<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25829

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAGEEPQANGFRSDSTYKKPLAIDPNLIRPVPSFASPTADSDNDHKDDQSQPSTGVTQPLVNNPYETFGNMPLDQLIPLILQSRGPGTKFADLTEESLMEEIMKDAPLPQAQQDSDGDLDMDGSQLTNDPGQRTPEPQQIEGPAQADEDAVLSQEQFRQLKASTVQSLNLAVNESSLALEFVSLLLSSVRPSAANASMSPFLKKTVPPASLNAEKIPFQKPSSDEVLERSLIAKGWKQRSLEESRTLLKDSYLALEKSLKKEHSYWSKVSHNISKKDVVFKMKDRETGEKSLGIKYGYEDSGSTYTQERGIAVLRHNSKLDNLELVPADRQQANALGKENNEKFVRVRIFTKIEEEDDYILTGESHLDKLLIPNQVAGEQNDFRRQISRLKFFIFEKDLMYQLKRESENLISYGVSIENENKITIEFPTEKLELETMHVNDDVIMNHQQDAPKTNDRKATLVLIMLRMLLVVIYKKQLRKKLLCPQTSIGASAKSPKVHKVVGRLQDNEVLLLRPIIGKFKHESYVSLLKKIIKGFVLDVVEGSSVRKVENPSNTVTIKDEVVYDNHIAKLDKEIHLFDKILEMPRSDLLVETPKAGTILFLLQSSNYCNATTGVKYTNGAGETLFDTSFSNFKELEDFLHFIVSEYVSGGQENGVKYE
Length659
PositionHead
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.07
Grand average of hydropathy-0.520
Instability index47.50
Isoelectric point5.45
Molecular weight74140.15
Publications
PubMed=19525356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25829
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.65|      41|      45|     284|     327|       1
---------------------------------------------------------------------------
  284-  327 (58.65/45.96)	DRETGEkSLGiKYGYED..SGSTYT..QERGIAVLRHNSKLDNLeLVP
  329-  373 (61.01/35.23)	DRQQAN.ALG.KENNEKfvRVRIFTkiEEEDDYILTGESHLDKL.LIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.59|      29|      75|      30|      59|       2
---------------------------------------------------------------------------
   30-   59 (48.57/38.80)	PVPSfASPTADSDNDHKDDQ..SQPSTGVTQP
  107-  137 (50.02/34.28)	PLPQ.AQQDSDGDLDMDGSQltNDPGQRTPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      15|      15|     189|     203|       3
---------------------------------------------------------------------------
  189-  203 (27.18/18.32)	VRPSAANASMSPFLK
  206-  220 (27.69/18.80)	VPPASLNAEKIPFQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      21|      27|     227|     250|       5
---------------------------------------------------------------------------
  227-  250 (31.17/28.36)	LERSLIAKG..WKQRSLEESRtllKD
  255-  277 (32.43/20.90)	LEKSLKKEHsyWSKVSHNISK...KD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.34|      19|      19|      64|      82|       8
---------------------------------------------------------------------------
   64-   82 (33.86/24.76)	PYETFGNMPLDQLIPLILQ
   86-  104 (31.48/22.48)	PGTKFADLTEESLMEEIMK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25829 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAGEEPQANGFRSDSTYKKPLAIDPNLIRPVPSFASPTADSDNDHKDDQSQPSTGVTQPLVNNPYETFG
2) RGPGTKFADLTEESLMEEIMKDAPLPQAQQDSDGDLDMDGSQLTNDPGQRTPEPQQIEGPAQADEDAVLSQEQ
1
84
69
156










Molecular Recognition Features






MoRF SequenceStartStop




1) MAGEEPQANGFRSDSTYKKPLAIDPNLIRPVPSFAS
2) MEEIMKDAPLPQA
3) NPYET
4) QLIPLIL
1
99
63
75
36
111
67
81