<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25886

Description Neurofilament heavy polypeptide
SequenceMNISVDLKDTSRFRTTAKKKKAAAKKPTPANDSWADENSKEGSGAGKEENQGDGANGGEGGGDPGGAGGSGGGDDPGGNEDKGGGEGDGDQSSGKKKKKKKGKKDDEEEEKKKREEEEEKKRLEEEEKKRLEEEEEKKRLEEEEKKRLEEENKAKAGADISWADDTNPEDWGFPGATTSKKKKKKNKGATELSPADPPPTTFQDVSLDDGGATPHINMSFGGDDTKASTGFGFGVWGTDWATGGKLDLGASGDGKNDSLNPWGGTGKNKQNTSGLDFSFGSAGIDDKPANTTAAKEPEDPWPSATAGKGKKKKKDSIGFGSTPAETEEKVPETEDWNEFSGSTSKKNKKKTTSAWGAIDEPSNDGVDFFADLGKNDEAAEPEPAPEPPVEEQPAEETPAPTKKDKKKKKKKAGAVEPEPEPEPEPEPALEPVKEESPVEEKPGENREDFGGATTTSKKGKKKKKDDIVDGLVPEPQSELPKEEKPVEVVDESWANVPALSSKEKKKKKKSAAAAETVTGVKPEPEPVVEAPLEEKQVGGGFWDSLAIPSSTKRDKKKKNEVVTAPVIPEPEPKPAVVEPEPVEEEGPIEPTGWGFGLPNSNKKKKKKSAATDPPPPPPPPPEPEPEPIVEPVEEIKEEQPAETFWGFTTKKDKKKKKNELEPAPVEPEKPKDLFDNDDSWCNEFDQDKELKSAGADLLDDGPKVDDSTWMGLTSSKNKKKKGKTTADTVTPGAFDFGDDPALEATGGADEVSWFGLGKKKSSKTDDPFEIPEFVDEVVEDTVPKEEEKKPVKETKLSKKEKKKKAAAAADPAPEVPAAEELPKVDFFEDTKEEPDLLASPPVDGFDSWGTRVTTSKKKDKKKNGAAAVLPNPEPELAPVVEPVEATDVGFGWGTGGTTAKSKKGRKGSAAEENIASKALEKDPFALDDIIDQPATDTKKKKKKGQKSTIEVVPNADPEPEPEPEPEPVLEPEPEPEPEPEPEPEPEPAQPSSWSLWGSSKPTKEKKSKSSKAATETIEETDKAAKGKKGKKATEEVIDVLPQDEGVGSGELVPVPKVADEGTWDIWGTITNSKKKGKKGASELPPPAPTPPEFPPEHGGDDITNTWDDITAPWPSSMKKGSLSRTTTSTSKASHVEESKLSKTKGKGLEVVDVSENPILETPIEDVSASNAAKGYWSSFGLASGGKAVDGADDLLDLVDEEEPKPASKPTSKADKASAKSSKKDSKKEKDAKKEAKKKKVDVAKEEEKEDEGWLDAASAPTADKATKQPTSAAATTSAPKAPGKASVAERIKQLEQSRKTEKEDTKAKESSKSKEKPKPEPPAPAEPVPEPEVLEPVEDLSTKPAKPSKKDAAASKTKSTSKTKSKSKSKADKGEVLDVVEPPVAAKEPTPRDSVPGSFPGAFDDLADIDEPEAPEPIKMAEEEEEAVEAPPPPPPEPEVVEVRELPSEPDAASLQRPSTAKADGDGADTMPASTPKKGAKKERARIDRTAGAASWALWGAAGASGPAPKKSSKKEPKSKDTGEPPVIKKDKERPSGLSRSKSSATKREKVSSLGAEVEKSSGSDKDRRPSRPSKHSRGMSFPFMLSGPPPTRSKSTKRASASKPTSRRHSIEIDDSGLLTPRESPDIPEKAAKTMGVESSKRVKRSSSHKKRSGPRDPYALDDDIDMLSPDDGLVSPPGRSLRDQEHRRKSRKESKKHNSDPALSPPGPEMPMGRDDFGINHPSPREPAPLRRANTSPKRPEGLFGFLSLRKPAPRAPEVRERPKSRSRHESSRRDTDREKDDSKRRKRSVRPDTDGEGFTTDAMRTGNNSPTEEAEARRAKRKAERARLREERDEKAREIEREGRRYKRHAREMEDVLHESKRDKKADRRSRSERPPKDPLSPTEGRRHRSHRTDDEGGKPRRRKSSPDNHRPRREKSSRHDHAVPYPVMVNGGKDKTSSWVKSQISDPPEAPPIVATVVDMPNPAREPQNASLSSDEEARRAIHRRSRRKSRAVDAMDVDVDRRPRRRESRREGRDPVRSNESSGDMDNRYGGMNPKRTSWFKKLTSGF
Length2052
PositionTail
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Microsporum.
