<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25886

Description Neurofilament heavy polypeptide
SequenceMNISVDLKDTSRFRTTAKKKKAAAKKPTPANDSWADENSKEGSGAGKEENQGDGANGGEGGGDPGGAGGSGGGDDPGGNEDKGGGEGDGDQSSGKKKKKKKGKKDDEEEEKKKREEEEEKKRLEEEEKKRLEEEEEKKRLEEEEKKRLEEENKAKAGADISWADDTNPEDWGFPGATTSKKKKKKNKGATELSPADPPPTTFQDVSLDDGGATPHINMSFGGDDTKASTGFGFGVWGTDWATGGKLDLGASGDGKNDSLNPWGGTGKNKQNTSGLDFSFGSAGIDDKPANTTAAKEPEDPWPSATAGKGKKKKKDSIGFGSTPAETEEKVPETEDWNEFSGSTSKKNKKKTTSAWGAIDEPSNDGVDFFADLGKNDEAAEPEPAPEPPVEEQPAEETPAPTKKDKKKKKKKAGAVEPEPEPEPEPEPALEPVKEESPVEEKPGENREDFGGATTTSKKGKKKKKDDIVDGLVPEPQSELPKEEKPVEVVDESWANVPALSSKEKKKKKKSAAAAETVTGVKPEPEPVVEAPLEEKQVGGGFWDSLAIPSSTKRDKKKKNEVVTAPVIPEPEPKPAVVEPEPVEEEGPIEPTGWGFGLPNSNKKKKKKSAATDPPPPPPPPPEPEPEPIVEPVEEIKEEQPAETFWGFTTKKDKKKKKNELEPAPVEPEKPKDLFDNDDSWCNEFDQDKELKSAGADLLDDGPKVDDSTWMGLTSSKNKKKKGKTTADTVTPGAFDFGDDPALEATGGADEVSWFGLGKKKSSKTDDPFEIPEFVDEVVEDTVPKEEEKKPVKETKLSKKEKKKKAAAAADPAPEVPAAEELPKVDFFEDTKEEPDLLASPPVDGFDSWGTRVTTSKKKDKKKNGAAAVLPNPEPELAPVVEPVEATDVGFGWGTGGTTAKSKKGRKGSAAEENIASKALEKDPFALDDIIDQPATDTKKKKKKGQKSTIEVVPNADPEPEPEPEPEPVLEPEPEPEPEPEPEPEPEPAQPSSWSLWGSSKPTKEKKSKSSKAATETIEETDKAAKGKKGKKATEEVIDVLPQDEGVGSGELVPVPKVADEGTWDIWGTITNSKKKGKKGASELPPPAPTPPEFPPEHGGDDITNTWDDITAPWPSSMKKGSLSRTTTSTSKASHVEESKLSKTKGKGLEVVDVSENPILETPIEDVSASNAAKGYWSSFGLASGGKAVDGADDLLDLVDEEEPKPASKPTSKADKASAKSSKKDSKKEKDAKKEAKKKKVDVAKEEEKEDEGWLDAASAPTADKATKQPTSAAATTSAPKAPGKASVAERIKQLEQSRKTEKEDTKAKESSKSKEKPKPEPPAPAEPVPEPEVLEPVEDLSTKPAKPSKKDAAASKTKSTSKTKSKSKSKADKGEVLDVVEPPVAAKEPTPRDSVPGSFPGAFDDLADIDEPEAPEPIKMAEEEEEAVEAPPPPPPEPEVVEVRELPSEPDAASLQRPSTAKADGDGADTMPASTPKKGAKKERARIDRTAGAASWALWGAAGASGPAPKKSSKKEPKSKDTGEPPVIKKDKERPSGLSRSKSSATKREKVSSLGAEVEKSSGSDKDRRPSRPSKHSRGMSFPFMLSGPPPTRSKSTKRASASKPTSRRHSIEIDDSGLLTPRESPDIPEKAAKTMGVESSKRVKRSSSHKKRSGPRDPYALDDDIDMLSPDDGLVSPPGRSLRDQEHRRKSRKESKKHNSDPALSPPGPEMPMGRDDFGINHPSPREPAPLRRANTSPKRPEGLFGFLSLRKPAPRAPEVRERPKSRSRHESSRRDTDREKDDSKRRKRSVRPDTDGEGFTTDAMRTGNNSPTEEAEARRAKRKAERARLREERDEKAREIEREGRRYKRHAREMEDVLHESKRDKKADRRSRSERPPKDPLSPTEGRRHRSHRTDDEGGKPRRRKSSPDNHRPRREKSSRHDHAVPYPVMVNGGKDKTSSWVKSQISDPPEAPPIVATVVDMPNPAREPQNASLSSDEEARRAIHRRSRRKSRAVDAMDVDVDRRPRRRESRREGRDPVRSNESSGDMDNRYGGMNPKRTSWFKKLTSGF
Length2052
PositionTail
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Microsporum.
