<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25856

Description ZYRO0D05368p
SequenceMSSGGKDTLSLEERSRNVQDLLQVLMDINDINGGNSDIAEKMKVHAKNFEAALYAKSSSKKEYMDSMREKVNAMRNTRDTRKKAAASAVSMGAVNRAMLTQQQQQQQQRLQQAGMAANGGFVPNTLNMNSHMFLNQQAQVRQQAQQQLRNQQQQQQQAQQQQQQLHGQPQTPQLSAQHQQLINQMKVAIIPRELLQRIPNIPPGVNTWQQITELAQQKRLTAQDMQIAKEIYRLHQQLLYKSRLQQASVNNRMNLQQQEQLHQQRMAGVNGLQSQQSQGPTPQQLAQQHQGGLQQQQQQQQQQQQQQQQQQPTTLQQQQQQQQHAQQQRLQQQQQQQQAQQQQGRSVKSEGEFPNMLSQINQIFTPEEQRALLHEAMEACKNFQKTQFGNNMTDSNRQNFIRKYINHKAIKKIQNVRLAQMAASGATPQQHAAPNNQRHSVSLQSQPSAGVGTAGPAGGAPTGGRPSSSTIAGAPAGGSGGGGPPNNGTPNVHNSMPSQGALNAQYNQANLRNNAAAAAAQGGAPIQQPNRMAQPQARPSVLQAFAPTPQDVEVVKRISADAARTPLRLSDLTNTLSPQERDEIKRMLQINQQLFAQVSNYAPQVYVFTKSENFLKEVLQLRIFVKEILEKCAKEIYVVKLDTVEKLVIKYKKYWESMKIQLLRRQQLIQQQQQLQQQKQKLAVQQQAAGNTQAGLNISQQQQRVQGSLQQIQQQMQQKQRQQQQMQQQQQVQQQPVPKVPPTNSNIALAAQNAVTNMSNPSANGTPGVNAAGATNYQPPLSDASMGMSAGSAVGVEAPRTGLGLDFMGSPNLAKGSPPTGATTGMSPKRELAKAAATGNFTKARSNSLKPSPNASQSNMNTPVVVPPPTGSGSATPGVLNVGDGISPLNGKPLAVANHKTPSPLTVPSISQVQATASNTDNHPFEEEEDALRKMNIRKAEIISRFKHRQEVFGKSPLDMFLSTLADCIGVKDANVEAVMTIPPAVVDQVNGTGKKKLSKMAQKARDQDVVLVSIKDNNKLVMESKTNPKSQSYQVPSDALGSVFKDVYGTSDIMTMNFNDPFGISRSVSDGAVVGSSQINARKRKLEELEISPANSANSPSSSLMSDSKKVKIDSPEDMFVTRYGGDSDTKQLMNTGVPSTNVWDWNYWAKLEQP
Length1156
PositionTail
OrganismZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces.
Aromaticity0.04
Grand average of hydropathy-0.786
Instability index60.18
Isoelectric point9.86
Molecular weight127116.40
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25856
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.39|      15|      15|     142|     156|       2
---------------------------------------------------------------------------
  146-  162 (27.98/ 8.17)	QQLRNQQQQQQqaQQQQ
  328-  342 (30.30/ 9.59)	QRLQQQQQQQQ..AQQQ
  666-  679 (26.70/ 7.38)	QQLIQQQQQLQ..Q.QK
  710-  723 (25.41/ 6.59)	QQIQQQM.QQK..QRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.48|      35|      37|     754|     789|       3
---------------------------------------------------------------------------
  754-  780 (41.49/18.51)	.................AVTNMSNPSANG.TPGVNAAGATNY...QPP
  782-  819 (46.91/23.15)	SDASMGMS......agsAVG.VEAPR.TG.L.GLDFMGSPNLakgSPP
  820-  863 (42.07/16.35)	TGATTGMSpkrelakaaATGNFTKARSNSlKPSPNASQSNMN...TP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.20|      26|      26|     449|     474|       4
---------------------------------------------------------------------------
  418-  440 (29.75/12.05)	...LAQM.AASG.ATPQqHAAPNNQRHS
  441-  467 (43.60/21.47)	VSLQSQPsAGVGTAGPA.GGAPTGGRPS
  468-  491 (39.85/18.92)	SSTIAGApAG.GSGG...GGPPNNGTPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     268.48|      46|     180|     100|     145|       6