Aromaticity0.04
Grand average of hydropathy-1.290
Instability index61.85
Isoelectric point6.08
Molecular weight222832.07
Publications
PubMed=22951933

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25886
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     489.54|      48|      48|     518|     565|       2
---------------------------------------------------------------------------
  307-  343 (35.67/ 6.36)	GKGKKKKKDS...................igfGS...T...........P..................AE..TE...E...K....VPE......TEDWNEFS...GS.T
  344-  400 (41.95/ 9.37)	SKKNKKKTTS...AWG.....AidePsnD...GV...DffadlgkndeaAEPE..P.AP.......E.PP..VE...E...Q....PAE.............E..TPA.P
  401-  456 (52.24/14.30)	TKKDKKKKKKkagAVE.....P...E..P...EP...E...........PEPE..P.AL..epvkeE.SP..VE...E...K....P.GenredfGG.....A..TTT.S
  457-  500 (35.14/ 6.10)	KKGKKKKKDD...IV................dGL...V...........PEPQ..S..........E.LP..KE...E...K..pvEVV......DESWAN....VPAlS
  501-  550 (73.84/24.67)	SKEKKKKKKS...AAA.....A...EtvT...GV...K...........PEPE..P.VV.......E.AP..LE...E...K....QVG......GGFWDSLA..IPS.S
  551-  600 (56.21/16.21)	TKRDKKKKNE...VVT.....A...P..V...IP...E...........PEPK..PaVV.......EpEP..VE...E...EgpiePTG......WGF....G..LPN.S
  601-  648 (58.15/17.14)	NK..KKKKKS...AATdppppP...P..P...PP...E...........PEPE..P.IV.......E..P..VEeikE...E....QPA......ETFWG.......F.T
  797-  855 (39.11/ 8.01)	SKKEKKKKAA...AAA.....D...P.aP...EV...............PAAEelP.KVdffedtkE.EPdlLA...S...P....PV.......DGF.DSWGtrVTT.S
  856-  900 (51.22/13.81)	KKKD.KKKNG....AA.....A............vlpN...........PEPElaP.VV.......E..P..VE...A...T....DVG......FG.WGTGG..TTA.K
 1308- 1360 (46.02/11.32)	KESSKSKEKP...KPE.....P...P..A...PA...E...........PVPE..P.EV.......L.EP..VE...DlstK....PAK......PSKKDAAAskTKS.T
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.63|      15|      15|      61|      75|       4
---------------------------------------------------------------------------
   72-   87 (21.17/ 7.02)	GGDDpGGNEDKGGGEG
  254-  268 (22.46/ 8.06)	GKND.SLNPWGGTGKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.99|      22|      24|    1412|    1433|       9
---------------------------------------------------------------------------
 1412- 1433 (29.13/ 6.83)	PEAPEPIKMAEEEEEAVEAPPP
 1471- 1492 (27.86/ 6.09)	MPASTPKKGAKKERARIDRTAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     132.27|      24|      27|    1816|    1839|      10
---------------------------------------------------------------------------
 1598- 1618 (25.30/ 8.97)	K...RASASKPTSRRHS..I..EIDDSG
 1619- 1640 (22.71/ 7.11)	LLTPRESPDIPEKAA....K..TMGVES
 1641- 1666 (23.06/ 7.36)	SKRVKRSSSHKKRSGPR..DpyALDDDI
 1816- 1839 (32.37/14.02)	EAEARRAKRKAERARLR..E..ERDEKA
 1979- 2004 (28.82/11.48)	DEEARRAIHRRSRRKSRavD..AMDVDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     570.18|     142|     304|     650|     794|      12
---------------------------------------------------------------------------
  148-  206 (54.24/11.03)	...................................LEEENKAkAGADIsWADDTNP.EDWGF..PG.ATTSKKKKKKNK.GATEL....................SP.A....DPP.....PTTFQDVS..............................................