Aromaticity0.04
Grand average of hydropathy-1.290
Instability index61.85
Isoelectric point6.08
Molecular weight222832.07
Publications
PubMed=22951933

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25886
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     489.54|      48|      48|     518|     565|       2
---------------------------------------------------------------------------
  307-  343 (35.67/ 6.36)	GKGKKKKKDS...................igfGS...T...........P..................AE..TE...E...K....VPE......TEDWNEFS...GS.T
  344-  400 (41.95/ 9.37)	SKKNKKKTTS...AWG.....AidePsnD...GV...DffadlgkndeaAEPE..P.AP.......E.PP..VE...E...Q....PAE.............E..TPA.P
  401-  456 (52.24/14.30)	TKKDKKKKKKkagAVE.....P...E..P...EP...E...........PEPE..P.AL..epvkeE.SP..VE...E...K....P.GenredfGG.....A..TTT.S
  457-  500 (35.14/ 6.10)	KKGKKKKKDD...IV................dGL...V...........PEPQ..S..........E.LP..KE...E...K..pvEVV......DESWAN....VPAlS
  501-  550 (73.84/24.67)	SKEKKKKKKS...AAA.....A...EtvT...GV...K...........PEPE..P.VV.......E.AP..LE...E...K....QVG......GGFWDSLA..IPS.S
  551-  600 (56.21/16.21)	TKRDKKKKNE...VVT.....A...P..V...IP...E...........PEPK..PaVV.......EpEP..VE...E...EgpiePTG......WGF....G..LPN.S
  601-  648 (58.15/17.14)	NK..KKKKKS...AATdppppP...P..P...PP...E...........PEPE..P.IV.......E..P..VEeikE...E....QPA......ETFWG.......F.T
  797-  855 (39.11/ 8.01)	SKKEKKKKAA...AAA.....D...P.aP...EV...............PAAEelP.KVdffedtkE.EPdlLA...S...P....PV.......DGF.DSWGtrVTT.S
  856-  900 (51.22/13.81)	KKKD.KKKNG....AA.....A............vlpN...........PEPElaP.VV.......E..P..VE...A...T....DVG......FG.WGTGG..TTA.K
 1308- 1360 (46.02/11.32)	KESSKSKEKP...KPE.....P...P..A...PA...E...........PVPE..P.EV.......L.EP..VE...DlstK....PAK......PSKKDAAAskTKS.T
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.63|      15|      15|      61|      75|       4
---------------------------------------------------------------------------
   72-   87 (21.17/ 7.02)	GGDDpGGNEDKGGGEG
  254-  268 (22.46/ 8.06)	GKND.SLNPWGGTGKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.99|      22|      24|    1412|    1433|       9
---------------------------------------------------------------------------
 1412- 1433 (29.13/ 6.83)	PEAPEPIKMAEEEEEAVEAPPP
 1471- 1492 (27.86/ 6.09)	MPASTPKKGAKKERARIDRTAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     132.27|      24|      27|    1816|    1839|      10
---------------------------------------------------------------------------
 1598- 1618 (25.30/ 8.97)	K...RASASKPTSRRHS..I..EIDDSG
 1619- 1640 (22.71/ 7.11)	LLTPRESPDIPEKAA....K..TMGVES
 1641- 1666 (23.06/ 7.36)	SKRVKRSSSHKKRSGPR..DpyALDDDI
 1816- 1839 (32.37/14.02)	EAEARRAKRKAERARLR..E..ERDEKA
 1979- 2004 (28.82/11.48)	DEEARRAIHRRSRRKSRavD..AMDVDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     570.18|     142|     304|     650|     794|      12
---------------------------------------------------------------------------
  148-  206 (54.24/11.03)	...................................LEEENKAkAGADIsWADDTNP.EDWGF..PG.ATTSKKKKKKNK.GATEL....................SP.A....DPP.....PTTFQDVS..............................................
