<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25889

Description Uncharacterized protein
SequenceMSSSYSQPLAGFSGLPVARTAYRQARKVLGSDLERGIGPGAKVSPVIDLTGSNDEDEDQEPSRPVKRLRIDTHAHDEPARHMNIGSRPGLGLLGGEKDGEGEDDDDQVMADEVAATPFVIESTKPPATFQDRLAYMSIDGGGQQPQSSSSLPLPLPPRPPRTMFVRDGQPGFEDDEQEDMVVQTTPYTMEEPAAAARLADNTILDFHPWTGNHPEDALNEQTAKQGFYDRVQLSQNESNTARPSLYSHFKNPNGLKALSHIFTAALKRREAITKITPASTFKPPPRVTLTDNKREAWLRDLANQTVPLRRLSRTIPHGIRGKILLDQCLAKNVPIGRAIWLAKCVGANEIRAFKRKGTAAAIASGLETKWVRDWTGSVQQFMEGVVQSREETGWIENQAYAMRLTGRLFMDQLLDQDTFLEWLLSSLQAASLDLLPVWLSTLGIYWKNLTNYRKRGRRLAQILLDKLAFVWFPYYLSVSFCLPRTDGIYFQTLNNNQSAVLNPLIFRLQSLIRSFITSHPSSFILPLTWSQYHKPLTACFNTSNSFEVNFLTHLTERNNRLSKTNPQSNTNSPQSTSRPAPQQLISYLDLAYTHNVFPVLASKCLSLPLDHRTIVYTLLEWSSTPFRYGSTRIYVSARLLRRWRKLSIDTDAYILSFLAENNQHTTRQFENIYHVISELVRSQSFSVGKYLEWLMARGAVRSPDAFDQCLSADVELLRHIPSSRLPEHIWNLRNTLLSRAGVSVDAETWQIRQIKAGLQQMYPDIFTEHVDTPYAEMIGADFDWASLTWTVRSDVSHWIREQIASKLHAQAQVQPSSGAITQRAPIILRPGQFYSLRSILERMNDLPILADILKLLSQSTNPTVLASITDTLNYHFPSFTAIGATMDLFQSFALSYSKISKVETHLQDFIVALLDVALVLPSEASTVAVLRRDLARCEKKSAMAASSPVSEHMADTLNPVNPTFSGMLDQLLASGNCMDDATLMRIFDLLIQKLETGKADISLSFSEAARYLAQLRLFNPKTFDGLMMKRVLGIIRTSPRPKLSEFLPPLIGVGCITFPAVLGLVKKLVDTDRVGARNIPDVMQLRLDMLSVLGLENADKMVVPDLVFYRFKISRQEFIIKHFCGIVGTIRDVLIDASASNSSIDGTLQEQWNKSIFPLLCELIVRHSKVAKDECVKWVTEKFPTGLRLLAQTLDSLLNVESSNVLDDEGRRQIQQKAESKLLLLFITSATSALAGPSDDTDEALTPYELGLVYLRIIEELVYKAPRNSISSPIGNALLERMNLLLQRTSFLTKVKTAEMNPANTTQRHEGGILGIWVYILLRLVSLYRSVFVLERASKADLTDQTRLLLSICYLAFTPGLGQVFSRIGDPSTVPIGKYAHLYQSIPASWHGLRTYAVDVATILVDTLPDDARLQCARFLRDRSPLFVQQQDNRLLYLFGPMPDPQASSSNSSNATATSAPPIPGSSPLNVQNHAAQGGQAQVLHQTSSSIPTVEETNSPIQNFRFQQGNRVIGPCPPRTWEMLEESAPVAGVNDTALNLSYFGARMVRPGLK
Length1553
PositionKinase
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Microsporum.
Aromaticity0.08
Grand average of hydropathy-0.194
Instability index45.37
Isoelectric point8.01
Molecular weight173466.21
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25889
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.99|      44|      89|     839|     887|       1
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  839-  887 (66.02/75.34)	ILERmnDlpiLADILKLLSQSTNPTVLASITDTLNYHFPSFT.......AIGATMD
  929-  979 (72.98/62.38)	VLRR..D...LARCEKKSAMAASSPVSEHMADTLNPVNPTFSgmldqllASGNCMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.82|      47|      90|     185|     235|       3
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  185-  235 (76.28/54.12)	TPYTMEEPAAAARLADNtilDFHPW...TGNH..PEDALNeQTAKQGFYDRVQLSQ
  276-  327 (73.54/41.58)	TPASTFKPPPRVTLTDN...KREAWlrdLANQtvPLRRLS.RTIPHGIRGKILLDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.75|      24|      68|      82|     107|       7
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   82-  107 (39.16/31.16)	MNIGSRPGLGLLGgeKDGE.GEDDDDQ
  153-  177 (42.59/26.84)	LPLPPRPPRTMFV..RDGQpGFEDDEQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.50|      77|     633|     743|     831|      12
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  743-  831 (119.33/102.64)	SVDAeTWQirqikaGLQQMYPDIFTEHVDT.P.YAEMIGADF..DWASLtWTVRSDvsHWIREQIASKLHAQAQVQPSSGAITQRAPIIlrPG
 1385- 1465 (127.18/77.83)	SIPA.SWH......GLRTYAVDVATILVDTlPdDARLQCARFlrDRSPL.FVQQQD..NRLLYLFGPMPDPQASSSNSSNATATSAPPI..PG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25889 with Med12 domain of Kingdom Fungi
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