<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25855
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSENHDESSNDLNLVENGIQLALDPNLITLPLHGSVSSPLTNAPNSNAQTSENGNPDQMDVDSEPAQGNNNAGQSLINNPYGLFGQMPLEHLIPLVLQQKGPGFKFADLSEDALEEEIEKDKSGGDEDARPDLMDVDPSENQVEEVPPEAVEEDNQETTKDGEKEEETITQEQFVRMRREMVEHINIAMNESSLALEFLSLLLSSVRESVALSSMSPFLKKIVPVASLNSDRVSSEPKTVEDQLTMQVIDRGWKIRCLNESRTLLKENHSMLEEKLKNEHRYWKKISQYISNKDVIFKLRDKSTGLRSLGVKYGYEDSGSTYRLDRGVAILKTNPETNTLELVPITGENSPSPHNEKFIRIRIFTKIEFEDDYILSGESSVDNVFLNSDSSGKKDQEDIRSQIEKLKALIFEQELMYQLRRECAQLISYGVTIENEKKVVIELPNEKFEIELVSLDDASVVNHEQDAPKINDRRANLMLITVRMLLVVMFKKNLRQRLTSSTRNSHLNVDKDILLIRPLLGKMRHQNYKLLLRKILKTHVLDVVETSTFSETVVHPPRHENADDVNLDIHIAKLNQEISTFDRLLTTCKTQFDVKLVNEDKLSLTLESPNYCNLAVRVLYQNASKNVSFDTRFSEFKEVEEILHFIVNEYIKKT |
Length | 654 |
Position | Head |
Organism | Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.542 |
Instability index | 46.02 |
Isoelectric point | 4.99 |
Molecular weight | 74554.28 |
Publications | PubMed=19525356
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | activating transcription factor binding GO:0033613 IEA:EnsemblFungi
RNA polymerase II complex recruiting activity GO:0001139 IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP25855
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 158.45| 46| 240| 152| 197| 1
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152- 197 (74.39/46.30) EEDNQETTKDGEKEEETI.TQEQFVRMR...REMVEHINIAM...NESSLALE
355- 384 (23.80/10.26) ....................NEKFIRIRiftKIEFEDDYILS...GESSVDNV
393- 442 (60.26/36.23) KKDQEDIRSQIEKLKALIfEQELMYQLR...RECAQLISYGVtieNEKKVVIE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.68| 25| 31| 228| 254| 2
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228- 254 (39.17/28.72) LNSDR..VSSEPKTVEDQLTMQviDRGWK
258- 284 (39.50/22.99) LNESRtlLKENHSMLEEKLKNE..HRYWK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 98.93| 33| 304| 7| 44| 4
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7- 44 (50.64/49.20) ESSNDLNLVENGIQ.LALDPNLITLPLhgsvsSPLT..NAP
316- 351 (48.28/33.76) EDSGSTYRLDRGVAiLKTNPETNTLEL.....VPITgeNSP
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