<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25845

Description ZYRO0A04268p
SequenceMASKSPEIIPQSPPQNGRLHENKLTQCFDDIMRVAVEMMLHQQLKTVQLDSSVVNGFSHNQQRMLSEKIHIFHAILDDMETTLGKSKDYVEAIYELGREKELQKEREREELRRRQEEEERKSKEQEELRRHQEMELKAQQEKEQQQQEQQEQQKQQKQDNDVEPDLKMKFSMDTPSGLLADFPGASGDMNETGAIPKNSDDKPVSPRQYSTKIKQEQGLPQGDLGDLGGMDISMFPNMDTGFDMGSMGGEPDPNKQGGSNDPTAGLPESENANDVAGTLGDPGNNGVVDNSDDYLTLNDFNDLNIDWSATGDPGDLDLNGFNI
Length323
PositionTail
OrganismZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Zygosaccharomyces.
Aromaticity0.04
Grand average of hydropathy-1.092
Instability index57.16
Isoelectric point4.48
Molecular weight36311.50
Publications
PubMed=19525356

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
cytosol	GO:0005829	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.16|      16|      16|     103|     118|       1
---------------------------------------------------------------------------
  103-  118 (27.18/13.78)	QKEREREELRRRQEEE
  120-  135 (27.54/14.04)	RKSKEQEELRRHQEME
  137-  152 (23.44/11.04)	KAQQEKEQQQQEQQEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.40|      67|      90|     163|     232|       2
---------------------------------------------------------------------------
  163-  232 (110.72/73.06)	EPDL.KMKFSMDTPSGL.....LADFPGASGDMNETGAIpKNSDDKPVSPRQYSTKIK.QEQGLPqGDLgDLGGMDI
  250-  323 (108.69/59.64)	EPDPnKQGGSNDPTAGLpesenANDVAGTLGDPGNNGVV.DNSDDYLTLNDFNDLNIDwSATGDP.GDL.DLNGFNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25845 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YELGREKELQKEREREELRRRQEEEERKSKEQEELRRHQEMELKAQQEKEQQQQEQQEQQKQQKQDNDVEPDLKMKFSMDTPSGLLADFPGASGDMNETGAIPKNSDDKPVSPRQYSTKIKQEQGLPQGDLGDLGGMDISMFPNMDTGFDMGSMGGEPDPNKQGGSNDPTAGLPESENANDVAGTLGDPGNNGVVDNSDDYL
94
295










Molecular Recognition Features






MoRF SequenceStartStop




1) LNDFNDLNIDW
297
307