<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25906

Description RNA polymerase II mediator complex component Srb8
SequenceMISHSSSRRPPSRPPAPSRGSSSHSVVPYPASDSYPAIDSRAHQNEVIDLTESDGGGMADIGRPAKRPRLDVGNEPPQSSLDHTHNQHQQQQYQNQDQPSSQHHVSSMTGETPESSMNPLDLMSSSSTEQTGRPPWSFKGEIPRSDAEAQPEASQWPQSSSLPPLPIRPWKYGPQERYLAGTTDSKGGKECGAVKTTPYRIDVPSIAPRFADNKPADFSPWRGSHPEDVLSEQTAKQGFYDRASVSNETTSAKSVVYPQFKNRSGLKLLSSVFAAALEKRQALRTITAASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLEAKWVRDWTISVQQFVEGVIAGIGDANWRLRISYSIRLSARLFLEHLVEQDHFLEWFLTSFHNSSVENLPVWLLMVGIYWENIVRYRKRGKRLAECLLEKLRLATEADQHAHLNPLTRRLSRLTKTLSLSHPSCFILPRCWDKYENVLSSCLDMNLSDDKAGFQNLKARNARVCRLGNSRRKPTQSTNQRLIQLLDSSSDVSTIGTECLNISQDYSTLATKVIEWASTSFRYGLARIYTAVRVFRRWKKTGIDIDSHLLSFLVQDHRKSGVRFLDVYHVICELVRSQSFSVAKYLQWLMARGSVSNVLGCPQMHIPGDIGLLGHLPSSRLPNHIWNLRNTLLSRTGFLVALEVDTIQRIKASVRRRLPNMFPKAPPEGDAEMTDDVDFSSLSWTVRSEIGNWIRDQVASHVKDSLKSAMDRDFGSEVKTSALIPQEFFEVRYILECLCDLSMLADVLKYASGSDNVTVLASAVDTLNCHLDSFNAIGATSDLFKSFTSAYARISKAELSVQDLIASLLDVAIKLPGELSTVSLLRRDLLQRDRKLAMAACSPVSDHIVDTLNTSNPTFTEELDQLLTSGNSMDESTVARIFDSLCKRLEAGSVNGEQCAHDIARYFAQLRPFNAKLFDNLMIKWVISVLRSSPRPNLSTMLPPLIGVGCVTLHSFYVLARALLHSDVHKSTIPDLAELRISMIQLLDSRLSNGNGSQDLVAYRFKIARQEYMRQFSGEALGLIHDLLAELSEGGTDSLPKQFNSELLSTVVTPLLCEIIVRHPATISADYGIRLLEKFPACINLTDRALGHLLASQVQSGLVAAEETIESINDFSLPLCLMKLRLLFGFECDSNVKKRIYDVVFETAKSNMRKGQSHWIDVVGSLHADAAKEIRQRAEEQLLSHVLTSDSLPTSPTSESNTPPGFNVSALVCLRIVEDLSFSIPETGSPSLCPTLIEKMNMILHRITTLENNLMEANISQDNDHATAIRQAHVVQQSSVIAFWFSVLLRLIAIHRSRFAPGTLSKSDLADQTRLLISINCIALSRTLSPKAPACPRPFPSTSPLTLTTPLQEPRPHFPFHVTDTGISTSLQIQALDVAATLLDSIPDDYRHQCARFLRDRCPPFLHPQNDPRLLFLLGPLAADNQPSPTTTQSSQQQPGGSTLSQANPGTPGTPATPLVVASVGATAASQSSQQFQGGNSYNAATFNPFDDQNSIVGKLRVQQRGRIAGPYPLRPWEMLEESAPVIGVNDTAVNLGWFAARRIRGDVA
Length1635
PositionKinase
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.07
Grand average of hydropathy-0.249
Instability index50.18
Isoelectric point8.57
Molecular weight181148.11
Publications
PubMed=26439490

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25906
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.79|      27|      35|     113|     146|       1
---------------------------------------------------------------------------
  113-  144 (43.05/32.22)	PESSMNPldlmSSSSTEQTGRPPWSFkGEIPR
  151-  177 (54.74/22.82)	PEASQWP....QSSSLPPLPIRPWKY.GPQER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.71|      28|      35|    1506|    1533|       2
---------------------------------------------------------------------------
 1506- 1533 (50.18/31.30)	PLAADNQPSPTTTQSSQQQPGGSTLSQA
 1544- 1571 (47.53/29.22)	PLVVASVGATAASQSSQQFQGGNSYNAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.18|      33|     166|      20|      75|       3
---------------------------------------------------------------------------
   15-   51 (45.91/56.90)	PApsrGSSSHSVVPYpASDSYPAIDSRAHQNEVIDLT
   74-  109 (54.27/20.35)	NEppqSSLDHTHNQH.QQQQYQNQDQPSSQHHVSSMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.54|      67|     170|     318|     391|       5
---------------------------------------------------------------------------
  318-  391 (106.21/95.35)	PL.RRLSR...TIPHGIRGKVLLDQCLGKSIPIcraiwLAKCVGAN..ELRA.FKR.KGTSAGVASGLEAKwvRDWTISVQQ
  492-  566 (100.33/69.02)	PLtRRLSRltkTLSLSHPSCFILPRCWDKYENV.....LSSCLDMNlsDDKAgFQNlKARNARVCRLGNSR..RKPTQSTNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.42|      22|     117|     657|     680|       6
---------------------------------------------------------------------------
  657-  678 (40.19/22.81)	ICELVRSQSFS.VAKYLQWLMAR
  776-  798 (32.23/15.88)	IGNWIRDQVAShVKDSLKSAMDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      19|      37|    1067|    1086|       7
---------------------------------------------------------------------------
 1067- 1086 (27.94/20.64)	ISMIQLLDSRLSNGnGSQDL
 1107- 1125 (31.57/18.43)	LGLIHDLLAELSEG.GTDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.44|      17|      35|    1153|    1169|      11
---------------------------------------------------------------------------
 1153- 1169 (30.11/19.08)	ISADYGIRLLEKF..PACI
 1189- 1207 (24.32/13.95)	VAAEETIESINDFslPLCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25906 with Med12 domain of Kingdom Fungi
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