<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25841

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTEVQGLTMLQVNGGANAEKNSQLANGSSKMVSQKRGKENSESVAVTKAPELPHVEVNQLPLALLIRNLTVFAVKELVQFLKTSVHEGQDSSAKKTTFLQLVVFLRNQFLKIYVLVKWCRTIKNNNFSTMIDLLNWFRNSNMAVNNCIWALKSSQAGMTNAKLPNPDLITALEVLSLGRPNLPTHNFRLSGEDTNSNPETGAAAIPAKLILKKLKDMNIIMSVKVSLMEVPEQFSHYSVRDGRLSIRVENEFEIQLSTTNQRSPLFFVDLRLLFNEFLPLNKYKLEKVINELLYKSPRPLFSLYKLLHNYVLSTQMYMLHAELLDLESNGKYSGGNLLHHYDPRKNRIGLKYWLHSRLSGKCNATIGIERQTGNIILRWDIEGGFDRQIDVPVRYTNVLNNLGVILDEIMFNHSQMIKTELLSTGVLQEDEETSDALLFNVPTTPASVMPIQLKINPTSGVFYVRNPSGLLTYYINQINATSTTEDFIKILSRLKLDKTILVLRNMFEKVGWVCNNVIQLGGPVSKDASRAQKKILSRDIFIRLDNWPANWYLILSVVSSNTACVIEKRIGKITASKGSWELKYLDTENLMILKLESMTYQKIIYLKKTCLHKIIDHMIIDSLNELHMRNKICAGDNLAALPDYMLQDNKTHHLSIIGIELESFLGGSNALSHILEKTMFLRIDYHESTIKLFGKFKHDSKVIGYQYNDMLIQFTGKGALSFFMSEEFTDLNNIVQYFQVFKQKLMQIVILTDVIERLHEFYSENFSIVALKPNEIAFKYLKNSKDAHDCMTNIVTSDHSVENLKINLSPSNPQHIVQPFIEAGKQDYHFIFNYLRFTSGFFGVLESILTDPPTKDHAQNQGQNQNGYTTVSLQLHNLSEYELIYYNPETNTKITLMIELRNVFLNGTKKLRYFVHFSEDEHISTKSPAYPLVHQVRNTIFMVDTASLSGGPAGSPKKPKYPSAVRLTDGVCCDAVDIESIIRSINDILKIDCM
Length995
PositionTail
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.165
Instability index38.54
Isoelectric point8.60
Molecular weight113263.49
Publications
PubMed=19525356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.56|      23|      25|     251|     275|       1
---------------------------------------------------------------------------
  234-  247 (17.94/ 6.32)	.....QFSHYSVR...........DGRLSI
  251-  275 (35.74/27.93)	NEFeiQLSTTNQR.....SPLFFVDLRLLF
  276-  302 (31.88/18.27)	NEF...LPLNKYKlekviNELLYKSPRPLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.81|      21|      32|     307|     332|       3
---------------------------------------------------------------------------
  307-  332 (33.25/30.17)	LLHNYVLSTQ....MYMLHAELldlesNGK
  338-  362 (36.56/21.57)	LLHHYDPRKNriglKYWLHSRL.....SGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.57|      39|      42|     453|     494|       4
---------------------------------------------------------------------------
  454-  494 (61.80/42.21)	LKINPTsgVFYVRNPSGLLTYYIN...QINAT...STTEDFIKILSR
  495-  539 (56.77/28.77)	LKLDKT..ILVLRNMFEKVGWVCNnviQLGGPvskDASRAQKKILSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.91|      14|      15|     108|     121|       5
---------------------------------------------------------------------------
  108-  121 (26.94/16.71)	NQFLKIYVLVKWCR
  126-  139 (26.97/16.74)	NNFSTMIDLLNWFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.35|      16|      43|     774|     789|       6
---------------------------------------------------------------------------
  774-  789 (28.25/17.02)	PNEIAFKYLKNSK.DAH
  814-  830 (26.10/15.21)	PQHIVQPFIEAGKqDYH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.09|      23|      43|     644|     666|       7
---------------------------------------------------------------------------
  644-  666 (40.15/25.23)	DYM.....LQDNKTHHLSIIGIELESFL
  685-  712 (36.94/22.64)	DYHestikLFGKFKHDSKVIGYQYNDML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.94|      17|      25|     397|     413|       8
---------------------------------------------------------------------------
  397-  413 (28.88/18.93)	TNVLNNLGVILDEIMFN
  425-  441 (28.05/18.17)	TGVLQEDEETSDALLFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.18|      12|      37|     721|     736|       9
---------------------------------------------------------------------------
  721-  736 (16.94/18.72)	LSFFMSEEFTdlnnIV
  759-  770 (23.24/12.97)	LHEFYSENFS....IV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25841 with Med14 domain of Kingdom Fungi
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