<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25834

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEYKETPYRLEDLLTSFYRVENINKINYVQYIPSKPDAQWSIQAELALRKHNPKILVSLFSRELWCFSINEEELPKLNLDLLGNPPSPEKIGYFTPNISKPNLPTAYAVFLKALRRKIHINICLKSHQRIIPFGNSCLYNTNEKTNKVIHFEPQLFENGDLCISICTKDVNLRSFNTKTINENFMKSNAIYLAPSGIRAYLVSSDIKKCVSPPPKSASVLLITLLVSHGIDLTKKKDITWVKVTPNLDHLNGYTPSISGYLDPPKATKTAIWPLELCFSQLADSLVSTQTPPSPRVPDLQGTFDIIDDFIQLKLTSAFKSPGNTCTGASIGTATGNEALSTGGTYGEQYQAFHKRSQSGSMSAAGPVGYQLGARQSPSINAANLTPANNKPASHPPDAYINGFLTTPNINESVDANNDDIMLGVSPQKLRSELWSEKKDSDVGFGLKLNTPVENTEISTASEKDDADLDAELFGDDNADDEVPGNSNLKGDENKQVEQGVKDITDEMFDMADESDSPKDKSEVAKQPAVLDLRRSPFKRKYLDIPLEEMTLPSTPLYTDPGAPLPVETPKDRKKSVFAPLNFNPIIESNVDNKYKNGGKFSFDGGKVEESLKFDVSTANVSSSEDDETGSSADEFDDMFTGGDNFKSTDVNAPTTAFAAESQTGNVPEFVQQDTPPLPIFDNSVNNEKAIRDNSLEMWKFSRDQSSQDFGSPKTHSSSSSARPSQFQIAGNGSNDLLKPNNTNPLLEQTSKSYLPINDNNVDSTNGVDKEIGDSLSPESMPTPESSNSLPFLLRHMPLFSIPDAFFLNNPSLAANDDIPSLLDLLCEQIVFDQGKMGDLKCRTATYNNFEACSDGVVKTTIDDIFSKFQRLHGGELIEEISPIRQPAVYVKKNDEVIKIKSDSEPFSQYLHLKPYKGIKSFKGLFLTTILKNDCLEFLSTMSQIYSSHELGFCELVKLTSADTPGLIYLVNLEESTLSLLSAQIVSYCSTNTLNTMSVPLVVFLPIMSSNLSEVVAMTLKFQFIKNEILSKLPSVKLCLKLIPLDFVKDPLTSIEEYYDFCVGIYNTLPPKSDKFTSIADEVPKKIEFRTIQKTNGQTSHFDVYIHLAYARSVDRNWICAAWSNSNGSENGVKTWYIGNSKNAFEDACNRMWRITLKFASNKYGRVCLVLSRFDSVLPDDELMHWRRLSSTSRNLHLAVVCVGDNTKVSLYDEDRIYPSFKPIFRDGRLSQKIDTSNLDNYEIVDIGSEIHGIVFRSPLHLANSQHRCAINTGALVRFKAADCDEILDKMEVNLLNCPHSDSTKLLKIILQEFRNLASLNPWFGISKSKDAFVPWHVLAVKKMLRTMVHLKVKDNP
Length1356
PositionKinase
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index41.12
Isoelectric point5.39
Molecular weight151035.13
Publications
PubMed=19525356

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25834
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     466.46|     116|     160|     370|     529|       1
---------------------------------------------------------------------------
   68-  160 (133.99/66.13)	........SINEEELP.KLNLDLLGNPPSPEKIGYF.TP.NISKPNLPTAYAVFLKALRRKIHINICLKSHQ.RIIPF.G...NSCLYNTN.........EKTNkvIHFEPQLF..ENGD...............
  376-  493 (192.35/167.64)	SP......SINAANLT.PANNKPASHPPDAYINGFLTTP.NINESVDANNDDIMLGVSPQKLRSELWSEKKD.SDVGF.GLKLNTPVENTEISTA....SEKDD..ADLDAELFgdDNADDEVPGNSNLKG.DEN
  535-  651 (140.12/64.94)	SPfkrkylDIPLEEMTlPST..PLYTDPGAPLP..VETPkDRKKSVFAP.....LNFNP.IIESNVDNKYKNgGKFSFdGGKVEESLK.FDVSTAnvssSEDDE..TGSSADEF.....DDMFTGGDNFKStDVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.88|      47|     160|     775|     830|       2
---------------------------------------------------------------------------
  775-  830 (69.93/70.82)	LSpeSMPTPESSNSLPFL.LRHMPLFSIPDAFFLNNpsLAanddiPSLLDLLCEQIV
  938-  985 (75.95/49.87)	LS..TMSQIYSSHELGFCeLVKLTSADTPGLIYLVN..LE.....ESTLSLLSAQIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.40|      22|     160|     669|     692|       5
---------------------------------------------------------------------------
  671-  692 (41.15/23.99)	QQDTPPLPIFDNSVNN....EKAIRD
  748-  773 (34.25/13.24)	QTSKSYLPINDNNVDStngvDKEIGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.79|      12|      16|    1126|    1137|       9
---------------------------------------------------------------------------
 1126- 1137 (22.99/14.02)	NGSENGV.KTWYI
 1142- 1154 (19.81/11.11)	NAFEDACnRMWRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25834 with Med13 domain of Kingdom Fungi
Unable to open file!