<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25899

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVIDDFFDIFWRIYSIVAPESDGSQFGPVESSTLRNSNEIWSSLFALRNAGCLVSQLADRPELWIFSASPDFDALARASGNHQPREGLIVAGNATFLNVASGVNTAAEIKQHLLSGPSSSIFNGAATQNRLSPHVGEYSQLQNLATYSAFHEALLSSISKTVTLQFTRQQKVVPLGTRTLYASLNENEYQGGEDSPLARKSTPFLSTLDINLTSKGRLVISLSTLPQPGLEQLHHDSESDIIATRLNDDVWLAPSGTLCRLTSTSEYQSSLSNVVSPDPMGTTPHHAELPADKINANKREWKKNVSEWLKMFGLHLNNPESEFWVEVEVNVSDRPFCDLFSKSALNHQKSSPFIRILWPGRLCFTRSRSKLTAPANPTEFFSGQSESPLQFAERWVKEVCRISQPIDKHKSSDDQSGLENQQLKRSEPSPLRLDRSDMPESLARTINMPEAQLASAVYPTPPGGALAQYMGAGSISERLGTSTIDTLSYAPTQTESIYNEAGGPTTYFRGNSEILPTALDPASSELGIGSGLYDTAADEEFFGDMDVANFDTKGITEADFNFFDEPDFTGLTDNLDMQTEEPELAQQHAESNLATPYNSNTAMSIAEPNPSNTNQGHLITTKNGNGRIKHSGVSPLNTTAAEGQISEGITQPRQLILTDGLRRRPMSPPLSPVQIKKILSPDVSSPLPSKPLNSKISKSCPAKNQYSPVIFQPTLWTSDKKYRMDGRFWFTPGSQHITRNLRSYPSDIPTIGFPQKGKNVRPKPPSIHTSSGPLVSDNAPEIDLQSPSTSSYGSSDYDSDTDRGSNASSPHIIQFHSKRKRDSEGGGNSTPSHLERLTQASDVDNGTLNEHELALLSIFISGAVDWPLAGYFSRIQNDVFPVFSRREDLLQTAQLVVDQVTQSSFCHVHDDLYMPEWVDWDDVLSQSLFDNTDGLGHMSKLDLRSYTTLEDGSNPRKEVPSIRPSIPGSIYKISSPHVKVHRGNSYLEILPPAIGFWETFGLEPLQGEKNIIPFCIYPPNVSEAADAFMERLTLVYSSGNFGSHSRPKKANGLVPWSLNAASDQDYASLMHALNVSCEILGSALSNILASDENVVIYIINPFVYDAAIVDICSAFLRLFHKYVGDADRQHTRRLNELVLQIIPLEFIASPDSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCAPPLVLAEPVPKVVPFRLAPESITPVEEAKCLHVAYSQSVDQRWVTAAWTDNSGRHQTALSYCLRERNSPVSRPISEIRTQIWETTKDIMDMSSSHWRLIIVKDEPVDSEEIDMWKSLLDQYNRHKAIKVELGIVSVNTKPGLSLRLPSSPLQFSALSQQPTQNGLSTVTPGSTPRPVPSPDPSGPAATPPTATTPMFADQQQATPPQQQPQQLTTDSDQDTILIDKSDETWGVTLSHRLNSSYSLTKYQPALASGYLLRRSGTSDTDGQAVMTVNVIYTNSRRPIDHLLKDILRMYRELITLARVRGIVHVQGNLPLPWHIMTAVKGQEVLSYTL
Length1531
PositionKinase
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.400
Instability index53.79
Isoelectric point5.43
Molecular weight169060.49
Publications
PubMed=26439490

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25899
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     777.54|     261|     402|     201|     487|       1
---------------------------------------------------------------------------
   46-  291 (293.82/144.18)	.......................RNSNEiWSSLFALR..NAgclvsqladRPELWI.....FSASPDFDALARASGNHQPREGLI...VAGNATFLNVASGVnTAAEIKQHLLSGPS.SS.I.FNGAATQN..RLSPHVGEYSQLQNL.............................................ATYSAFHEALL......SSISktvtlqftrqqkvvplgtrtlyaslneneyqGGEDSPLA....RKST...PFLSTLDiNLTSKGRLVISLSTLPQPGLEQLHHDSESDIIATRLNDDVW.LAPSGTLCR.LT.................STSEYQSSLS.NVVSPDPM
  293-  487 (233.74/146.93)	TTPHHAELP..ADKINAnkrewkKNVSE.WLKMFGLHlnNP.........ESEFWVevevnVSDRPFCDLFSKSALNHQKSSPFIrilWPGRLCFTRSRSKL.TAPANPTEFFSGQSESP.LQFAERWVKEVcRISQPIDKHKSSDDQSGLENQQLKRSEPSPL.RLDR.SDMPESLARTINM..PE.AQLASAVYPTPPGGALaqymgaGSIS....................................................................................................................................................
  737-  828 (66.41/20.80)	..........................................................................................GRFWFTPGSQHI.T.....RNLRSYPSDIPtIGFPQKG.KNV.R.PKPPSIHTSSGPLVSDNAPEIDLQSPSTS.SYGS.SDYDSDTDRGSNAssPHiIQFHS.........................................................................................................................................................................
  840-  976 (94.06/34.07)	..............................................................................................................................................................STPSHLeRLTQaSDVDNG...TLNE..HE.LALLS.IFIS...............................................GAVDWPLAgyfsRIQNdvfPVFSRRE.DLLQTAQLVVDQVT..QSSFCHVHDD.........LYMPEW.VDWDDVLSQsLFdntdglghmskldlrsyTTLEDGSNPRkEVPSIRPS
 1383- 1448 (89.51/37.21)	ATPPTATTPmfADQQQA............................................................................................................................................................................................................................................................................TPPQQQPQQLTTDSDQDTILIDKSDETWgVTLSHRLNS.SY.................SLTKYQPAL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.31|      21|      24|     576|     597|       2
---------------------------------------------------------------------------
  549-  571 (19.64/ 7.07)	....DEEF.FGDMDvaNFDTKgITEADF
  572-  595 (31.26/12.63)	NffdEPDF.TGLTD..NLDMQ.TEEPEL
  597-  620 (18.41/ 7.56)	QqhaESNLaTPYNS..NTAMS.IAEPN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.10|      11|      25|     687|     697|       3
---------------------------------------------------------------------------
  687-  697 (19.00/10.54)	KKILSPDVSSP
  714-  724 (21.09/12.65)	KNQYSPVIFQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.91|      24|     470|     507|     546|       4
---------------------------------------------------------------------------
  507-  530 (45.38/44.36)	SIYNEAGGPTTYFRGNS..EILPTAL
  980- 1005 (40.53/12.92)	SIYKISSPHVKVHRGNSylEILPPAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      15|      15|     632|     646|       5
---------------------------------------------------------------------------
  632-  646 (26.52/20.06)	TKNGNGRIKHSGVSP
  649-  663 (25.02/18.40)	TTAAEGQISEGITQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.03|      52|     299|    1007|    1064|       6
---------------------------------------------------------------------------
 1007- 1064 (83.08/66.02)	FWETFgLEPLQGEKNI.IPFCIYPPNVSEAAdafmeRLTLVYSSGNFGSHSRPKKANGL
 1309- 1361 (84.95/51.60)	MWKSL.LDQYNRHKAIkVELGIVSVNTKPGL.....SLRLPSSPLQFSALSQQPTQNGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25899 with Med13 domain of Kingdom Fungi
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