<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25910

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGFPPTSIPTNKKKESENPKPEKKKKKKHRIYFKLSYTFYKKHISMTEQVLSLSKLIEKAANQKLQPKLFISLFNQFSKRKQLQNSEYVNELLNIKPDNNSLKQRKWNEYQLNVVIELSFSSIENSHMFWSNLHQANDSFQCAYLLKLSRALVGVQHFDRDVLKNFISVEFMEYVHKYIQREKLSDKVLEHTVFLLSVIVQKFDKFIEEKTSGTVQDFIVKLIPFLRSVTGNENLSSMLLLKTKHILSKAQIDQLESTQHIRMERQGSIISLNPSIHANVASLTMINKLDEYYFRMRYIWIHKLFCHFNYNDTLNFFISNLVIASNQKNSYLIAYDFIKTVFTGMDMDGYCLFNAKNFILTRVPHLLNGLRYGEESLEKAVNDALQNLEIDDSFKQRFLKALEFPDEPVLQLRDKFNEKLLNINSEFTSLEESGLVELVNALPKLCQSHRTQQEVTQVILDIVDELGYSKDFEKLNRLLLTVMNNIELVNIVLFNSNLSLFYKLLDIIDNSNFRVDEDDENFQDQYSYCGIIMLSIVIIVQNFGVDLSKLTVKESFIINYLNDFYYRMCDNLSNVTPVNGDDEDRIIAENYHNLLNEWITALFDDRNEGLSDDLIKSLSIKQIYKLVPLIYKQGIIAADCNKIDWNILSNGLEYLSQPFLTPIVPIIIKFLVRDCNIDHELKLRIIKEMINDSSSLTVKMVISICGNDIIKLNPPAELKEQIQQCVHYSDTIDPFPRDYNVKDTFRSQLLGETRLSNKFVTTYVLGKRADVISSLVQEIYNFQKSNHEDSKMFINLMVFIILLDSVESRQDKDYWKREFSALSSTQLQKSSHTGFELTMDYHFSSIFNDSSSSIPLGQQQGQKLQVQDGMDGINDFLKGVTGGDDNDDDDAMMQDDDLFNEKPKTSDQLQNLLQKVHRYSCLINQFRKIRNESFNNSMFGKSVSLLNDKLMEEMNNWHF
Length959
PositionTail
OrganismCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.323
Instability index33.82
Isoelectric point5.84
Molecular weight111685.49
Publications
PubMed=19465905

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25910
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     441.87|     143|     189|      31|     193|       1
---------------------------------------------------------------------------
   31-  133 (124.21/71.93)	............................................................................................IYFKLSYTFYKKHISMTeqVLSLSKL.IEKAANQKLQPKLFISLFNQ.......FSKRKQLQNSEYVN....E.LLNIKPDNNSLKQRK.WNEyqlNVVIELSFSSIENshMFWSNL
  134-  321 (192.77/119.91)	HQANdSFQCAYLLkLSRALVGVQhFDRDVL...KNFIsvefMEYVHKYIQREKLSDKvlehtvfllsvivqkfdkfieektsgtvqdfivklIPFLRSVTGNENLSSML..LLKTKHI.LSKAQIDQLESTQHIRMERQ.......GSI.ISLNPSIHANvaslT.MIN.KLDEYYFRMRYiWIH...KLFCHFNYNDTLN..FFISNL
  326-  432 (124.89/58.94)	NQKN.SYLIAYDF.IKTVFTGMD.MDGYCLfnaKNFI....LTRVPHLLNGLRYGEE.............................................................sLEKAVNDALQNLEIDDSFKQrflkaleFPDEPVLQLRDKFN....EkLLNINSEFTSLEE..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.52|      27|      34|     618|     647|       2
---------------------------------------------------------------------------
  618-  647 (39.99/51.42)	LSIKQIYKLVPLIYKqgIIAADCNkIDWNI
  655-  681 (49.53/45.54)	LSQPFLTPIVPIIIK..FLVRDCN.IDHEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.08|      38|     188|     690|     752|       3
---------------------------------------------------------------------------
  713-  752 (66.14/67.19)	NPPAELKEQIQ...QCVH.YSDTIDPFPRDYNvkDTFRSQLLGE
  900-  941 (58.93/22.71)	NEKPKTSDQLQnllQKVHrYSCLINQFRKIRN..ESFNNSMFGK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25910 with Med5 domain of Kingdom Fungi
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