<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25902

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDSIDVDDLFGDPTSLELGLEGAAPTIKGLPQRLDELRLSGCSQKIAWSKLGAIAYVSQDGQKVLLRCLHCRPDNGKWTLSEESPINQIVDIHGGHTVVHLLWNESGSELAIVDSCGRIAIVTIMMSLNTVNQPRQASIDPDDDLAQPVGLMWLNLNRPLFGFHKATRTNNNRWNYPAYRRRPLGPLHPVNKSALVMVTKSGYIKLIYQNPDLRWGEISSELKTVGYLDGLLTHAALAPAEGSGISIATHSACGKVCFYRVQVKWDPPEWDQTIKPGGGSIAFPTPAFQVLHTKTEVLSAVFHPPAHDMDNITGFSPPNGAIYNLTHLEIITAPQLLPSTQAATGPCILAVASISPQNQLGQPPPCGLSSVLVRWQLDTMAQALHPSFDDVVSKKTASNPKSKIIFRRLDDIYFERYVVSIDYTEASSVLAITHDDSSISFFEARSMRPITENEDGNTVTSMPNAGFTFPIDASGLHIAFSPSGCIAAVLDGEGQFHLRYMEHSFGMEDGMYDSGKFTCAIAALALGYVRACGSDASADDILAVIVRQLNPDAQRTFVTEVYSILFTSVDFTEHDKLVNNQSIQKGLSMQAVLGFRSRFQPRAPSSTVSWIILNIRQIMVLLLTVSHYLKNGKDSTPSEPEVLRMVLGNVKWILDLAKYLVDDLLEIADTIPADRTSFTLSSKTYESPSLILVLSSIPRSFLRHIFRYLGRFPLTFKAANNLSGESYQLFASINDTIDQSSLKPDVCEKMLAHIDSIVTRTYEAAGFGSAERNAPEREMLITCSIPPVLQPAVMSILTETVPLVVRPGVERMALALYDYSWLGIGDDKRTELFKRTHDVDILKKNVGKVLDATVAKRRCVRCCEVSEDTCLPRSASMYRLIGKIGVLRTCVCGGSFAMENVEALDRVSLPVYR
Length918
PositionTail
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.034
Instability index43.36
Isoelectric point5.96
Molecular weight101128.88
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25902
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.60|      16|      18|     425|     440|       1
---------------------------------------------------------------------------
  425-  440 (27.47/19.54)	SIDYTEASSVLAITHD
  443-  458 (29.13/21.19)	SISFFEARSMRPITEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      14|      22|      94|     107|       2
---------------------------------------------------------------------------
   94-  107 (25.07/16.67)	IVDIHGGHTVVHLL
  117-  130 (24.57/16.18)	IVDSCGRIAIVTIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.37|      53|     430|      31|      84|       5
---------------------------------------------------------------------------
   31-   84 (93.93/77.16)	TIKGLPQRLDELRLSGCSQKIAWSKLGAIAYVsQDGQ.KVLLRCL.HC......RPDNGKWT
  463-  523 (83.44/62.97)	TVTSMPNAGFTFPIDASGLHIAFSPSGCIAAV.LDGEgQFHLRYMeHSfgmedgMYDSGKFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.51|      11|      18|     344|     354|       7
---------------------------------------------------------------------------
  344-  354 (21.38/11.80)	STQAATG...PCIL
  360-  373 (18.13/ 8.88)	SPQNQLGqppPCGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.51|      22|     132|       8|      30|       9
---------------------------------------------------------------------------
    8-   30 (34.87/23.09)	SIDVDDLFGDPTSLeLGLEGAAP
  143-  164 (42.64/24.37)	SIDPDDDLAQPVGL.MWLNLNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.39|      23|      47|     198|     220|      10
---------------------------------------------------------------------------
  198-  220 (37.67/24.74)	SALVMVTKS.GYIKLIYQNPDLRW
  221-  242 (20.27/ 9.96)	GEISSELKTvGYLDGLLTHAAL..
  248-  270 (38.46/25.41)	SGISIATHS.ACGKVCFYRVQVKW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25902 with Med16 domain of Kingdom Fungi
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