---------------------------------------------------------------------------
  100-  141 (72.46/25.57)	..............................TQ.................QQQQQQQRLQQ...............AGMA..........ANG.GFVPNTLNMNSHMF.LNQQ....AQVR
  142-  225 (40.05/10.77)	QQAQqqlrnqqqqqqqaqqqqqqlhgqpqtPQ.................LSAQHQQLINQ...............MKVAiiprellqriPN....IPPGVNTWQQITeLAQQkrltAQDM
  226-  262 (44.20/12.66)	QIAK......................eiyrLH.................QQLLYKSRLQQ...............AS..................VNNRMN.......LQQQ....EQLH
  316-  364 (30.78/ 6.53)	...............................Q.................QQQQQQQHAQQqrlqqqqqqqqaqqqQGRS..........VKSeGEFPNMLSQINQIF.............
  680-  705 (41.41/11.39)	QKLA..........................VQ..........................QQ...............A...............A.GNTQAGLN.......ISQQ....QQRV
  706-  752 (39.58/10.55)	Q...............................gslqqiqqqmqqkqrqqQQMQQQQQVQQ...............QPV...........PK....VPP...TNSNIA.LAAQ........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.87|      22|      24|     521|     542|       9
---------------------------------------------------------------------------
  499-  516 (20.46/ 6.16)	....QGALNAQYN....QANLRNNAA
  517-  538 (37.08/18.02)	AAAAQGGAPIQQP....NRMAQPQAR
  539-  564 (29.33/12.49)	PSVLQAFAPTPQDvevvKRISADAAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.69|      23|      24|     876|     899|      10
---------------------------------------------------------------------------
  876-  899 (36.31/28.27)	TPGVLNVgDGISPLNGKPLAVANH
  901-  923 (40.38/26.09)	TPSPLTV.PSISQVQATASNTDNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.33|      22|      30|     584|     607|      11
---------------------------------------------------------------------------
  584-  607 (33.20/30.84)	IKRMLQInqQLFAQ..VSNYAPQVYV
  615-  638 (31.13/20.87)	LKEVLQL..RIFVKeiLEKCAKEIYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25856 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KIQNVRLAQMAASGATPQQHAAPNNQRHSVSLQSQPSAGVGTAGPAGGAPTGGRPSSSTIAGAPAGGSGGGGPPNNGTPNVHNSMPSQGALNAQYNQANLRNNAAAAAAQGGAPIQQPNRMAQPQARPSVLQAFA
2) LQQIQQQMQQKQRQQQQMQQQQQVQQQPVPKVPPTNSNIALAAQNAVTNMSNPSANGTPGVNAAGATNYQPPLSDASMGMSAGSAVGVEAPRTGLGLDFMGSPNLAKGSPPTGATTGMSPKRELAKAAATGNFTKARSNSLKPSPNASQSNMNTPVVVPPPTGSGSATPGVLNVGDGISPLNGKPLAVANHKTPSPLTVPSISQVQATASNTDNHPFEEEEDALRK
3) SSSKKEYMDSMREKVNAMRNTRDTRKKAAASAVSMGAVNRAMLTQQQQQQQQRLQQAGMAANGGFVPNTLNMNSHMFLNQQAQVRQQAQQQLRNQQQQQQQAQQQQQQLHGQPQTPQLSAQH
4) SVNNRMNLQQQEQLHQQRMAGVNGLQSQQSQGPTPQQLAQQHQGGLQQQQQQQQQQQQQQQQQQPTTLQQQQQQQQHAQQQRLQQQQQQQQAQQQQGRSVKSEGEFPNMLSQINQIFTPEEQRALLHEAMEACKNFQKTQFGNNMTDSNRQNFIRKYINH
412
709
57
248
546
934
178
407










Molecular Recognition Features






MoRF SequenceStartStop




1) EDMFVTRY
2) FIRKYI
3) VWDWNYWAKLEQP
1118
400
1144
1125
405
1156