  651-  794 (234.58/82.97)	KDKKKKKNELEPAPVEPEKPKDLfDNDDSWCNEFDQDKELKS.AGADL.LDDGPKV.DDSTW..MG.LTSSKNKKKKGKTTADTV....................TPGAfDFGDDPALEA.TGGADEVSWFGLGKKKSSKTDD...PFEIPEFVDE.VVEDTVPKEEEKKPVKET
  901- 1020 (125.17/37.19)	....SKKGRKGSAAEENIASKAL.EKD.....PF....................AL.DDIID..QP.ATDTKKKKKKGQKS..TIevvpnadpepepepepepvlEPEP.EPEPEPEPEPePEPAQPSSWSLWGSSKPTKEKK...S.KSSKAATE.TIEET.............
 1022- 1138 (156.19/47.10)	KAAKGKKGK...........K....ATEEVIDVLPQD...EG.VGSGE.LVPVPKVaDEGTWdiWGtIT...NSKKKGKKGASEL....................PPPA...PTPPEFPP.EHGGDDIT.........NTWDDitaPW..PSSMKKgSLSRTTTSTSKASHVEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.35|      29|     227|    1141|    1169|      14
---------------------------------------------------------------------------
 1141- 1169 (46.19/19.70)	SKTKGKGLEVVDVSENPIL...ETPIEDVSAS
 1370- 1398 (40.12/16.02)	KADKGEVLDVV...EPPVAakePTPRDSVPGS
 1544- 1564 (28.04/ 8.71)	SATKRE.....KVSS...L...GAEVEKSSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.24|      24|      51|    1845|    1874|      17
---------------------------------------------------------------------------
 1864- 1912 (23.26/18.02)	KRDKKADRRsRserppkdplsptegrrhrshrtddEGGKPRRRKSS...PDN
 2006- 2032 (38.97/14.01)	RRPRRRESR.R........................EGRDPVRSNESsgdMDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.36|      24|     222|    1688|    1717|      18
---------------------------------------------------------------------------
 1688- 1712 (42.94/16.29)	HRRKsRKES..KKHNSDPALSPP....GPEM
 1913- 1932 (39.60/10.80)	HRPR.REKS..SRH..DHAV..P....YPVM
 1940- 1964 (16.83/ 7.84)	......TSSwvKSQISDPPEAPPivatVVDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.98|      23|     227|    1566|    1592|      19
---------------------------------------------------------------------------
 1566- 1588 (42.41/16.13)	KDRRPSRPSKHSRGMSFPFMLSG
 1787- 1809 (37.56/12.88)	RRKRSVRPDTDGEGFTTDAMRTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.82|      16|      19|      31|      46|      21
---------------------------------------------------------------------------
   31-   46 (26.36/11.75)	NDSWADENSKEGSGAG
   47-   62 (26.56/11.90)	KEENQGDGANGGEGGG
  217-  232 (26.89/12.16)	NMSFGGDDTKASTGFG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25886 with Med2 domain of Kingdom Fungi
Unable to open file!