  651-  794 (234.58/82.97)	KDKKKKKNELEPAPVEPEKPKDLfDNDDSWCNEFDQDKELKS.AGADL.LDDGPKV.DDSTW..MG.LTSSKNKKKKGKTTADTV....................TPGAfDFGDDPALEA.TGGADEVSWFGLGKKKSSKTDD...PFEIPEFVDE.VVEDTVPKEEEKKPVKET
  901- 1020 (125.17/37.19)	....SKKGRKGSAAEENIASKAL.EKD.....PF....................AL.DDIID..QP.ATDTKKKKKKGQKS..TIevvpnadpepepepepepvlEPEP.EPEPEPEPEPePEPAQPSSWSLWGSSKPTKEKK...S.KSSKAATE.TIEET.............
 1022- 1138 (156.19/47.10)	KAAKGKKGK...........K....ATEEVIDVLPQD...EG.VGSGE.LVPVPKVaDEGTWdiWGtIT...NSKKKGKKGASEL....................PPPA...PTPPEFPP.EHGGDDIT.........NTWDDitaPW..PSSMKKgSLSRTTTSTSKASHVEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.35|      29|     227|    1141|    1169|      14
---------------------------------------------------------------------------
 1141- 1169 (46.19/19.70)	SKTKGKGLEVVDVSENPIL...ETPIEDVSAS
 1370- 1398 (40.12/16.02)	KADKGEVLDVV...EPPVAakePTPRDSVPGS
 1544- 1564 (28.04/ 8.71)	SATKRE.....KVSS...L...GAEVEKSSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.24|      24|      51|    1845|    1874|      17
---------------------------------------------------------------------------
 1864- 1912 (23.26/18.02)	KRDKKADRRsRserppkdplsptegrrhrshrtddEGGKPRRRKSS...PDN
 2006- 2032 (38.97/14.01)	RRPRRRESR.R........................EGRDPVRSNESsgdMDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.36|      24|     222|    1688|    1717|      18
---------------------------------------------------------------------------
 1688- 1712 (42.94/16.29)	HRRKsRKES..KKHNSDPALSPP....GPEM
 1913- 1932 (39.60/10.80)	HRPR.REKS..SRH..DHAV..P....YPVM
 1940- 1964 (16.83/ 7.84)	......TSSwvKSQISDPPEAPPivatVVDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.98|      23|     227|    1566|    1592|      19
---------------------------------------------------------------------------
 1566- 1588 (42.41/16.13)	KDRRPSRPSKHSRGMSFPFMLSG
 1787- 1809 (37.56/12.88)	RRKRSVRPDTDGEGFTTDAMRTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.82|      16|      19|      31|      46|      21
---------------------------------------------------------------------------
   31-   46 (26.36/11.75)	NDSWADENSKEGSGAG
   47-   62 (26.56/11.90)	KEENQGDGANGGEGGG
  217-  232 (26.89/12.16)	NMSFGGDDTKASTGFG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25886 