<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25849

Description ZYRO0C12034p
SequenceMTPSKYILTPPDDLHPYVPSKDSNRPKVYPDFDPWSHTKEEDEILLNYVSKGYYSTSKVNFESISARSSLQESLPKLSDQIAEQFSQVLHIREGEVNKIFSGRPDSNVSFFNDLCGPGFALPSRVTLTEHRRELWLQELSSPYASLHKLSKHIPHGLKRRQVLEQCYTKRIPLKRAVWLIKCCNSIEWKALVTKHQQKQGEKVDVSNQLLKEWTDNFVYITEKLIFEMTQHYNDPVQLKRWRGDVGYFLKLLGNCYTMDLLDRDIFHHWLVEFCAKIENFELLPLTLHILMIFWDGICQKVQESSLSQPLFLVSKTAEMLLNKYYTVSHSKSMIDDDKYIINDNKKNNKIRESILSTLRFLICNLFQDQSLEAFIFPNSSWDLYKPILYEMVGNFQASPERLRETKKKLELISYRNESLRFNSSLRDEATSTELGNQSNGGVIKMEVDITKLSLVDTKFAQMLDDNPVGFDWASYVDRNILSVGQIRQLCLWAIHPSKKSHYEASQLAAKVLLLKMNSTDGFQEYVIEDVIWSLVFQVAKLSEPHRQSLVDLGRLYALLNVLITYGILKVSTYVRKLISSGILYLSESNDKFIHCDLLINLKISPLMKSQYNMVLRNVMEYDASYFEKYNFDQLLRLSDELKQRIVTGEDLDSGIYPLSIKIMTAEWYLTKLCSEKLAPVDKAILVKNFRIFCVHLRAFHHYYKWIEFVVYHQLLVDIEALEALMDILLCYNKLFSQLVNDHILFIKTFIFIYTKILKGKDTGSYAVTSFMPFWKFFIKSFPFALKVDEELKSELSAVYEEEKAKMERLSNNRQEALQVYNCIRGSGIKGMNLNFPEVFSTSLRSLLSLKDSPDEQKKFRNFLLLLMASSSRDYNKFMSIFLKRKDFEVVNLRYLISCKLLTFDLVQNVLGASFVLSLLSKNDVSPNSYYKYYEDLYVKNNFAGILKSCLSNNLLQNYDTFLEILVGHGTLSKLSSTSIKTIVKLFEESPSNSSQILDDLLHYGIPKLESNDTAPNDNPSQLYRSLNFANLWIFQAFTNFQIELILNVEGDCHTCLHDFLFEVVEATDYNCLCAHIFDRIEDMSVIELIAQTFEEDFFNKFFSVEELDKNYMAVIVEVLTSLSQKVHKDSSNDLKISDANFNLLKHIMSSFCQMPENEMQGLEAQLDVFLKIFSIHQNILFHHIIIAIQSGNYEEATALINDMYTLFDKISFNLRLKLMLYEVLSSLKSYCIYVSTAVTENSEQKFEVPERLLSLPPFQISSFMKEEDDRELNEEVDLGVSTIDTRTTMEREKFHRWFIFNKKENQYWCELQNEPYHYINNFQSEAVTSFNNSCLNLSLFNATFRRQNPK
Length1350
PositionKinase
OrganismZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces.
Aromaticity0.12
Grand average of hydropathy-0.201
Instability index44.45
Isoelectric point5.96
Molecular weight157277.86
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.45|      30|      69|      52|      81|       1
---------------------------------------------------------------------------
   52-   81 (51.21/32.91)	GYYSTSKVNFESISARSSLQE......SLPKLSDQI
  118-  153 (47.24/29.78)	GFALPSRVTLTEHRRELWLQElsspyaSLHKLSKHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     813.39|     229|     275|     828|    1062|       2
---------------------------------------------------------------------------
  656-  802 (163.66/86.87)	...................................................................................................YPLSIKIMTAEWYLTKLCSEKLAPVD.....K....AILVK.NFR.IF......CV..HLRAFHHYYKWIEFVVYHQLLVDIEAlEALMDILlcynKLFSQLVNDHILFIKTFIFIYTKILKGKDTGS.......YAVTSF....MPFWK......FfiKSFP.FALKVDEELKSELSAVYEEE...
  828- 1062 (358.78/215.96)	IKGMNLNFPEVFSTSLRSLLSL....................KDSPDEQK.KFRNFLLL..LMASSSRDYNKFMSIFlkRKDFEVVnLR.YLISCKLLTFDLVQNVLGASFVLSLLSKNDVSPNSYYKYYE....DLYVKNNFAGILKS....CL..SNNLLQNYDTFLEILVGHGTLSKLSS.TSIKTIV....KLFEESPSNSSQILDDLLHYGIPKLESNDTAPNDnpsQLYRSLNF....ANLWI......F..QAFTNFQIELILNVEGDCHTCLHDFLFE
 1086- 1341 (290.95/161.60)	IELIAQTFEEDFFNKFFSVEELdknymavivevltslsqkvhKDSSNDLKiSDANFNLLkhIMSSFCQMPENEMQGL..EAQLDVF.LKiFSIHQNILFHHIIIAIQSGNY.....EEATALINDMYTLFDkisfNLRLKLMLYEVLSSlksyCIyvSTAVTENSEQKFE..VPERLLS.LPP.FQISSFM....K..EEDDRE....LNEEVDLGVSTIDTRTTMERE...KFHRWFIFnkkeNQYWCelqnepY..HYINNFQSEAVTSFN...NSCLNLSLFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.39|      15|      64|     297|     311|       4
---------------------------------------------------------------------------
  297-  311 (27.86/15.12)	ICQKVQESSLSQPLF
  362-  376 (26.52/14.05)	ICNLFQDQSLEAFIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.54|      14|      62|     165|     178|       5
---------------------------------------------------------------------------
  165-  178 (28.50/16.35)	QCYTKRIPLKRAV...W
  230-  241 (24.74/13.29)	QHYNDPVQLKR.....W
  254-  269 (21.30/10.48)	NCYTMDL.LDRDIfhhW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25849 with Med12 domain of Kingdom Fungi
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