNESMVYQQNNNVASTNNIATGGQEFQNNGTEKQPFANSSLNAEGFGSPFASQINKFALKPDSPFSTNEIQSSMSPMYFDPPQSQQSPQLQPTVGNPDTTSKSAVLDSPSKISESSNYLPLLLRNINVATIPSLFLMNNLTSNKLLPSFTINDEDSENDLDITKSNEMIVKLEHLKDFLSFITPNIVYDLGSTSFDNFSYYVNNVKDLSDSVRELRLPPESFFNGLAKIFPFTYPVKLIELLHDVKSLEMEDPLDNQLNFLNEVDNEDESYADPKTLYKKLKSIEWDSFDVNNENKLKFEKYKEIIGKLNLGNSINDDDYFKLPVVKTRVLKNGNILNLNNVGLEFWKYLNFAPVKKQKNFQILLIAEANGSSSSYASEFLAQLVQNYKESNFGTISKVNLSTVETRADLDPISDGLVLISKDPNQSYNDFYIQTNKKLISLVELIKLDLINKTNNFEFDRPLLLFFVNFNESLNSDLQICKIFRNFKVALMSHQLPLVEIFTKIVPSSLIVKKVNHESTLKVFNNFKLTKISMNLYNECPNDLANKNIAKNIFTTVVKEPPSKIQFKFINNSYRDNGFNDDIFLHLAYERSIDKNWFVASWSDPLGQAVYTKSWYCSVPSGSVNDQSRSHHRNDTMDVMAITDDMWNCSTELFKFLNDEINSFGGNTFGGKKFLVLTRVNSIIPDDELIHWKRLSSKHKEISLIVLSVCQTPKIVSSSELKEVANKSSTSTSPMSMTQDKDSFFNFKTGFSMSNNSSPASGGALVMSPNGLSFHSPQQFLNAPANFLSPQDFTPGGTSSGGMEIDPDMILDRADSDIYGVVPRLPLPSFNSPTRFCMKTGYLMMNINDTADESDEDDTRKKSYILFEINILSCSNYWNLDVLMRLLMLQYKKMIALNNILCMESIDNPVEGSNYSDKTSQLVPWHINAVGKLLNYLVHIYVDEE
Length1675
PositionKinase
OrganismCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.480
Instability index47.88
Isoelectric point4.65
Molecular weight188983.49
Publications
PubMed=19465905

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25911
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.58|      42|      49|     138|     186|       1
---------------------------------------------------------------------------
  144-  186 (72.44/56.64)	DQSYsILCLDPV.....LFQNGDLLLSCLEKPSV...RLFD.SSLAYPQDCS
  188-  238 (57.13/28.61)	ETNY.VIYLVPSgirchLFDATNLRNNLVEKPQVeneKLLElLRLTTGIDCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.16|      45|      48|     987|    1032|       2
---------------------------------------------------------------------------
  907-  942 (46.27/21.89)	..DFL........SFITPNIVYD.LGSTSFDNFSyyVNNVKDLS.DSV
  987- 1032 (73.93/43.45)	QLNFLNEVdNEDESYADPKTLYKKLKSIEWDSFD..VNNENKLKFEKY
 1038- 1079 (69.96/36.88)	KLNLGNSI.NDDDYFKLPVVKTRVLKN..GNILN..LNNVG.LEFWKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     126.78|      21|      26|     452|     472|       3
---------------------------------------------------------------------------
  428-  449 (20.39/ 7.85)	EKSED........DDM..EIDelfgGDDSDEE
  452-  472 (33.82/18.67)	EEKEDS.....KENSV..KVD....ADDLDDL
  475-  500 (20.96/ 8.30)	DEKSESnvaveEPQSE..EVV....KDQLPNI
  689-  703 (24.34/11.03)	NEHED.......EGDD..E........DEDDD
  704-  726 (27.27/13.39)	DDDEDE.....EESDVdeEPD....IGDLTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.16|      27|     207|     347|     373|       4
---------------------------------------------------------------------------
  347-  373 (49.99/28.40)	VPQN......NQSQS.MTHPPLSVGSVH......SNSGIG
  550-  587 (33.29/16.34)	VPTPlvsstiTQSAS.ATNPP.TVGPFEgaydnvSNSSAG
  598-  625 (37.88/19.65)	MPQQ......KSVFSpILFNPIIKSDID......TKYGKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.38|      19|      42|    1205|    1226|       5
---------------------------------------------------------------------------
 1205- 1226 (28.87/31.18)	NSDLqicKIFRNFKVALMSHQL
 1248- 1266 (32.51/23.08)	ESTL...KVFNNFKLTKISMNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.69|      17|      53|    1230|    1246|       6
---------------------------------------------------------------------------
 1230- 1246 (28.94/19.52)	EIFTKIV...PSSLIVKKVN
 1282- 1301 (25.75/16.47)	NIFTTVVkepPSKIQFKFIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.60|      48|      53|     793|     845|       7
---------------------------------------------------------------------------
  745-  793 (49.60/25.44)	..STNNIAT..GGQEFQNNGTEKQPFANSSLnaegfGSPfaSQINKFA.......LKPDS
  794-  846 (73.17/54.71)	PFSTNEIQSSMSPMYFDPPQSQQSPQLQPTV.....GNP..DTTSKSAvLDspskISESS
  850-  895 (64.83/35.92)	PLLLRNINVATIPSLF.LMNNLTSNKLLPSF.....TIN..DEDSEND.LD....ITKS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.40|      60|    1159|     250|     315|      10
---------------------------------------------------------------------------
  250-  315 (94.71/74.87)	LKHLNhqtSFI..GKFIH....SVDNKKFILWPWELCllQFGKF...ENLKqEIISDTPDINNPLNLIAD...FLDFQ
 1407- 1478 (80.69/47.73)	LTRVN...SIIpdDELIHwkrlSSKHKEISLIVLSVC..QTPKIvssSELK.EVANKSSTSTSPMSMTQDkdsFFNFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.77|      23|    1093|       1|      24|      11
---------------------------------------------------------------------------
    1-   24 (37.71/32.18)	MAEANAASISTHYYKLAHLGSiNY
 1096- 1118 (40.06/28.77)	IAEANGSSSSYASEFLAQLVQ.NY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.78|      29|     268|     380|     411|      12
---------------------------------------------------------------------------
  380-  411 (48.14/44.32)	KDID....SIGLSATTPMDAE.MFtlqNTEEFFKTDQ
  636-  669 (39.64/27.33)	KDIDfetkKRTLRATSVSGMEpSF...NTEDKKKLQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25911 with Med13 domain of Kingdom Fungi
Unable to open file!