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVDGADDLLDLVDEEEPKPASKPTSKADKASAKSSKKDSKKEKDAKKEAKKKKVDVAKEEEKEDEGWLDAASAPTADKATKQPTSAAATTSAPKAPGKASVAERIKQLEQSRKTEKEDTKAKESSKSKEKPKPEPPAPAEPVPEPEVLEPVEDLSTKPAKPSKKDAAASKTKSTSKTKSKSKSKADKGEVLDVVEPPVAAKEPTPRDSVPGSFPGAFDDLADIDEPEAPEPIKMAEEEEEAVEAPPPPPPEPEVVEVRELPSEPDAASLQRPSTAKADGDGADTMPASTPKKGAKKERARIDRTAGAASWALWGAAGASGPAPKKSSKKEPKSKDTGEPPVIKKDKERPSGLSRSKSSATKREKVSSLGAEVEKSSGSDKDRRPSRPSKHSRGMSFPFMLSGPPPTRSKSTKRASASKPTSRRHSIEIDDSGLLTPRESPDIPEKAAKTMGVESSKRVKRSSSHKKRSGPRDPYALDDDIDMLSPDDGLVSPPGRSLRDQEHRRKSRKESKKHNSDPALSPPGPEMPMGRDDFGINHPSPREPAPLRRANTSPKRPEGLFGFLSLRKPAPRAPEVRERPKSRSRHESSRRDTDREKDDSKRRKRSVRPDTDGEGFTTDAMRTGNNSPTEEAEARRAKRKAERARLREERDEKAREIEREGRRYKRHAREMEDVLHESKRDKKADRRSRSERPPKDPLSPTEGRRHRSHRTDDEGGKPRRRKSSPDNHRPRREKSSRHDHAVPYPVMVNGGKDKTSSWVKSQISDPPEAPPIVATVVDMPNPAREPQNASLSSDEEARRAIHRRSRRKSRAVDAMDVDVDRRPRRRESRREGRDPVRSNESSGDMDNRYGGMNPKRTSWFKKLT
2) DDPFEIPEFVDEVVEDTVPKEEEKKPVKETKLSKKEKKKKAAAAADPAPEVPAAEELPKVDFFEDTKEEPDLLASPPVDGFDSWGTRVTTSKKKDKKKNGAAAVLPNPEPELAPVVEPVEATDVGFGWGTGGTTAKSKKGRKGSAAEENIASKALEKDPFALDDIIDQPATDTKKKKKKGQKSTIEVVPNADPEPEPEPEPEPVLEPEPEPEPEPEPEPEPEPAQPSSWSLWGSSKPTKEKKSKSSKAATETIEETDKAAKGKKGKKATEEVIDVLPQDEGVGSGELVPVPKVADEGTWDIWGTITNSKKKGKKGASELPPPAPTPPEFPPEHGGDDITNTWDDITAPWPSSMKKGSLSRTTTSTSKASHVEESKLSKTKGKGLEVVDVSENPILETPIEDVS
3) MNISVDLKDTSRFRTTAKKKKAAAKKPTPANDSWADENSKEGSGAGKEENQGDGANGGEGGGDPGGAGGSGGGDDPGGNEDKGGGEGDGDQSSGKKKKKKKGKKDDEEEEKKKREEEEEKKRLEEEEKKRLEEEEEKKRLEEEEKKRLEEENKAKAGADISWADDTNPEDWGFPGATTSKKKKKKNKGATELSPADPPPTTFQDVSLDDGGATPHINMSFGGDDTKASTGFGFG
4) TGGKLDLGASGDGKNDSLNPWGGTGKNKQNTSGLDFSFGSAGIDDKPANTTAAKEPEDPWPSATAGKGKKKKKDSIGFGSTPAETEEKVPETEDWNEFSGSTSKKNKKKTTSAWGAIDEPSNDGVDFFADLGKNDEAAEPEPAPEPPVEEQPAEETPAPTKKDKKKKKKKAGAVEPEPEPEPEPEPALEPVKEESPVEEKPGENREDFGGATTTSKKGKKKKKDDIVDGLVPEPQSELPKEEKPVEVVDESWANVPALSSKEKKKKKKSAAAAETVTGVKPEPEPVVEAPLEEKQVGGGFWDSLAIPSSTKRDKKKKNEVVTAPVIPEPEPKPAVVEPEPVEEEGPIEPTGWGFGLPNSNKKKKKKSAATDPPPPPPPPPEPEPEPIVEPVEEIKEEQPAETFWGFTTKKDKKKKKNELEPAPVEPEKPKDLFDNDDSWCNEFDQDKELKSAGADLLDDGPKVDDSTWMGLTSSKNKKKKGKTTADTVTPGAFDFGDDPALEATGGADEVSWFGLGK
1187
765
1
242
2049
1167
234
758










Molecular Recognition Features






MoRF SequenceStartStop




1) AAEENIASKALEKDPFALDDIID
2) DFFADLGKNDE
3) DLADI
4) EPEVVEVRELPSE
5) EVLDV
6) FWDSL
7) FWGFTTKKDKKKKKNELE
8) GKKKKKKKGK
9) GTWDIWGTITN
10) IEPTGWGFGLPNSNKKKKKKSAA
11) IKMAEEEEEAVEA
12) KASVAERIKQLEQSRKTE
13) KEKKKKKKS
14) KGKKKKKDSIGF
15) KKDSKKEKDAKKEAKKKKVDVAK
16) KKKKKK
17) KKSSKKEP
18) KLSKKEKKKKAA
19) KRPEGLFGFLSLRKP
20) KRTSWFKKLTSGF
21) LLDLVDEE
22) MNISVDLKDTSRFRTTAKKKKAAAKKPTPANDSWADENS
23) PKKGAKKERARIDRTAGAASWALW
24) VEEQPAEETPAPTKKDKKKKKKKAGAVEPEPE
25) VEPVEEI
26) VLEPVEDLS
27) WVKSQI
909
367
1405
1437
1375
541
644
94
1061
588
1418
1284
502
308
1222
180
1510
795
1740
2040
1194
1
1476
389
629
1333
1943
931
377
1409
1449
1379
545
661
103
1071
610
1430
1301
510
319
1244
185
1517
806
1754
2052
1201
39
1499
420
635
1341
1948