<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25881

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPVNAETNVRVFDELSTCYWRVYGVSSDGNDLGNEGIPVSQLFNKVEICTLALRDSGCLTCPSSDGTGLWVFSPDPEFSKLKSCSSSQGNNPDKIRVGQVHIQEIFSGIVSVAELSQKLQSEPSGSILSSTQTKERAGSSKLKLPKFLELTNATLYTSFISSIAWSISLHLAKNHQAIPLGKRTFFTVTDSDIPHGGKPNSMISTLDIETSQSGKVVISLRSEFQTGITQLSEQPGLNSTGDLRLHDDVWLAPTGTIARYIGIGGSEYAFETSTPYLTNKNAYGTRNDFLGESQNIWKLAVCSWIERSGIPIEISDSMRWIQVEIVASHQYQRLTKAASTRRIYWPAQLCFKRAPFSTSSTIQGAETLSRDSIGPLQYAHQWLSCSAPRDEALKRNPPSDVAHYPVQDPQSEIASPDDMDIPNIAESMARTIVYPDFQPAAVYPTPPGGALGFGQLSSDNHGGQYPLDISQASREGSDPNINERLNPNTRLLLEASSPGFGVGVGMYDTAGDDDLFEEIGDNFDDKEITEADFNFFDEPGLSDSNLDLDPGHVNHGFLIPDSDTADVKADLEMSEPPASTEPLEATKHQEMETPTLDSGLKDDLNQVYTEARSSPPVDEEDAERNTERPISPPLSPSGIKRILFSTTRENSNGVGNGTPSITMLSTEGDTGPGQLRSRYDAVSFQHELDSSDRKYGIDGRFWFLPGPNNVNQNAGSDTIKIPTINELPSSLCKVGQATYSYRGNHSMDSPDSERSSTANSSNSSISGDSYSQPELNMMRPVDPIDARLRRGDLEEIFSVSSSLQSPGFNVRKSYATQSDLEQDVLLAGLVHPSADWSLSGYFTAFEPTVRSALCSRDDKIHVAQLLVDQITQSSLVHKMEIISEQDENDTWLSFLDDIGTLGQSRRPNLKCYASISEGNQQMKDATSGAIISLRPPHIHIRRGSCSLDVLPTAIPFWETFGLGPLKGKKDIISYCLHPVSMQEGASAFLDRLGLTYLGANLGTCSHPGSTKGLIPWSLSQNKLDYSSIMRKLQHICENLGTALSNLTMNNKSIVVYIVNPFKIGAATVDICVAFLRLFHKYIEEADKRATRRLNELVLQIIPSDFITANDSLVIPTQNDYLRLALEVYSRCPPHEPVLDMFGCAPAFTLAAPIPKVIPFRLTVDEGSPMDTSQPYHVAYSVSYDQRWVTAAWTDSIGLRQLTLSYSLREDISRTCRSMSEVREDIWQTTVDMTGLSRGRWRVVIARDEPMDAEEVAAWVSLAAHHNQHQSGQVDLILLTVNTKPNLRMKIPPPPPQLNILYQSGNASTPVSTPKHSISSPDQFTTAQTPPNISSFAVNTPSSSSELAQPQTQPQSQVHPTQISVDPNTETLLVDKSDDAWALILSQRLNNSQSFTTYTPALANGYLICRYDPNSSQHSFEGSAKYIPGYGLIG
Length1435
PositionKinase
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Microsporum.
Aromaticity0.08
Grand average of hydropathy-0.388
Instability index48.62
Isoelectric point4.97
Molecular weight157586.11
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     618.02|     183|     941|     285|     519|       1
---------------------------------------------------------------------------
  285-  519 (274.94/227.64)	YGTRNDFLGESQNIWKLAvcswIERSGiPIEISDSMRWiqVEIVASH.QYQRL..........TKAASTRRI.YWPAQLcfkrapfstssTIqgaetLSRdsigplqyahqwlscsaprdealkrnppSDVAHYPVQDPQSEIASPDDMDI....PNIAESMARTIVYPDFQPAAVYP....TPPGGALGFGQLSSDNHGGQYPLD.ISQASREGSDPNINERLNPNTRLlLEASSPGFGVG..VGMYDTAGDDDLFE
  747-  821 (63.89/15.86)	............................................................................................................................................HSMDSPDS.ER....SSTANSSNSSISGDSYS....QPelnmMRP...................VDpIDARLRRG...DLEEIFSVSSSL....QSPGFNVR..KS.YATQSD.....
 1228- 1422 (279.19/145.57)	WQTTVDMTGLSRGRWRVV....IARDE.PMDAEEVAAW..VSLAAHHnQHQSGqvdlilltvnTKPNLRMKIpPPPPQL...........NI.....LYQ............................SGNASTPVSTPKHSISSPDQFTTaqtpPNIS.SFA..VNTPSSSSELAQP...qTQPQSQVHPTQISVDPNTETLLVD....KSDDAWALILSQRLNNSQS..FTTYTPALANGylICRYDPNSSQHSFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.80|      51|     226|     664|     725|       2
---------------------------------------------------------------------------
  231-  284 (77.99/39.95)	TQLSEQpGLNSTGDLRLHDDV..WLAPTGTIARYIGIGGsEYAFeTSTPYLTNKNA
  664-  716 (89.81/69.83)	TMLSTE.GDTGPGQLRSRYDAvsFQHELDSSDRKYGIDG.RFWF.LPGPNNVNQNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.51|      79|     178|     949|    1041|       3
---------------------------------------------------------------------------
   14-  106 (131.82/72.05)	FDELSTC..YWRVYGVSS.DG.NDLGNEGI.PVS.QLFNKVEICTLALRDSGC.L.TC..P.SSDGTGLWVFSPDpefsKLKSCSssqgnnpdkI.RVGQvHIQE
  949- 1039 (101.68/102.02)	LDVLPTAipFWETFGLGPlKGkKDIISYCLhPVSmQEGASAFLDRLGLTYLGAnLgTCshPgSTKGLIPWSLSQN....KLDYSS.........ImRKLQ.HICE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.98|      17|      36|     532|     549|       9
---------------------------------------------------------------------------
  532-  549 (26.07/20.56)	EADFNfFDEPGLSDSNLD
  570-  586 (29.91/17.96)	KADLE.MSEPPASTEPLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25881 with Med13 domain of Kingdom Fungi
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