<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25891

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEEIKIVGSSSAQWKTLLRRCLSQRTDASEFRAFAKLMLNRYSIPARRLIDIILALRCVTNVPWDPLIPLYVDTLHRLGSIKLEDILESLLAQSTVSQKQVAAQNGSTTKAPVSTLMTDYCIIHNATIAATSGHAPRTTSDAANTFSALAKWILALLSWNSSREPVGDPAASLTNSPDTLAVFESLGILFAALMSTEKAVNALSASGPKGWRNKLGQSLSEYIPLCGGVSIPLRDRLETLRKDFNLYGHDGEKSLEDAMMENVNISALEFESNVLDGSIINSRAGPYIYVNALLFGRPLVDDSMVVNYLNNRYGGDRMTLIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCASAIDPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREDLVSQINNNPERAEQLINELESMEGNAGTIAAAITEVMHNLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILRPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKYKYGLSHYDLGISNPDSFILRLLQHGCSSQRLEDLDEKQKNNLGAWITALFIAEGISDESMSSCSPQEFYFLVSTLFSQSLAACETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLTTSLKLLLALVKPSSISGEAQEIHRTVLLITAKQLGDQLKGVRTRHLSRNDIKPILEALEPYHSFQRRSTARYGEVEGWASNPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPVDPSKDAIPRCPILTLRDGLNLERESIPKLIDSDTLRAELIVRLSRRVDALTAVPQMPQEVSNIDVGNIMQGINLEREGMGMSGQRHDQGGEQSGQQNQGADDTGDLNDMLDAAVAAAAGGDGAGNGQGMGMSGIGEIGMGMGSGLDASIDDVLNGADMGVGNPEYLDLDMEGMF
Length1041
PositionTail
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.07
Grand average of hydropathy-0.039
Instability index43.57
Isoelectric point4.94
Molecular weight113861.79
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25891
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.04|      78|     452|     413|     497|       1
---------------------------------------------------------------------------
  413-  497 (121.16/97.16)	FA...CALHKLIP.EASIERllgeNPMQTLPVGGQLRREDLVSQINNNPERAEqLINEL..........ESMEGNAGTIaaAITEVMHNLCSRKETMTL
  857-  948 (119.88/77.44)	FAverAAFHPVDPsKDAIPR....CPILTLRDGLNLERESIPKLIDSDTLRAE.LIVRLsrrvdaltavPQMPQEVSNI..DVGNIMQGINLEREGMGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.93|      28|      31|     753|     782|       2
---------------------------------------------------------------------------
  753-  782 (44.97/33.69)	SFQRRSTARygEVEGWASNPAGGGIVASIR
  787-  814 (52.96/32.48)	SFVFWSTSP..EISMTPPSYTHRQIVAGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.87|      35|      36|     955|     989|       3
---------------------------------------------------------------------------
  955-  989 (60.34/37.11)	QGGEQSGQQNQGADDTGDLNDMLDAAVAAAAGGDG
  994- 1028 (62.52/38.72)	QGMGMSGIGEIGMGMGSGLDASIDDVLNGADMGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.02|      29|      31|     641|     670|       4
---------------------------------------------------------------------------
  641-  670 (45.09/34.97)	SLAACETGKLEFET.LKGGFEYLLePFLLPS
  674-  703 (44.93/29.77)	ALTWLGHHIWESESdLTTSLKLLL.ALVKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.17|      77|     340|     211|     297|       6
---------------------------------------------------------------------------
  211-  297 (106.05/75.43)	WRNKLGqsLSEYiPLcgGVSIPlrDRLeTLRkdFNLYGHDGEK..SLEDAMMENVN..ISALEFESNVLDGSIINSRAGPYIYVNALLFGR
  560-  640 (126.12/61.07)	FKYKYG..LSHY.DL..GISNP..DSF.ILR..LLQHGCSSQRleDLDEKQKNNLGawITALFIAEGISDESMSSCSPQEFYFLVSTLFSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.85|      22|      36|     354|     375|       7
---------------------------------------------------------------------------
  354-  375 (41.50/24.48)	NKLPPF...FAEMCASAIDPIPMEL
  387-  411 (34.35/19.10)	NAFPSFsemFAMQGNSILSDVRQEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.83|      18|      36|     141|     158|       8
---------------------------------------------------------------------------
  141-  158 (29.63/15.44)	DAANTFSALAKWILALLS
  178-  195 (29.20/15.12)	DTLAVFESLGILFAALMS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25891 with Med5 domain of Kingdom Fungi
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