Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAGEEPQANGFRSDSTYKKPLAIDPNLIRPVPSFASPTADSDNDHKDDQSQPSTGVTQPLVNNPYETFGNMPLDQLIPLILQSRGPGTKFADLTEESLMEEIMKDAPLPQAQQDSDGDLDMDGSQLTNDPGQRTPEPQQIEGPAQADEDAVLSQEQFRQLKASTVQSLNLAVNESSLALEFVSLLLSSVRPSAANASMSPFLKKTVPPASLNAEKIPFQKPSSDEVLERSLIAKGWKQRSLEESRTLLKDSYLALEKSLKKEHSYWSKVSHNISKKDVVFKMKDRETGEKSLGIKYGYEDSGSTYTQERGIAVLRHNSKLDNLELVPADRQQANALGKENNEKFVRVRIFTKIEEEDDYILTGESHLDKLLIPNQVAGEQNDFRRQISRLKFFIFEKDLMYQLKRESENLISYGVSIENENKITIEFPTEKLELETMHVNDDVIMNHQQDAPKTNDRKATLVLIMLRMLLVVIYKKQLRKKLLCPQTSIGASAKSPKVHKVVGRLQDNEVLLLRPIIGKFKHESYVSLLKKIIKGFVLDVVEGSSVRKVENPSNTVTIKDEVVYDNHIAKLDKEIHLFDKILEMPRSDLLVETPKAGTILFLLQSSNYCNATTGVKYTNGAGETLFDTSFSNFKELEDFLHFIVSEYVSGGQENGVKYE |
Length | 659 |
Position | Head |
Organism | Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.520 |
Instability index | 47.50 |
Isoelectric point | 5.45 |
Molecular weight | 74140.15 |
Publications | PubMed=19525356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25829 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 119.65| 41| 45| 284| 327| 1 --------------------------------------------------------------------------- 284- 327 (58.65/45.96) DRETGEkSLGiKYGYED..SGSTYT..QERGIAVLRHNSKLDNLeLVP 329- 373 (61.01/35.23) DRQQAN.ALG.KENNEKfvRVRIFTkiEEEDDYILTGESHLDKL.LIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 98.59| 29| 75| 30| 59| 2 --------------------------------------------------------------------------- 30- 59 (48.57/38.80) PVPSfASPTADSDNDHKDDQ..SQPSTGVTQP 107- 137 (50.02/34.28) PLPQ.AQQDSDGDLDMDGSQltNDPGQRTPEP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 54.88| 15| 15| 189| 203| 3 --------------------------------------------------------------------------- 189- 203 (27.18/18.32) VRPSAANASMSPFLK 206- 220 (27.69/18.80) VPPASLNAEKIPFQK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.60| 21| 27| 227| 250| 5 --------------------------------------------------------------------------- 227- 250 (31.17/28.36) LERSLIAKG..WKQRSLEESRtllKD 255- 277 (32.43/20.90) LEKSLKKEHsyWSKVSHNISK...KD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.34| 19| 19| 64| 82| 8 --------------------------------------------------------------------------- 64- 82 (33.86/24.76) PYETFGNMPLDQLIPLILQ 86- 104 (31.48/22.48) PGTKFADLTEESLMEEIMK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MAGEEPQANGFRSDSTYKKPLAIDPNLIRPVPSFAS 2) MEEIMKDAPLPQA 3) NPYET 4) QLIPLIL | 1 99 63 75 | 36 111 67 81 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab