<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25895
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPGIIMDGTSANGPRREADHQQLVDGTLSTTTSLAPHNNGDYSNGPSHTEDATRLSNPSFDDSLPPELVHISQGFFSLGHLINRAAQQCWNDLTDLITELADPQSTATHVAAPPISTTNGKYTPSQSATENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLSTGRVAAMQESSFVPPKPLTQKNMLKTLKKINKTIRTRLVLHDQIPSAFTKYLINDGRVTFKVPMEFEVDLSIAQENHSSQFFFVDIRFLFSPSPPKPTGRLLDELDNRVNAMLMHSGLPGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEVLHRTLVVQYWANRPGPKSWVEIGIKSGRRKDQTQDGSITETPFLGLRWMRDNKEVESKYIKFDMELLSIEAVLRSVIALHTSFLLESTYTRLLQGRLYASGALSASLQMSISEPGDCLFDVQLTKGRNLRVMIEPVSGAIIFRPTPLLLNRHDIDRSFERPIVDDILLRISRLRSAAVIEEVESLADALGWEIVNSRDIKNEDLRRIFPPNILRSVLFFRKSWECNWGVAYTCSMDGDNWWVVELRAPSSDEGPVSPQSAHMVTGRFGGLPERLNYGSFGKLDHALSGMLAIHANARYLSELHGIHHFPPIRNLSLGPHLQVPSVFIRFRSRSLPSGLQISPPIITNKNPAIKDTVRLSFQGIDLSTQYAILLAHGTLSSEIKDLALPASHLDPTVTFQPNGCGFAMRFLTPVGQPMIIQLLARLQQLERVISTLETLKQKSLKPLSVNLSKIKFAYAADEDARASINFNYHEQTLASDINSITLLSKQTPLMLLRMSIDFHPQNPHRRIKESLTATLNGLRPAAGSGTGLEAVLQLLVVTLPVLKALDRMTTESHVGHPANSGLQITARSSKIFYIRYASIRYRFCVHAGLRRDRVVWILREMTIAPEKAGRQPLENKLKEHIYGARGDGWQGLGNGAIAEYEKIGNLLSTLHRVMAEYISSEAGGASGSNTLGSRNGASGGGPGPAPDGRSGSSGGSGLGPEVRKAPQPQLSGRGAADSKSRLIPGQAGMGVDMQGRPGGLGGTNTPKPASNGMAMGTQTQSDTKAVKQNTKIPQSNKSTHATGAMANGNNGNGNGNGSGSGSGGSRDVDVIMID |
Length | 1188 |
Position | Tail |
Organism | Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.259 |
Instability index | 42.30 |
Isoelectric point | 9.37 |
Molecular weight | 130337.33 |
Publications | PubMed=26439490
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25895
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 171.45| 42| 99| 1028| 1073| 1
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1028- 1073 (69.90/41.20) MAEYI...........SSEAGG..ASG.SNTLGSRNGASGGGPGPAPDgrsgSSGGSGLG
1089- 1130 (65.26/30.57) AADSK...........SRLIPG..QAGmGVDMQGRPGGLGGTNTPKP.....ASNGMAMG
1136- 1181 (36.29/12.73) DTKAVkqntkipqsnkSTHATGamANG.NNGNGNGNG.SGSGSGGSRD............
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.00| 25| 99| 748| 772| 2
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748- 772 (43.72/27.90) TLSSEIKDLAL.....PASHLDPTVTFQPN
846- 875 (38.28/23.50) TLASDINSITLlskqtPLMLLRMSIDFHPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 156.52| 37| 46| 300| 336| 4
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225- 262 (34.77/18.76) .....SFVPPKPlTQKNMLKTLKKINKtirtrLVLHDQIPSAF
300- 336 (68.40/44.30) IRFLFSPSPPKP.TGRLLDELDNRVNA.....MLMHSGLPGCY
348- 380 (53.35/32.87) ITILFHQAIELA.RGHWLDTL..RVE.......VLHRTLVVQY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 249.49| 75| 357| 586| 660| 6
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586- 660 (139.75/89.09) SVLFF.R.KSWECNWGVAYTCSMDGDNWWVVELR.AP.SSDEGPVSPQSAHMVTGRFGGLPERLNYGS...FGKLDHALSGM
943- 1024 (109.74/68.18) SKIFYiRyASIRYRFCVHAGLRRDRVVWILREMTiAPeKAGRQPLENKLKEHIYGARGDGWQGLGNGAiaeYEKIGNLLSTL
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