<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25908

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMHRYHRTDLQEALEVLEQPKPNQLPPTPQAVKMEESFPLPLRPFIQKSAREPDSLPIRIAQINSQRGSFRNVTEQSLQAEIDAQRARAAAGLEAEETEETESQEVKSTDRLEQLFKSRAEIVDFVAQAHAEANYALDLVSLLISKYTPRQAEISMSPYLKQKAPLGSLGIDIIKTPEKTESAQKEIVDLSRGWKLETFDFAANKLLQAASRLEQEVAAETKYWADVLSIKEKGWKICRIPRERQTLGVQCGFLEATPTLRDRGLAALRRGDGGDLILDRGLQPSQPRSLRVRVQQHDQIVGCSKLISLELAPGDDTIEHRIRLARDVLYEEELFHELNREARTLLQHGIQSKENLIQFQASDNQQILIDMVGLDAYNISDLNQQEHAEDALAEAVAQSLRLLLSHAHRKKYRRRARIPPPVTLKRRPNPEYSLIRPIVSYLQHKSALQWLRSFLSTITRTLQLAGLKCKHDVSPLIFVRLPPMNKTIPSPSEPDTLPFVERLVDTFLTPLESIVTGTFLSPTSNFKIRIVTNISPNGYGTEFEIATNMTSGSRTKSSSSRFGLRDDLQQLLLHRFTIDLVYLIPTLAWDTGTESSPPPISSQQKQEQGQAQVQTEQTHFNTPVQPRASHPTPWTPTSPENGELVASSPTQRRSKKLNIDLRPERLTIQCQWLGAGLDADLGEALESMARGGNVIYSWSDDGGGEEKTLQSIMGLLSQWETRPEL
Length724
PositionHead
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.507
Instability index53.75
Isoelectric point6.27
Molecular weight81560.51
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.52|      15|      15|      24|      38|       1
---------------------------------------------------------------------------
   24-   38 (27.81/14.98)	LPPTPQ.AVKMEESFP
   41-   56 (21.71/10.13)	LRPFIQkSAREPDSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.43|      14|      16|     249|     264|       2
---------------------------------------------------------------------------
  249-  264 (21.57/17.23)	QCGflEATPTLRDRGL
  268-  281 (23.87/12.18)	RRG..DGGDLILDRGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     282.32|      93|     279|      65|     168|       4
---------------------------------------------------------------------------
   65-  166 (132.11/108.01)	QRGSFRNVTeQSLQAEIDAQRARAAAGLEAE.ETEETESQEVKSTdrlEQLFKSRaeivDFVAQAHAEaNYALDLVSLLISKYTPRQAEISMSPY.LKQKAPLG
  514-  608 (150.21/91.50)	VTGTFLSPT.SNFKIRIVTNISPNGYGTEFEiATNMTSGSRTKSS...SSRFGLR....DDLQQLLLH.RFTIDLVYLIPTLAWDTGTESSPPPIsSQQKQEQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25908 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EIDAQRARAAAGLEAEETEETESQEVKSTD
2) GTESSPPPISSQQKQEQGQAQVQTEQTHFNTPVQPRASHPTPWTPTSPENGELVASSPTQRRSKKLNI
3) RTDLQEALEVLEQPKPNQLPPTPQAVKMEESF
80
591
6
109
658
37










Molecular Recognition Features






MoRF SequenceStartStop




1) FPLPLRPFIQ
2) PIRIA
37
56
46
60