<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25878

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMVEMEETLDDLFGDPGGLELSLTAAVPAKALPARIDELRILGCCQKIAWSKMGAIAYIAPDGSKAFLRNLSCSPEDGKWSLSDGDPEHPIAEAQGGHTLVHLSWNEPGIDLAIVDSCGRISVIGMSIGLNVLIQSRPAALDPDDDGNQPVGLMWLSMNRSVHTFSHAGRANGRWAYVRYPRRPMGPIHPLHKLALLVVTRSGKLRLLYQNQESKWGDMVVELHNTGYTDDVLTHASMTPVDGGGIMIVTHSTSNELRLYRAQLKWEGAPVDPNHQRPNNSIAIPSIQLVHIEVEVPHVVPSPSTYVTGDPENITNNANGLFALTHLQIIACPVDAPGGQTAPMILAVFSCPIHNAHGRSHLQHPTVLARWEFRTVNQNLHRSFDSIVSKQACQPLLPSTELKRQEDIYFERHVISIDYMEAGNILTITTEDGNIAFYDAKSFTPLSGPNDVETVTSLPQSGFTFPAAISPVVQGVHISFSPSGCIAASLDEKSQVQIRIMEHSFGTEEDGLFNDGKFMSALAALTMAYCRACSSDSNNDDILMIVIQQLNPDSHKKFINEVYRALSMNVDFTVDQDKLMNNPYILKCFSMQAALGFKNQLERRSLPAAIPWLTLQLRQISILLTYYFHLNKANTEVECHDPEVLSITLGNVKWALDLAKYLVDDLFEISDNFNSQTGSQESGSSSGKPYESLSLILIISSIPRSFLKYICRGLRGLTNGFRNATNLSNESYQMYSQIVTVIAESALKVDVYEKLLAYVDNDIKHAYQNAGFTNADRAAPERDLLINGSIPPVLQPAVTSILTKTMPMIRNEANPMYLFLQDYSWLGVGDDKRSDIFRQKYELDILRKVLIPLDESRGAARPSRRCVRCCGVSEDVPPKSVAAVRMLMRTVVLRACTCGGMWSMSNANSLRGTTLPGWRQAG
Length921
PositionTail
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Microsporum.
Aromaticity0.07
Grand average of hydropathy-0.140
Instability index48.94
Isoelectric point5.87
Molecular weight101720.98
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25878
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.57|      13|      91|     232|     244|       1
---------------------------------------------------------------------------
  232-  244 (25.75/15.77)	LTHASM..TPVDGGG
  323-  337 (21.82/12.22)	LTHLQIiaCPVDAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.57|      41|      85|     695|     735|       2
---------------------------------------------------------------------------
  659-  686 (30.64/13.83)	............KYLVDDLFE..ISDNFNSQTG.SQESGSSSG
  695-  735 (66.56/37.68)	ILIISSIPRSFLKYICRGLRG..LTNGFRNATNLSNESYQMYS
  744-  781 (38.77/19.23)	SALKVDVYEKLLAYVDNDIKHayQNAGFTNADRAAPER.....
  783-  823 (60.60/33.72)	LLINGSIPPVLQPAVTSILTK..TMPMIRNEANPMYLFLQDYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.60|      63|      92|     348|     422|       5
---------------------------------------------------------------------------
  348-  422 (91.00/100.34)	FScPIhnaHGRSHLQHPTVLARWEF......RTVNQNLHRSFdsivSKQACqpLLPSTELKRQEDIYFERHviSIDYMEAG
  442-  510 (105.60/74.08)	FT.PL...SGPNDVETVTSLPQSGFtfpaaiSPVVQGVHISF....SPSGC..IAASLDEKSQVQIRIMEH..SFGTEEDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.27|      16|     822|      67|      85|       7
---------------------------------------------------------------------------
   67-   85 (26.44/23.33)	LRNLSCspeDGKWSLSDGD
  892-  907 (33.82/20.29)	LRACTC...GGMWSMSNAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      26|      49|     195|     221|       8
---------------------------------------------------------------------------
  195-  221 (41.31/31.75)	LLVVTRSGKLRL.LYQNQeSKWGDMVVE
  245-  271 (42.45/27.75)	IMIVTHSTSNELrLYRAQ.LKWEGAPVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.77|      28|     822|      10|      44|       9
---------------------------------------------------------------------------
   11-   38 (48.75/46.09)	LFGDPGGLE.LSLTAAVPAK......ALPARIDEL
  578-  612 (42.02/18.17)	LMNNPYILKcFSMQAALGFKnqlerrSLPAAIPWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25878 with Med16 domain of Kingdom Fungi
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