<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25838
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDENQDPIYSLALNCSRRRLPSNLFVNFYNELVNEKYGSMINSGEETDADIKQTNVCEKISSSLLRLLDAEKHFLIVDYVVEVLFINYNKELVKELLPQLYSIKDSSQLVLFLSKASAFFLRLTDKLVIDQICGDLGNVIVPSILSSSFNTQGEELIVAIAKFLRNVLSLSSNPIAISDPKVGDRVRELLNCLSKINRLLYKKVAGDFDSLLRLGGSAPPTAREERHGVSSPSIISPRYLESPINVTKQPQSLIPSSVNHQTVKLARYCKNLWLNSRIMGWRTNDVAFVTKYSKIEAEIMKKTSPSQLNVEAAMKDLIETAFTSFAQFVSNKQYHQANSAFNLLERQWNIFITKQLPLHIMENASDMPHIVINALENIDHKVVKALKSYASDKDDAKNRGEDLFDDLPNKNTDIRHDFLKSLIMIGLQPAAVLNDFLREDQVVDTKSLPTNDTVVIKNAQGVKETVDNFSQFIKDTIEDLDAESMFEATDGSLGNADNGIMQILRKFETLAATKQKDLANVFYDLFRESVSSFDCKTFSKTCCLMCFNMSHSLTTMFAFVNPQKFLAVAIEFVDQIWESSVRKASAGLNDESDFEPNTEFVCFTYALIFIVQVVGTYNVSLIEALSTSSSDPQSSFIVNYITKLGDIAPALKLNSTLDSSEVLKSWVRDLFINGSISDSLMKSANVKDLAVLIPFIFKESLSAVESGSIRDISALVGGFEYFLQPFLIVGLIGIVFWTEQYLTTLRSKDLAKDLLESIFDMLNSVLNPSTLNDESRPLHTLILRLNTVQLLKATRAFQTQTQSSYGTYSSDSEGSTKVDSLISHLEQVARSSILYNVDSSVINSEIGYQRKDINYTPFAITADNSINSILTNQVNSFWNLHSSTYYNIDYLFALIDIITPQRFLEDMLVVLQHKTTDAALPNSRTKGSDGENLFYLDYFFYFLVSHDVMKAENKTDILQYMSSTAESDLIFRKPAHEFQPSAKVEQPSDEDFDMLFGEDTSIPGNESEANINEIKADEISPINPEFLRCSFAAVLHCSLLANKAALESGHTSEVAVDQLTQLHDKYIEILKSSTV |
Length | 1075 |
Position | Tail |
Organism | Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Lachancea.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.100 |
Instability index | 42.21 |
Isoelectric point | 4.97 |
Molecular weight | 120617.58 |
Publications | PubMed=19525356
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25838
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 981.39| 225| 409| 338| 562| 1
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174- 331 (159.09/89.71) ...................PIAI....SD..PKVgdRVRELLNCLSKINRLLyKK...........VAGDFDSLLRLG....GSAPPTAREERH..GvsspsiisprYLESPIN.VT.KQPQSLIPS...SV.NHQTVKlaryCKNLWLNSRIMGWRTNDV.AFVTKYSK........IEAEIMKKTSP.SQL.NVEAAM....................KDLIETAF.TSFAQFVSN.................................................
338- 562 (369.10/218.22) NSAFNLLERQWNIFITKQLPLHIMENASDM.PHI..VINALENIDHKVVKAL.KS...........YASDKDDAKNRGEDLFDDLPNKNTDIRH..D..........FLKSLIM.IG.LQPAAVLND...FLREDQVVD....TKSLPTNDTVVIKNAQGVKETVDNFSQFIKDTIEDLDAESMFEATD.GSLGNADNGIMQILRKFETLAA.....TKQKDLANVFY.DLFRESVSSFDC.KTFSKTCCL..................MCFNMSHSLTTMFAFVNP
569- 745 (188.53/107.72) ..AIEFVDQIWESSVRKA.SAG.LNDESDFePNT..EFVCFTYALIFIVQVV.GT...........YNVS..........LIEALSTSSSDPQS..S..........FIVNYITkLGdIAPALKLNS...TLDSSEVL.......................KSWVRDL..FINGSISD....SLMKS........AN......................VKDLAVLIP.FIFKESLSAVES.GSIRDISALvggfeyflqpflivgligIVFWTEQYLTTL......
749- 974 (264.66/154.31) DLAKDLLESIFDM.LNSVLNPSTLNDESRP.LHT..LILRLNTV..QLLKAT.RAfqtqtqssygtYSSDSEGS.TKVDSL..........ISHleQ..........VARSSIL.YN.VD.SSVINSeigYQRKD.INY....TPFAITADN.SI.NSI.LTNQVNSFWNLHSSTYYNID..YLFALIDiITPQRFLEDMLVVLQHKTTDAAlpnsrTKGSDGENLFYlDYFFYFLVSHDVmKAENKTDIL..................Q..YMSSTAESDLIFRKP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.57| 12| 58| 24| 35| 2
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24- 35 (22.65/13.77) LFVNFYNELVNE
84- 95 (21.93/13.10) LFINYNKELVKE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.61| 16| 55| 59| 78| 4
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59- 78 (20.28/24.20) KISSSLLRLLDAekhfLIVD
115- 130 (27.33/17.94) KASAFFLRLTDK....LVID
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