Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MQPPYVRERLDSLVQIDEQLCSLLQTASQVVFTYGELKHGNHDLKPQFEQHTREFYTTLESSTNQLKQEIKLLDENVGTRLLPINVNKKALGQDDDKLKEQTELLKQLLDKPPSN |
Length | 115 |
Position | Head |
Organism | Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.790 |
Instability index | 31.70 |
Isoelectric point | 5.33 |
Molecular weight | 13303.88 |
Publications | PubMed=19525356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25865 No repeats found |
MoRF Sequence | Start | Stop |
1) FEQHTREFYTTL 2) QLKQEIKLLDENVGTRLLPINVNKKALGQDDDKLKEQTELLKQLLDKPPS 3) YVRERL | 48 65 5 | 59 114 10 |
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