<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25853
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTMASDSYALQLDEMIQLFQEYKSGSVTLDNITKLCQTLGLESFIDDIDAETSRLSTASKIIVIDIDFSKSIGRVKDVKLVLASNFDNFNYFNEPVVQANNDSNSNEGSNILLNSLTQYPDLHQFHHNLKFLYLLDTFSSINIDANNNGGPNNDGGGGEFSGELDLFKYFTELAQFLRQYFADQGAPLKVVTNLNNRFGIYIMTQLDRVLLAKITFEKSRDSQQRLYEYVYYEGNKEWINESPESFTSGVSMVMEISDKTNPTWFPKDYVPKELVLDEGDSNDKINDVSPNEFMNSLSMNASRGKFQVMNDFTTQLVPLRKFDISNDNSELIIEILRWIQWSRTVLYPIYKTLNAPEDEATKGDAGKEGTVTANGPQGRHGSVAAEHRKRRHSSKNKRSSMTEATMLKEEGLQQFNLQELMTDQDTDLNQGSEKASTGLLGVDKMQVDDQAIDDSDTTCQLVFSEDRVSLENVAQCTLYDDMAKWDSFIEAFKTYSI |
Length | 497 |
Position | Middle |
Organism | Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.514 |
Instability index | 35.59 |
Isoelectric point | 4.57 |
Molecular weight | 56279.99 |
Publications | PubMed=19525356
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP25853
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.13| 25| 44| 228| 252| 1
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228- 252 (48.22/28.41) EYVYYEGN.KEWINE.SPESFTSGVSM
273- 299 (36.90/20.25) ELVLDEGDsNDKINDvSPNEFMNSLSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 116.16| 37| 44| 97| 136| 2
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97- 136 (62.24/49.59) VQANNDSN.SNEGSNillNSLTQYPDLHQFHHNL.KFL..YLLD
143- 183 (53.93/35.15) IDANNNGGpNNDGGG...GEFSGELDLFKYFTELaQFLrqYFAD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.56| 14| 15| 7| 20| 3
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7- 20 (24.33/18.36) SYALQLDEMIQLFQ
24- 37 (24.23/18.24) SGSVTLDNITKLCQ
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